{"id":28518,"date":"2019-07-30T02:30:25","date_gmt":"2019-07-30T00:30:25","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=28518"},"modified":"2019-07-30T02:30:25","modified_gmt":"2019-07-30T00:30:25","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-sensibilidad-de-las-celulas-de-cancer-mutadas-de-tp53-a-la-genisteina-de-fitoestrogenos-esta-asociada-con-la-inhibicion-dire","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=28518","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa sensibilidad de las c\u00e9lulas de c\u00e1ncer mutadas de TP53 a la geniste\u00edna de fitoestr\u00f3genos est\u00e1 asociada con la inhibici\u00f3n directa de la actividad de Plk1\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-2MMKEc8q--w\/XT22IQp7d8I\/AAAAAAAAV9g\/UQSPAeQ3Ajs-hZS1XIl6rKpEdxiCxHqiwCLcBGAs\/s1600\/Journal_cellular%2Bphysiology.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-2MMKEc8q--w\/XT22IQp7d8I\/AAAAAAAAV9g\/UQSPAeQ3Ajs-hZS1XIl6rKpEdxiCxHqiwCLcBGAs\/s1600\/Journal_cellular%2Bphysiology.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Shin, S. B., Woo, S. U., Chin, Y. W., Jang, Y. J., &amp; Yim, H. (2017).&nbsp;<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jcp.25680\">Sensitivity of TP53\u2010Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity<\/a>.&nbsp;<em>Journal of cellular physiology<\/em>, 232(10), 2818-2828.<\/p>\n\n\n\n<p>Polo-like kinase 1 (Plk1), una quinasa mit\u00f3tica conservada de Ser \/ Thr, ha sido identificada como un objetivo prometedor para el desarrollo de f\u00e1rmacos contra el c\u00e1ncer porque su sobreexpresi\u00f3n est\u00e1 relacionada con la malignidad.&nbsp;<\/p>\n\n\n\n<p>Aqu\u00ed, encontramos que la geniste\u00edna, una isoflavona, inhibe la actividad de la quinasa Plk1 directamente. Anteriormente, el fen\u00f3meno de alteraci\u00f3n mit\u00f3tica inducido por el tratamiento con geniste\u00edna no se explicaba completamente por su efecto inhibitorio sobre el EGFR.&nbsp;<\/p>\n\n\n\n<p>En los ensayos de perfiles de quinasa, mostr\u00f3 selectividad con respecto a un panel de quinasas, incluido el EGFR. El tratamiento con geniste\u00edna indujo la muerte celular de forma dependiente de la concentraci\u00f3n en c\u00e9lulas cancerosas de diversos or\u00edgenes tisulares, pero no en c\u00e9lulas no transformadas, como las c\u00e9lulas hTERT-RPE o MCF10A.&nbsp;<\/p>\n\n\n\n<p>Tambi\u00e9n observamos que la geniste\u00edna tend\u00eda a ser m\u00e1s selectiva contra las c\u00e9lulas cancerosas con mutaciones en el gen TP53. Las c\u00e9lulas LNCaP y NCI-H460 eliminadas por TP53 que usan ARNhc dirigidas a TP53 humanas fueron m\u00e1s sensibles a la muerte celular por el tratamiento de geniste\u00edna. Adem\u00e1s, la geniste\u00edna indujo un paro mit\u00f3tico al inhibir la actividad de Plk1 y, en consecuencia, condujo a una cat\u00e1strofe mit\u00f3tica y apoptosis.&nbsp;<\/p>\n\n\n\n<p>Estos datos sugieren que la geniste\u00edna puede ser un prometedor f\u00e1rmaco anticanceroso candidato debido a su actividad inhibitoria contra Plk1, as\u00ed como a EGFR y su eficacia frente a las c\u00e9lulas cancerosas, especialmente aquellas con mutaci\u00f3n p53.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shin, S. B., Woo, S. U., Chin, Y. W., Jang, Y. J., &amp; Yim, H. (2017).&nbsp;Sensitivity of TP53\u2010Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.&nbsp;Journal of cellular physiology, 232(10), 2818-2828. Polo-like kinase 1 (Plk1), una quinasa mit\u00f3tica conservada de Ser \/ Thr, ha sido identificada como un objetivo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-28518","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La sensibilidad de las c\u00e9lulas de c\u00e1ncer mutadas de TP53 a la geniste\u00edna de fitoestr\u00f3genos est\u00e1 asociada con la inhibici\u00f3n directa de la actividad de Plk1&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=28518\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La sensibilidad de las c\u00e9lulas de c\u00e1ncer mutadas de TP53 a la geniste\u00edna de fitoestr\u00f3genos est\u00e1 asociada con la inhibici\u00f3n directa de la actividad de Plk1&quot; -\" \/>\n<meta property=\"og:description\" content=\"Shin, S. B., Woo, S. U., Chin, Y. W., Jang, Y. J., &amp; Yim, H. (2017).&nbsp;Sensitivity of TP53\u2010Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.&nbsp;Journal of cellular physiology, 232(10), 2818-2828. Polo-like kinase 1 (Plk1), una quinasa mit\u00f3tica conservada de Ser \/ Thr, ha sido identificada como un objetivo [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=28518\" \/>\n<meta property=\"article:published_time\" content=\"2019-07-30T00:30:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-2MMKEc8q--w\/XT22IQp7d8I\/AAAAAAAAV9g\/UQSPAeQ3Ajs-hZS1XIl6rKpEdxiCxHqiwCLcBGAs\/s1600\/Journal_cellular%2Bphysiology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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