{"id":28186,"date":"2019-07-24T00:30:17","date_gmt":"2019-07-24T00:30:17","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=28186"},"modified":"2019-07-24T00:30:17","modified_gmt":"2019-07-24T00:30:17","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-las-flavonas-y-flavonoles-ejercen-efectos-citotoxicos-en-una-linea-celular-de-adenocarcinoma-esofagico-humano-oe33-al-provoca","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=28186","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLas flavonas y flavonoles ejercen efectos citot\u00f3xicos en una l\u00ednea celular de adenocarcinoma esof\u00e1gico humano (OE33) al provocar la detenci\u00f3n de G2 \/ M e inducir la apoptosis\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-99oUGtrkpGI\/XTdn9960dvI\/AAAAAAAAV1w\/K0LQrWEi-JUCfM9xRw64bINt9ml9u72qACLcBGAs\/s1600\/Food_Chemical%2BToxicology.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-99oUGtrkpGI\/XTdn9960dvI\/AAAAAAAAV1w\/K0LQrWEi-JUCfM9xRw64bINt9ml9u72qACLcBGAs\/s1600\/Food_Chemical%2BToxicology.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Zhang, Q., Zhao, X. H., &amp; Wang, Z. J. (2008).&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0278691508000677\">Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2\/M arrest and inducing apoptosis<\/a>.&nbsp;<em>Food and Chemical Toxicology<\/em>, 46(6), 2042-2053.&nbsp;<\/p>\n\n\n\n<p>Se ha demostrado que los flavonoides en la dieta ejercen una citotoxicidad espec\u00edfica hacia algunas c\u00e9lulas cancerosas, pero los mecanismos moleculares precisos a\u00fan no se conocen por completo.&nbsp;<\/p>\n\n\n\n<p>En nuestro estudio, se compararon los efectos citot\u00f3xicos de flavonoles y flavonoles relacionados estructuralmente en una l\u00ednea celular de adenocarcinoma de es\u00f3fago humano (OE33), y se exploraron los mecanismos moleculares responsables de sus efectos citot\u00f3xicos.&nbsp;<\/p>\n\n\n\n<p>Los resultados del ensayo MTT mostraron que las flavonas (luteolina, apigenina, crisina) y los flavonoles (quercetina, kaempferol, miricetina) fueron capaces de inducir citotoxicidad en c\u00e9lulas OE33 de una manera dependiente de la dosis y del tiempo, y la potencia citot\u00f3xica de estos compuestos estaba en el orden de quercetina &gt; luteolina &gt; crisina &gt; kaempferol &gt; apigenina &gt; myricetina.&nbsp;<\/p>\n\n\n\n<p>La citometr\u00eda de flujo y el an\u00e1lisis de fragmentaci\u00f3n de ADN indicaron que la citotoxicidad inducida por flavonoides y flavonoles estaba mediada por la detenci\u00f3n del ciclo celular G2 \/ M y la apoptosis. Adem\u00e1s, la expresi\u00f3n de genes relacionados con la detenci\u00f3n del ciclo celular y la apoptosis se evalu\u00f3 mediante microarreglo de oligonucle\u00f3tidos, RT-PCR en tiempo real y transferencia de Western.&nbsp;<\/p>\n\n\n\n<p>Se encontr\u00f3 que el tratamiento de las c\u00e9lulas OE33 con flavonoles y flavonoides causaba la detenci\u00f3n G2 \/ M a trav\u00e9s de la regulaci\u00f3n positiva de GADD45\u03b2 y 14-3-3\u03c3 y la baja regulaci\u00f3n de ciclina B1 en los niveles de ARNm y prote\u00edna, y induc\u00eda mitocondrial independiente de p53. apoptosis mediada por la regulaci\u00f3n positiva de PIG3 y la escisi\u00f3n de caspasa-9 y caspasa-3.&nbsp;<\/p>\n\n\n\n<p>Los resultados del an\u00e1lisis western blot mostraron adem\u00e1s que el aumento de la traducci\u00f3n o estabilidad de la prote\u00edna p63 y p73 podr\u00eda contribuir a la regulaci\u00f3n de GADD45\u03b2, 14-3-3\u03c3, ciclina B1 y PIG3.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhang, Q., Zhao, X. H., &amp; Wang, Z. J. (2008).&nbsp;Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2\/M arrest and inducing apoptosis.&nbsp;Food and Chemical Toxicology, 46(6), 2042-2053.&nbsp; Se ha demostrado que los flavonoides en la dieta ejercen una citotoxicidad espec\u00edfica hacia algunas c\u00e9lulas cancerosas, pero los mecanismos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-28186","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Las flavonas y flavonoles ejercen efectos citot\u00f3xicos en una l\u00ednea celular de adenocarcinoma esof\u00e1gico humano (OE33) al provocar la detenci\u00f3n de G2 \/ M e inducir la apoptosis&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=28186\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Las flavonas y flavonoles ejercen efectos citot\u00f3xicos en una l\u00ednea celular de adenocarcinoma esof\u00e1gico humano (OE33) al provocar la detenci\u00f3n de G2 \/ M e inducir la apoptosis&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhang, Q., Zhao, X. H., &amp; Wang, Z. J. (2008).&nbsp;Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2\/M arrest and inducing apoptosis.&nbsp;Food and Chemical Toxicology, 46(6), 2042-2053.&nbsp; Se ha demostrado que los flavonoides en la dieta ejercen una citotoxicidad espec\u00edfica hacia algunas c\u00e9lulas cancerosas, pero los mecanismos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=28186\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-24T00:30:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-99oUGtrkpGI\/XTdn9960dvI\/AAAAAAAAV1w\/K0LQrWEi-JUCfM9xRw64bINt9ml9u72qACLcBGAs\/s1600\/Food_Chemical%2BToxicology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta 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