{"id":28932,"date":"2019-08-06T00:30:06","date_gmt":"2019-08-05T22:30:06","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=28932"},"modified":"2019-08-06T00:30:06","modified_gmt":"2019-08-05T22:30:06","slug":"area-de-conocimiento-naturopatia-descriptiva-la-acumulacion-de-testosterona-en-las-celulas-de-cancer-de-prostata-se-ve-reforzada-por-la-difusion-facilitada","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=28932","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\u00bb"},"content":{"rendered":"\n<p> <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-E0wDiZ5f4ck\/XUggys0dnkI\/AAAAAAAAWIs\/YSLscE1Nt3MrUXtj9Yi9ENoRWaGWgUUmgCLcBGAs\/s1600\/Prostate.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-E0wDiZ5f4ck\/XUggys0dnkI\/AAAAAAAAWIs\/YSLscE1Nt3MrUXtj9Yi9ENoRWaGWgUUmgCLcBGAs\/s1600\/Prostate.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Kaipainen, A, Zhang, A, Gil da Costa, RM, et al.&nbsp;<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/pros.23874\">Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion<\/a>.&nbsp;<em>The Prostate.<\/em>&nbsp;2019; 1\u2010 13.&nbsp;<br><\/p>\n\n\n\n<p>FONDO: La testosterona es un impulsor del crecimiento del c\u00e1ncer de pr\u00f3stata (PC) a trav\u00e9s de la activaci\u00f3n mediada por ligando del receptor de andr\u00f3genos (AR). Los tumores que han escapado de la privaci\u00f3n de andr\u00f3genos sist\u00e9micos, los c\u00e1nceres de pr\u00f3stata resistentes a la castraci\u00f3n (CRPC), tienen niveles intratumorales medibles de testosterona, lo que sugiere que un mecanismo de resistencia todav\u00eda depende del crecimiento simulado por andr\u00f3genos. Sin embargo, la activaci\u00f3n de AR requiere una concentraci\u00f3n intracelular \u00f3ptima de andr\u00f3genos, una situaci\u00f3n desafiada por las bajas concentraciones de testosterona circulante. En particular, las c\u00e9lulas PC pueden optimizar sus niveles de andr\u00f3genos al regular la expresi\u00f3n de las enzimas del metabolismo de esteroides que convierten los precursores de andr\u00f3genos en andr\u00f3genos. Aqu\u00ed proponemos que la entrada de testosterona en la c\u00e9lula podr\u00eda ser otro punto de control.<\/p>\n\n\n\n<p>METODOS: Para determinar si la testosterona entra en las c\u00e9lulas a trav\u00e9s de un transportador, se realiz\u00f3 in vitro 3 ensayos de captaci\u00f3n de H-testosterona en LNCaP y andr\u00f3geno dependiente de andr\u00f3genos y c\u00e9lulas PC3 AR-independientes. Para determinar si el mecanismo de absorci\u00f3n depend\u00eda de un gradiente de concentraci\u00f3n, modificamos los niveles de UGT2B17 en las c\u00e9lulas LNCaP y medimos los niveles de andr\u00f3genos mediante espectrometr\u00eda de extracci\u00f3n l\u00edquido-l\u00edquido-espectrometr\u00eda de masas. Tambi\u00e9n analizamos met\u00e1stasis CRPC para la expresi\u00f3n de AKR1C3 para determinar si esta enzima que convierte los andr\u00f3genos suprarrenales en testosterona estaba presente en el estroma tumoral (microambiente) adem\u00e1s de su expresi\u00f3n en el epitelio tumoral.<\/p>\n\n\n\n<p>RESULTADOS: La absorci\u00f3n de testosterona sigui\u00f3 un gradiente de concentraci\u00f3n, pero a diferencia de la difusi\u00f3n pasiva, fue saturable y dependiente de la temperatura, lo que sugiere un transporte facilitado. La supresi\u00f3n de UGT2B17 para derogar un gradiente de testosterona redujo el transporte de testosterona, mientras que la sobreexpresi\u00f3n de la enzima lo mejor\u00f3. El transporte facilitado sugiere una ruta paracrina de la absorci\u00f3n de testosterona para mantener niveles intracelulares \u00f3ptimos. Encontramos que AKR1C3 se expres\u00f3 en el microambiente tumoral de met\u00e1stasis de CRPC adem\u00e1s de las c\u00e9lulas epiteliales y el patr\u00f3n de abundancia relativa de la enzima en el epitelio frente al estroma vari\u00f3 sustancialmente entre los sitios metast\u00e1sicos.<\/p>\n\n\n\n<p>CONCLUSIONES: Nuestros hallazgos sugieren que, adem\u00e1s del transporte de testosterona y el metabolismo del epitelio tumoral, la testosterona tambi\u00e9n podr\u00eda ser producida por componentes del microambiente tumoral. La absorci\u00f3n de testosterona facilitada por las c\u00e9lulas tumorales apoya un mecanismo celular no aut\u00f3nomo para la se\u00f1alizaci\u00f3n de testosterona en CRPC.