{"id":27928,"date":"2019-07-20T00:30:17","date_gmt":"2019-07-20T00:30:17","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=27928"},"modified":"2019-07-20T00:30:17","modified_gmt":"2019-07-20T00:30:17","slug":"area-de-conocimiento-naturopatia-descriptiva-estres-oxidativo-en-el-melanoma-maligno-y-el-cancer-de-piel-no-melanoma","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=27928","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEstr\u00e9s oxidativo en el melanoma maligno y el c\u00e1ncer de piel no melanoma\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-Ggv4cLAnPFc\/XTIWVUMxzPI\/AAAAAAAAVvI\/-9VvLWztr10f-qASUWv7oj9Sgy2Mo0Z_wCLcBGAs\/s1600\/British_Journal_Dermatology%252C.png\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-Ggv4cLAnPFc\/XTIWVUMxzPI\/AAAAAAAAVvI\/-9VvLWztr10f-qASUWv7oj9Sgy2Mo0Z_wCLcBGAs\/s320\/British_Journal_Dermatology%252C.png\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Sander, C. S., Hamm, F., Elsner, P., &amp; Thiele, J. J. (2003).&nbsp;<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1046\/j.1365-2133.2003.05303.x\">Oxidative stress in malignant melanoma and non\u2010melanoma skin cancer<\/a>.&nbsp;<em>British Journal of Dermatology,<\/em>&nbsp;148(5), 913-922.<\/p>\n\n\n\n<p>ANTECEDENTES: La radiaci\u00f3n solar ultravioleta (UV) se considera un factor etiol\u00f3gico importante en el melanoma y el c\u00e1ncer de piel no melanoma. Un creciente cuerpo de evidencia indica que el estr\u00e9s oxidativo est\u00e1 involucrado en la fotocarcinog\u00e9nesis. Sin embargo, todav\u00eda faltan datos in vivo para la piel humana. Las especies reactivas de ox\u00edgeno participan en una serie de procesos fisiopatol\u00f3gicos que incluyen da\u00f1o en el ADN y la peroxidaci\u00f3n de l\u00edpidos (LPO) y se consideran un factor clave en la progresi\u00f3n del tumor.<\/p>\n\n\n\n<p>OBJETIVOS: Planteamos la hip\u00f3tesis de que en el c\u00e1ncer de piel humano se altera el equilibrio redox natural y que este desequilibrio puede dar como resultado una acumulaci\u00f3n de productos LPO.<\/p>\n\n\n\n<p>M\u00c9TODOS: Para probar esto, se compararon las biopsias de la piel del melanoma de diseminaci\u00f3n superficial con los naevi melanoc\u00edticos benignos de la misma edad y los controles sanos j\u00f3venes. Adem\u00e1s, se investigaron los c\u00e1nceres de piel no melanoma (carcinoma de c\u00e9lulas basales, carcinoma de c\u00e9lulas escamosas) y la queratosis act\u00ednica ( n \u2003= 18 cada uno). La expresi\u00f3n de las enzimas antioxidantes, la super\u00f3xido dismutasa de cobre-zinc, la super\u00f3xido dismutasa de manganeso y la catalasa se analiz\u00f3 mediante t\u00e9cnicas inmunohistoqu\u00edmicas. Para detectar productos LPO, se visualiz\u00f3 malondialdeh\u00eddo unido a prote\u00ednas (MDA).<\/p>\n\n\n\n<p>RESULTADOS: En las biopsias de melanoma humano, se encontr\u00f3 una sobreexpresi\u00f3n significativa de las enzimas antioxidantes cuando se compar\u00f3 con el tejido no tumoral circundante, el nebi melanoc\u00edtico benigno y los controles j\u00f3venes. Curiosamente, el marcador LPO MDA se increment\u00f3 significativamente en el tejido del melanoma. La MDA se localiz\u00f3 no solo en las c\u00e9lulas t\u00edpicas de melanoma, sino que tambi\u00e9n ocurri\u00f3 en los queratinocitos circundantes. En contraste, se encontr\u00f3 un equilibrio antioxidante gravemente alterado con enzimas antioxidantes disminuidas en los tumores no melanoma, mientras que la MDA se elev\u00f3 solo en los carcinomas de c\u00e9lulas escamosas.<\/p>\n\n\n\n<p>CONCLUSIONES: Estos hallazgos indican que el estr\u00e9s oxidativo puede desempe\u00f1ar diferentes funciones en la patog\u00e9nesis de los c\u00e1nceres de piel en humanos. En el c\u00e1ncer de piel no melanoma, una defensa antioxidante disminuida causada por la exposici\u00f3n cr\u00f3nica a los rayos UV podr\u00eda contribuir a la carcinog\u00e9nesis de m\u00faltiples etapas, mientras que las c\u00e9lulas de melanoma exhiben un aumento del estr\u00e9s oxidativo que podr\u00eda da\u00f1ar el tejido circundante y, por lo tanto, respaldar la progresi\u00f3n de la met\u00e1stasis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sander, C. S., Hamm, F., Elsner, P., &amp; Thiele, J. J. (2003).&nbsp;Oxidative stress in malignant melanoma and non\u2010melanoma skin cancer.&nbsp;British Journal of Dermatology,&nbsp;148(5), 913-922. ANTECEDENTES: La radiaci\u00f3n solar ultravioleta (UV) se considera un factor etiol\u00f3gico importante en el melanoma y el c\u00e1ncer de piel no melanoma. Un creciente cuerpo de evidencia indica que el estr\u00e9s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-27928","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo en el melanoma maligno y el c\u00e1ncer de piel no melanoma&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=27928\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo en el melanoma maligno y el c\u00e1ncer de piel no melanoma&quot; -\" \/>\n<meta property=\"og:description\" content=\"Sander, C. S., Hamm, F., Elsner, P., &amp; Thiele, J. J. (2003).&nbsp;Oxidative stress in malignant melanoma and non\u2010melanoma skin cancer.&nbsp;British Journal of Dermatology,&nbsp;148(5), 913-922. ANTECEDENTES: La radiaci\u00f3n solar ultravioleta (UV) se considera un factor etiol\u00f3gico importante en el melanoma y el c\u00e1ncer de piel no melanoma. Un creciente cuerpo de evidencia indica que el estr\u00e9s [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=27928\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-20T00:30:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-Ggv4cLAnPFc\/XTIWVUMxzPI\/AAAAAAAAVvI\/-9VvLWztr10f-qASUWv7oj9Sgy2Mo0Z_wCLcBGAs\/s320\/British_Journal_Dermatology%252C.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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