{"id":29065,"date":"2019-08-08T04:30:54","date_gmt":"2019-08-08T02:30:54","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=29065"},"modified":"2019-08-08T04:30:54","modified_gmt":"2019-08-08T02:30:54","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-baicaleina-inhibe-la-progresion-de-las-celulas-de-osteosarcoma-mediante-la-inactivacion-de-la-via-de-senalizacion-de-wnt","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=29065","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa baicale\u00edna inhibe la progresi\u00f3n de las c\u00e9lulas de osteosarcoma mediante la inactivaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de Wnt \/ \u03b2-catenina\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-4l10z1j8pjs\/XUsZ4LL4c5I\/AAAAAAAAWMo\/Oc65NvVpJXYoZSdCYzQfbXL17qome53xQCLcBGAs\/s1600\/Oncotarget.png\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-4l10z1j8pjs\/XUsZ4LL4c5I\/AAAAAAAAWMo\/Oc65NvVpJXYoZSdCYzQfbXL17qome53xQCLcBGAs\/s320\/Oncotarget.png\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Guo Dai, D. Z., Wang, Q., Yang, J., Liu, G., Song, Q., Sun, X., &#8230; &amp; Guo, W. (2017).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5689670\/\">Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt\/\u03b2-catenin signaling pathway<\/a>.&nbsp;<em>Oncotarget<\/em>, 8(49), 86098.<\/p>\n\n\n\n<p>El osteosarcoma es un tipo muy com\u00fan de tumor \u00f3seo maligno en ni\u00f1os y adultos j\u00f3venes y se ha descubierto una activaci\u00f3n aberrante de la v\u00eda de se\u00f1alizaci\u00f3n de Wnt \/ \u03b2-catenina en el osteosarcoma.&nbsp;<\/p>\n\n\n\n<p>Se demostr\u00f3 que la medicina tradicional china baicale\u00edna tiene propiedades antiproliferativas y antimetast\u00e1sicas en el osteosarcoma, pero el mecanismo sigue siendo poco conocido.&nbsp;<\/p>\n\n\n\n<p>En el presente estudio, evaluamos los efectos de la baicale\u00edna sobre el osteosarcoma y detectamos el posible mecanismo molecular.&nbsp;<\/p>\n\n\n\n<p>Encontramos que la baicale\u00edna suprimi\u00f3 significativamente la proliferaci\u00f3n de c\u00e9lulas de osteosarcoma de una manera dependiente de la concentraci\u00f3n y el tiempo. Adem\u00e1s, la baicale\u00edna podr\u00eda inducir apoptosis y detenci\u00f3n del ciclo celular y reducir la motilidad celular. Adem\u00e1s, el nivel de \u03b2-catenina y sus genes diana, incluidos c-myc, cyclinD1, y survivin disminuy\u00f3 significativamente en las c\u00e9lulas de osteosarcoma tratadas con baicale\u00edna, mientras que la expresi\u00f3n ex\u00f3gena de \u03b2-catenina podr\u00eda revertir los efectos antiproliferativos y antimetast\u00e1sicos de la baicale\u00edna.&nbsp;<\/p>\n\n\n\n<p>Posteriormente, establecimos un modelo de tumor de xenoinjerto 143B y descubrimos que el tratamiento con baicale\u00edna inhib\u00eda significativamente el crecimiento tumoral acompa\u00f1ado de la inhibici\u00f3n de la v\u00eda Wnt \/ \u03b2-catenina.&nbsp;<\/p>\n\n\n\n<p>Por lo tanto, estos hallazgos sugieren que la baicale\u00edna puede ser una medicina herbal china potencialmente efectiva para la terap\u00e9utica del osteosarcoma y la v\u00eda de se\u00f1alizaci\u00f3n de Wnt \/ \u03b2-catenina puede servir como un marcador molecular eficiente o un objetivo predictivo para el osteosarcoma.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Guo Dai, D. Z., Wang, Q., Yang, J., Liu, G., Song, Q., Sun, X., &#8230; &amp; Guo, W. (2017).&nbsp;Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt\/\u03b2-catenin signaling pathway.&nbsp;Oncotarget, 8(49), 86098. El osteosarcoma es un tipo muy com\u00fan de tumor \u00f3seo maligno en ni\u00f1os y adultos j\u00f3venes y se ha descubierto una activaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-29065","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La baicale\u00edna inhibe la progresi\u00f3n de las c\u00e9lulas de osteosarcoma mediante la inactivaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de Wnt \/ \u03b2-catenina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=29065\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La baicale\u00edna inhibe la progresi\u00f3n de las c\u00e9lulas de osteosarcoma mediante la inactivaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de Wnt \/ \u03b2-catenina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Guo Dai, D. Z., Wang, Q., Yang, J., Liu, G., Song, Q., Sun, X., &#8230; &amp; Guo, W. (2017).&nbsp;Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt\/\u03b2-catenin signaling pathway.&nbsp;Oncotarget, 8(49), 86098. El osteosarcoma es un tipo muy com\u00fan de tumor \u00f3seo maligno en ni\u00f1os y adultos j\u00f3venes y se ha descubierto una activaci\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=29065\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-08T02:30:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-4l10z1j8pjs\/XUsZ4LL4c5I\/AAAAAAAAWMo\/Oc65NvVpJXYoZSdCYzQfbXL17qome53xQCLcBGAs\/s320\/Oncotarget.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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