{"id":114,"date":"2020-07-01T11:30:16","date_gmt":"2020-07-01T11:30:16","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=114"},"modified":"2020-07-01T13:21:01","modified_gmt":"2020-07-01T13:21:01","slug":"114","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=114","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa berberina induce la apoptosis en las c\u00e9lulas de c\u00e1ncer de mama (MCF-7) a trav\u00e9s de la v\u00eda dependiente de las mitocondrias\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-vSGPQz1vhwA\/XvyNfMKn7VI\/AAAAAAAAeA4\/3cBzlnVstEkjuUCyNLjUOQRWBheFihvLACLcBGAsYHQ\/s1600\/European_Journal_Pharmacology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-vSGPQz1vhwA\/XvyNfMKn7VI\/AAAAAAAAeA4\/3cBzlnVstEkjuUCyNLjUOQRWBheFihvLACLcBGAsYHQ\/s320\/European_Journal_Pharmacology.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Patil, J. B., Kim, J., &amp; Jayaprakasha, G. K. (2010).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299910007569\">Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway<\/a>. European journal of pharmacology, 645(1-3), 70-78.<\/p>\n<p>Los compuestos bioactivos encontrados en muchas especies de plantas se han utilizado en la medicina ayurv\u00e9dica china, unani e india. Las evidencias acumulativas en estudios in vitro e in vivo que usan berberina demostraron propiedades anticancer\u00edgenas y antiinflamatorias en diferentes c\u00e9lulas cancerosas.<\/p>\n<p>En el presente estudio, un supuesto compuesto de muestra comercial se purific\u00f3 por t\u00e9cnicas cromatogr\u00e1ficas. La estructura del compuesto puro fue confirmada por estudios espectrosc\u00f3picos. La berberina purificada se prob\u00f3 contra el c\u00e1ncer de mama (MCF-7) y las c\u00e9lulas epiteliales de mama humanas normales (MCF-12F) durante 24, 48 y 72 ha varias concentraciones.<\/p>\n<p>Usando el ensayo MTT , la berberina exhibi\u00f3 un efecto citot\u00f3xico significativo en las c\u00e9lulas MCF-7 (P &lt; 0.01 ) sin afectar el crecimiento normal de las c\u00e9lulas epiteliales del seno a una concentraci\u00f3n de 25 \u03bcM. Sobre la base de estos resultados, las c\u00e9lulas MCF-7 se trataron con berberina 25 \u03bcM durante 48 y 72 h para estudios adicionales para ilustrar la inducci\u00f3n de apoptosis a trav\u00e9s de la distribuci\u00f3n del ciclo celular y la fragmentaci\u00f3n del ADN con electroforesis en gel de agarosa.<\/p>\n<p>La transferencia Western con c\u00e9lulas tratadas revel\u00f3 que la berberina induce la apoptosis en las c\u00e9lulas MCF-7 a trav\u00e9s de una v\u00eda dependiente de las mitocondrias al aumentar los niveles de citocromo c citoplasm\u00e1tico , la actividad de la caspasa-9 y la escisi\u00f3n de PARP al tiempo que disminuye los niveles de Bcl-2 . Adem\u00e1s, los resultados de inmunotransferencia demostraron que p53 y p27 estaban regulados, lo que sugiere que la barberina parece jugar un papel proapopt\u00f3tico en las c\u00e9lulas cancerosas.<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, la berberina inhibe la proliferaci\u00f3n de c\u00e9lulas de c\u00e1ncer de mama MCF-7 a trav\u00e9s de una v\u00eda apopt\u00f3tica dependiente de mitocondrias y caspasas . Es posible que la berberina sirva como un posible compuesto natural para la terapia del c\u00e1ncer de seno.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patil, J. B., Kim, J., &amp; Jayaprakasha, G. K. (2010).\u00a0Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. European journal of pharmacology, 645(1-3), 70-78. Los compuestos bioactivos encontrados en muchas especies de plantas se han utilizado en la medicina ayurv\u00e9dica china, unani e india. Las evidencias acumulativas en estudios in vitro e in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-114","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La berberina induce la apoptosis en las c\u00e9lulas de c\u00e1ncer de mama (MCF-7) a trav\u00e9s de la v\u00eda dependiente de las mitocondrias&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=114\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La berberina induce la apoptosis en las c\u00e9lulas de c\u00e1ncer de mama (MCF-7) a trav\u00e9s de la v\u00eda dependiente de las mitocondrias&quot; -\" \/>\n<meta property=\"og:description\" content=\"Patil, J. B., Kim, J., &amp; Jayaprakasha, G. K. (2010).\u00a0Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway. European journal of pharmacology, 645(1-3), 70-78. Los compuestos bioactivos encontrados en muchas especies de plantas se han utilizado en la medicina ayurv\u00e9dica china, unani e india. 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