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kaipainen, A, Zhang, A, Gil da Costa, RM, et al.&nbsp;Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.&nbsp;The Prostate.&nbsp;2019; 1\u2010 13.&nbsp; FONDO: La testosterona es un impulsor del crecimiento del c\u00e1ncer de pr\u00f3stata (PC) a trav\u00e9s de la activaci\u00f3n mediada por ligando del receptor de andr\u00f3genos (AR). Los tumores que han escapado de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-28932","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada&quot; -\" \/>\n<meta property=\"og:description\" content=\"Kaipainen, A, Zhang, A, Gil da Costa, RM, et al.&nbsp;Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.&nbsp;The Prostate.&nbsp;2019; 1\u2010 13.&nbsp; FONDO: La testosterona es un impulsor del crecimiento del c\u00e1ncer de pr\u00f3stata (PC) a trav\u00e9s de la activaci\u00f3n mediada por ligando del receptor de andr\u00f3genos (AR). Los tumores que han escapado de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-05T22:30:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-E0wDiZ5f4ck\/XUggys0dnkI\/AAAAAAAAWIs\/YSLscE1Nt3MrUXtj9Yi9ENoRWaGWgUUmgCLcBGAs\/s1600\/Prostate.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\u00bb\",\"datePublished\":\"2019-08-05T22:30:06+00:00\",\"dateModified\":\"2019-08-05T22:30:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\"},\"wordCount\":526,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Naturopat\u00eda Descriptiva\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=28932#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \\\"La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2019-08-05T22:30:06+00:00\",\"dateModified\":\"2019-08-05T22:30:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=28932\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=28932#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=28932","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\" -","og_description":"Kaipainen, A, Zhang, A, Gil da Costa, RM, et al.&nbsp;Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.&nbsp;The Prostate.&nbsp;2019; 1\u2010 13.&nbsp; FONDO: La testosterona es un impulsor del crecimiento del c\u00e1ncer de pr\u00f3stata (PC) a trav\u00e9s de la activaci\u00f3n mediada por ligando del receptor de andr\u00f3genos (AR). Los tumores que han escapado de [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=28932","article_published_time":"2019-08-05T22:30:06+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-E0wDiZ5f4ck\/XUggys0dnkI\/AAAAAAAAWIs\/YSLscE1Nt3MrUXtj9Yi9ENoRWaGWgUUmgCLcBGAs\/s1600\/Prostate.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\u00bb","datePublished":"2019-08-05T22:30:06+00:00","dateModified":"2019-08-05T22:30:06+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932"},"wordCount":526,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Naturopat\u00eda Descriptiva"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=28932#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932","url":"https:\/\/rina.naturopatiadigital.eu\/?p=28932","name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"La acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2019-08-05T22:30:06+00:00","dateModified":"2019-08-05T22:30:06+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=28932"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=28932#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa acumulaci\u00f3n de testosterona en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata se ve reforzada por la difusi\u00f3n facilitada\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/28932","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28932"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/28932\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28932"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28932"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}