{"id":27993,"date":"2019-07-21T00:30:25","date_gmt":"2019-07-21T00:30:25","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=27993"},"modified":"2019-07-21T00:30:25","modified_gmt":"2019-07-21T00:30:25","slug":"27993","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=27993","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl papel de la COX-2 en la inflamaci\u00f3n intestinal y el c\u00e1ncer colorrectal\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-QG4ltRK35s0\/XTNzRFcUWAI\/AAAAAAAAVwg\/xOqSoSD4SyYTxkW95rTEGR9uaKHHUFziACLcBGAs\/s1600\/Oncogene.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-QG4ltRK35s0\/XTNzRFcUWAI\/AAAAAAAAVwg\/xOqSoSD4SyYTxkW95rTEGR9uaKHHUFziACLcBGAs\/s1600\/Oncogene.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Wang, D., &amp; DuBois, R. N. (2010).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3181054\/\">The role of COX-2 in intestinal inflammation and colorectal cancer<\/a>.&nbsp;<em>Oncogene<\/em>, 29(6), 781.<\/p>\n\n\n\n<p>El c\u00e1ncer colorrectal (CCR) es una enfermedad heterog\u00e9nea, que incluye al menos tres formas principales: hereditaria, espor\u00e1dica y CCR asociada a colitis. Un gran cuerpo de evidencia indica que las mutaciones gen\u00e9ticas, los cambios epigen\u00e9ticos, la inflamaci\u00f3n cr\u00f3nica, la dieta y el estilo de vida son los factores de riesgo de CCR.&nbsp;<\/p>\n\n\n\n<p>Debido a que se encontr\u00f3 una expresi\u00f3n elevada de la ciclooxigenasa-2 (COX-2) en la mayor\u00eda de los tejidos de c\u00e1ncer colorrectal y se asocia con una peor supervivencia entre los pacientes con CCR, los investigadores han tratado de evaluar los efectos de los f\u00e1rmacos antiinflamatorios no esteroideos (AINE) y los inhibidores selectivos de la COX-2 (COXIBs) en prevenci\u00f3n y tratamiento de CCR.<\/p>\n\n\n\n<p>Los estudios epidemiol\u00f3gicos, los ensayos cl\u00ednicos y los experimentos con animales indican que los AINE se encuentran entre los agentes quimiopreventivos m\u00e1s prometedores para esta enfermedad. Los AINE ejercen sus efectos antiinflamatorios y antitumorales principalmente al reducir la producci\u00f3n de prostaglandinas mediante la inhibici\u00f3n de la actividad de la COX-2. En esta revisi\u00f3n, destacamos los avances en nuestra comprensi\u00f3n de las funciones de la COX-2 en el CCR y la enfermedad intestinal inflamatoria (EII).&nbsp;<\/p>\n\n\n\n<p>Estos datos recientes proporcionan una justificaci\u00f3n para reevaluar COX-2 como marcador pron\u00f3stico y predictivo en una amplia variedad de tumores malignos y para renovar el inter\u00e9s en evaluar los beneficios relativos y el riesgo de inhibidores de COX-2 en pacientes seleccionados adecuadamente para la prevenci\u00f3n del c\u00e1ncer y tratamiento.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang, D., &amp; DuBois, R. N. (2010).&nbsp;The role of COX-2 in intestinal inflammation and colorectal cancer.&nbsp;Oncogene, 29(6), 781. El c\u00e1ncer colorrectal (CCR) es una enfermedad heterog\u00e9nea, que incluye al menos tres formas principales: hereditaria, espor\u00e1dica y CCR asociada a colitis. Un gran cuerpo de evidencia indica que las mutaciones gen\u00e9ticas, los cambios epigen\u00e9ticos, la inflamaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-27993","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El papel de la COX-2 en la inflamaci\u00f3n intestinal y el c\u00e1ncer colorrectal&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=27993\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El papel de la COX-2 en la inflamaci\u00f3n intestinal y el c\u00e1ncer colorrectal&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wang, D., &amp; DuBois, R. N. (2010).&nbsp;The role of COX-2 in intestinal inflammation and colorectal cancer.&nbsp;Oncogene, 29(6), 781. El c\u00e1ncer colorrectal (CCR) es una enfermedad heterog\u00e9nea, que incluye al menos tres formas principales: hereditaria, espor\u00e1dica y CCR asociada a colitis. Un gran cuerpo de evidencia indica que las mutaciones gen\u00e9ticas, los cambios epigen\u00e9ticos, la inflamaci\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=27993\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-21T00:30:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-QG4ltRK35s0\/XTNzRFcUWAI\/AAAAAAAAVwg\/xOqSoSD4SyYTxkW95rTEGR9uaKHHUFziACLcBGAs\/s1600\/Oncogene.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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