{"id":117,"date":"2020-07-02T00:30:15","date_gmt":"2020-07-02T00:30:15","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=117"},"modified":"2020-07-02T14:22:08","modified_gmt":"2020-07-02T14:22:08","slug":"area-de-conocimiento-naturopatia-descriptiva-la-leptina-regula-la-diferenciacion-condrogenica-en-la-linea-celular-atdc5-a-traves-de-las-vias-jak-stat-y-mapk","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=117","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa leptina regula la diferenciaci\u00f3n condrog\u00e9nica en la l\u00ednea celular ATDC5 a trav\u00e9s de las v\u00edas JAK \/ STAT y MAPK\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-5Evj3R-NqWQ\/Xv3tNUpIyFI\/AAAAAAAAeCo\/ceNhp9AcVTcFL-lohOMtUGgBR7fGEjbzQCLcBGAsYHQ\/s1600\/Endocrine.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-5Evj3R-NqWQ\/Xv3tNUpIyFI\/AAAAAAAAeCo\/ceNhp9AcVTcFL-lohOMtUGgBR7fGEjbzQCLcBGAsYHQ\/s1600\/Endocrine.jpg\" border=\"0\" data-original-width=\"153\" data-original-height=\"203\" \/><\/a>Ben-Eliezer, M., Phillip, M., &amp; Gat-Yablonski, G. (2007).\u00a0<a href=\"http:\/\/link.springer.com\/article\/10.1007\/s12020-007-9025-y\">Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK\/STAT and MAPK pathways<\/a>.\u00a0<i>Endocrine<\/i>, 32(2), 235-244.<\/p>\n<p>FONDO: Se ha encontrado que la leptina, la hormona de la saciedad, afecta el desarrollo del cart\u00edlago de la placa de crecimiento.<\/p>\n<p>OBJETIVO: En el presente estudio, se analizaron algunas de las v\u00edas de transducci\u00f3n de se\u00f1ales que median la se\u00f1alizaci\u00f3n de leptina en la l\u00ednea celular condrog\u00e9nica ATDC5, un modelo para la osificaci\u00f3n endocondral.<\/p>\n<p>M\u00c9TODO: Para este prop\u00f3sito, se utilizaron PCR en tiempo real, transferencias de Western y t\u00e9cnicas de inmunofluorescencia.<\/p>\n<p>RESULTADOS: Se descubri\u00f3 que la leptina aumentaba la fosforilaci\u00f3n de ERK1 \/ 2, p38 y STAT3 de una manera dependiente del tiempo y la dosis. La inhibici\u00f3n espec\u00edfica de STAT3 o ERK1 \/ 2, pero no de P38, bloque\u00f3 el efecto estimulante de la leptina sobre los niveles de ARNm de col\u00e1geno tipo X. Adem\u00e1s, la leptina indujo la translocaci\u00f3n de ERK1 \/ 2 en el n\u00facleo, as\u00ed como la expresi\u00f3n de c-fos, lo que indica la activaci\u00f3n completa de esta cascada. No se observ\u00f3 fosforilaci\u00f3n de JNK inducida por leptina, aunque la leptina aument\u00f3 significativamente y r\u00e1pidamente los niveles de prote\u00edna JNK y los niveles de ARNm de c-jun. Adem\u00e1s, ERK5 se identific\u00f3 en estas c\u00e9lulas, pero no hubo un efecto aparente de la leptina ni en su fosforilaci\u00f3n ni en el nivel de prote\u00edna.<\/p>\n<p>CONCLUSI\u00d3N: El estudio indica que los efectos de la leptina en los condrocitos de la placa de crecimiento est\u00e1n mediados espec\u00edficamente por ERK1 \/ 2 y STAT3, mientras que P38 no es esencial para la expresi\u00f3n de col\u00e1geno tipo X inducida por leptina. Esta es la primera demostraci\u00f3n de que estas v\u00edas est\u00e1n involucradas en el crecimiento inducido por leptina.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ben-Eliezer, M., Phillip, M., &amp; Gat-Yablonski, G. (2007).\u00a0Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK\/STAT and MAPK pathways.\u00a0Endocrine, 32(2), 235-244. FONDO: Se ha encontrado que la leptina, la hormona de la saciedad, afecta el desarrollo del cart\u00edlago de la placa de crecimiento. OBJETIVO: En el presente estudio, se analizaron algunas de las v\u00edas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-117","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La leptina regula la diferenciaci\u00f3n condrog\u00e9nica en la l\u00ednea celular ATDC5 a trav\u00e9s de las v\u00edas JAK \/ STAT y MAPK&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=117\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La leptina regula la diferenciaci\u00f3n condrog\u00e9nica en la l\u00ednea celular ATDC5 a trav\u00e9s de las v\u00edas JAK \/ STAT y MAPK&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ben-Eliezer, M., Phillip, M., &amp; Gat-Yablonski, G. (2007).\u00a0Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK\/STAT and MAPK pathways.\u00a0Endocrine, 32(2), 235-244. FONDO: Se ha encontrado que la leptina, la hormona de la saciedad, afecta el desarrollo del cart\u00edlago de la placa de crecimiento. OBJETIVO: En el presente estudio, se analizaron algunas de las v\u00edas de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=117\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-02T00:30:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-02T14:22:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-5Evj3R-NqWQ\/Xv3tNUpIyFI\/AAAAAAAAeCo\/ceNhp9AcVTcFL-lohOMtUGgBR7fGEjbzQCLcBGAsYHQ\/s1600\/Endocrine.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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