{"id":28421,"date":"2019-06-30T00:30:37","date_gmt":"2019-06-29T22:30:37","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=28421"},"modified":"2020-07-02T19:44:23","modified_gmt":"2020-07-02T19:44:23","slug":"area-de-conocimiento-naturopatia-descriptiva-el-papel-del-estres-oxidativo-en-la-enfermedad-de-huntington-son-los-antioxidantes-buenos-candidatos-terapeuticos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=28421","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl papel del estr\u00e9s oxidativo en la enfermedad de Huntington: \u00bfson los antioxidantes buenos candidatos terap\u00e9uticos?\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Wr2xgXQ62F0\/XRi_6uQk9YI\/AAAAAAAAVVo\/QwYDyO0kZBc5ufnTxTAkUjL4ynroaPknwCLcBGAs\/s1600\/Current_drug%2Btargets.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Wr2xgXQ62F0\/XRi_6uQk9YI\/AAAAAAAAVVo\/QwYDyO0kZBc5ufnTxTAkUjL4ynroaPknwCLcBGAs\/s1600\/Current_drug%2Btargets.jpg\" border=\"0\" data-original-width=\"132\" data-original-height=\"172\" \/><\/a>Gil-Mohapel, J., S Brocardo, P., &amp; R Christie, B. (2014). <a href=\"https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.researchgate.net\/profile\/Brian_Christie\/publication\/225684432_Do_new_neurons_have_a_functional_role_in_the_adult_hippocampus\/links\/02e7e532075e3e2da4000000\/Do-new-neurons-have-a-functional-role-in-the-adult-hippocampus.pdf&amp;hl=es&amp;sa=T&amp;oi=gsb-gga&amp;ct=res&amp;cd=0&amp;ei=Q6vwWvyGNYjYyQTymJqoBw&amp;scisig=AAGBfm1lTJHs64Js4WPqna_Me17u8g6XiQ\">The role of oxidative stress in Huntington\u2019s disease: are antioxidants good therapeutic candidates?<\/a>\u00a0<em>Current drug targets<\/em>, 15(4), 454-468.<\/p>\n<p>La enfermedad de Huntington (HD) es el trastorno neurodegenerativo poliglutamina m\u00e1s com\u00fan en los seres humanos, y es causada por una mutaci\u00f3n de una expansi\u00f3n inestable de repeticiones de CAG dentro de la regi\u00f3n codificante del gen HD, que expresa la prote\u00edna huntingtina. Aunque la prote\u00edna anormal se expresa de forma ubicua en todo el organismo, la degeneraci\u00f3n celular se produce principalmente en el cerebro y, predominantemente, en el cuerpo estriado y la corteza.<\/p>\n<p>Los mecanismos que explican esta muerte neuronal selectiva son multifac\u00e9ticos en su naturaleza y varias l\u00edneas de evidencia sugieren que la disfunci\u00f3n mitocondrial, la sobreproducci\u00f3n de especies reactivas de ox\u00edgeno (ROS) y el estr\u00e9s oxidativo (un desequilibrio entre los sistemas pro-oxidante y antioxidante que resulta en un da\u00f1o oxidativo a las prote\u00ednas). , l\u00edpidos y ADN) podr\u00edan desempe\u00f1ar papeles importantes. A trav\u00e9s del tiempo, esto puede resultar en la muerte de las poblaciones neuronales afectadas.<\/p>\n<p>En este art\u00edculo de revisi\u00f3n, presentamos una descripci\u00f3n general de los estudios precl\u00ednicos y cl\u00ednicos que han indicado un v\u00ednculo entre el estr\u00e9s oxidativo, la neurodegeneraci\u00f3n y la muerte celular en la EH. Tambi\u00e9n discutimos c\u00f3mo los cambios en la producci\u00f3n de ROS afectan la supervivencia neuronal, destacando la evidencia del uso de antioxidantes, incluidos los \u00e1cidos grasos esenciales, la coenzima Q10 y la creatina, como posibles estrategias terap\u00e9uticas para el tratamiento de este trastorno neurodegenerativo devastador.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gil-Mohapel, J., S Brocardo, P., &amp; R Christie, B. (2014). The role of oxidative stress in Huntington\u2019s disease: are antioxidants good therapeutic candidates?\u00a0Current drug targets, 15(4), 454-468. La enfermedad de Huntington (HD) es el trastorno neurodegenerativo poliglutamina m\u00e1s com\u00fan en los seres humanos, y es causada por una mutaci\u00f3n de una expansi\u00f3n inestable de repeticiones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-28421","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El papel del estr\u00e9s oxidativo en la enfermedad de Huntington: \u00bfson los antioxidantes buenos candidatos terap\u00e9uticos?&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=28421\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El papel del estr\u00e9s oxidativo en la enfermedad de Huntington: \u00bfson los antioxidantes buenos candidatos terap\u00e9uticos?&quot; -\" \/>\n<meta property=\"og:description\" content=\"Gil-Mohapel, J., S Brocardo, P., &amp; R Christie, B. (2014). The role of oxidative stress in Huntington\u2019s disease: are antioxidants good therapeutic candidates?\u00a0Current drug targets, 15(4), 454-468. La enfermedad de Huntington (HD) es el trastorno neurodegenerativo poliglutamina m\u00e1s com\u00fan en los seres humanos, y es causada por una mutaci\u00f3n de una expansi\u00f3n inestable de repeticiones [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=28421\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-29T22:30:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-02T19:44:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-Wr2xgXQ62F0\/XRi_6uQk9YI\/AAAAAAAAVVo\/QwYDyO0kZBc5ufnTxTAkUjL4ynroaPknwCLcBGAs\/s1600\/Current_drug%2Btargets.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" 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