{"id":28862,"date":"2019-08-04T06:30:25","date_gmt":"2019-08-04T04:30:25","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=28862"},"modified":"2019-08-04T06:30:25","modified_gmt":"2019-08-04T04:30:25","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-efectos-anticancerigenos-de-la-baicaleina-en-las-celulas-de-carcinoma-hepatocelular","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=28862","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos anticancer\u00edgenos de la baicale\u00edna en las c\u00e9lulas de carcinoma hepatocelular\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-lNF2w4dmbhM\/XUbPGqQpa3I\/AAAAAAAAWGI\/iivMEIY_3wkgyQWUYuGetPsFST0NHqZzQCLcBGAs\/s1600\/Phytotherapy_Research.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-lNF2w4dmbhM\/XUbPGqQpa3I\/AAAAAAAAWGI\/iivMEIY_3wkgyQWUYuGetPsFST0NHqZzQCLcBGAs\/s1600\/Phytotherapy_Research.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Zheng, Y. H., Yin, L. H., Grahn, T. H. M., Ye, A. F., Zhao, Y. R., &amp; Zhang, Q. Y. (2014). <a href=\"http:\/\/www.wzhospital.cn\/wyyyweb\/kjk\/keyanguanli\/keyanketi\/SCI%E8%AE%BA%E6%96%87%E6%B1%87%E6%80%BB\/%E6%B8%A9%E4%B8%80%E5%8C%BBSCI(%E6%9C%88%E5%88%9D%E6%9B%B4%E6%96%B0).files\/pdf\/24596136.pdf\">Anticancer effects of baicalein on hepatocellular carcinoma cells<\/a>. <em>Phytotherapy Research<\/em>, 28(9), 1342-1348.<\/p>\n\n\n\n<p>\n El potencial terap\u00e9utico de la baicale\u00edna contra las c\u00e9lulas de \nhepatoma se evalu\u00f3 in vitro e in vivo. En los ensayos de viabilidad \ncelular, la baicale\u00edna mostr\u00f3 una citotoxicidad significativa contra las\n l\u00edneas celulares de carcinoma hepatocelular H22, Bel-7404 y Hep G2 y \ncitotoxicidad moderada contra hepatocitos humanos inmortalizados. <\/p>\n\n\n\n<p>La  baicale\u00edna indujo la detenci\u00f3n de la fase G0 \/ G1 en c\u00e9lulas de  carcinoma hepatocelular, inhibi\u00f3 la AKT y promovi\u00f3 la degradaci\u00f3n de  \u03b2-catenina y ciclina D1 sin la activaci\u00f3n de GSK-3\u03b2. Adem\u00e1s, la  baicale\u00edna inhibi\u00f3 significativamente el crecimiento del tumor de  xenoinjerto H22 sin causar efectos adversos obvios sobre el peso o los  \u00edndices de peso del h\u00edgado y el bazo en ratones ICR. El an\u00e1lisis  inmunohistoqu\u00edmico mostr\u00f3 que la inhibici\u00f3n del crecimiento tumoral en  ratones tratados con baicale\u00edna se asoci\u00f3 con una disminuci\u00f3n de la  expresi\u00f3n de AKT, \u03b2-catenina y ciclina D1 ex vivo. <\/p>\n\n\n\n<p>Nuestros datos  indican que la baicale\u00edna podr\u00eda regular la transcripci\u00f3n de la ciclina  D1 a trav\u00e9s de un mecanismo dependiente de \u03b2-catenina, lo que lleva a la  detenci\u00f3n del ciclo celular en la fase G0 \/ G1 y a la proliferaci\u00f3n  celular cancerosa. Estos resultados sugieren que la baicale\u00edna es un candidato potencial para el tratamiento del carcinoma hepatocelular.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zheng, Y. H., Yin, L. H., Grahn, T. H. M., Ye, A. F., Zhao, Y. R., &amp; Zhang, Q. Y. (2014). Anticancer effects of baicalein on hepatocellular carcinoma cells. Phytotherapy Research, 28(9), 1342-1348. El potencial terap\u00e9utico de la baicale\u00edna contra las c\u00e9lulas de hepatoma se evalu\u00f3 in vitro e in vivo. En los ensayos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-28862","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos anticancer\u00edgenos de la baicale\u00edna en las c\u00e9lulas de carcinoma hepatocelular&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=28862\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos anticancer\u00edgenos de la baicale\u00edna en las c\u00e9lulas de carcinoma hepatocelular&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zheng, Y. H., Yin, L. H., Grahn, T. H. M., Ye, A. F., Zhao, Y. R., &amp; Zhang, Q. Y. (2014). Anticancer effects of baicalein on hepatocellular carcinoma cells. Phytotherapy Research, 28(9), 1342-1348. El potencial terap\u00e9utico de la baicale\u00edna contra las c\u00e9lulas de hepatoma se evalu\u00f3 in vitro e in vivo. 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