{"id":29190,"date":"2019-08-11T01:30:54","date_gmt":"2019-08-10T23:30:54","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=29190"},"modified":"2019-08-11T01:30:54","modified_gmt":"2019-08-10T23:30:54","slug":"area-de-conocimiento-naturopatia-descriptiva-factores-de-riesgo-de-deficiencia-de-vitamina-b12-en-pacientes-que-reciben-metformina","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=29190","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abFactores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-SkNyTkOQpQU\/XU3L7Zhuj9I\/AAAAAAAAWQQ\/Fjdcl3zBYkQhTlLEzJw6mbWkvb7JZQKRACLcBGAs\/s1600\/ArchiveS_internal%2Bmedicine.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-SkNyTkOQpQU\/XU3L7Zhuj9I\/AAAAAAAAWQQ\/Fjdcl3zBYkQhTlLEzJw6mbWkvb7JZQKRACLcBGAs\/s1600\/ArchiveS_internal%2Bmedicine.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Ting, R. Z. W., Szeto, C. C., Chan, M. H. M., Ma, K. K., &amp; Chow, K. M. (2006). <a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/411072\">Risk factors of vitamin B12 deficiency in patients receiving metformin<\/a>. <em>Archives of internal medicine<\/em>, 166(18), 1975-1979.<\/p>\n\n\n\n<p>ANTECEDENTES: La identificaci\u00f3n de los factores de riesgo para la  deficiencia de vitamina B12 relacionada con metformina tiene importantes  implicaciones potenciales con respecto al tratamiento de la diabetes  mellitus.<br><br>METODOS: Realizamos un estudio anidado de casos y  controles a partir de una base de datos en la que la poblaci\u00f3n fuente  consist\u00eda en sujetos que ten\u00edan niveles de vitamina B12 s\u00e9rica y  hemoglobina A 1c controlados en un laboratorio central. Identificamos  155 casos de diabetes mellitus y deficiencia de vitamina B12 secundaria  al tratamiento con metformina. Se seleccionaron otros 310 controles de  la cohorte que no ten\u00edan deficiencia de vitamina B12 mientras tomaban  metformina.<\/p>\n\n\n\n<p>RESULTADOS: Un total de 155 pacientes con deficiencia\n de vitamina B12 relacionada con metformina (media \u00b1 concentraci\u00f3n \ns\u00e9rica de vitamina B 12 SD , 148,6 \u00b1 40,4 pg \/ ml [110 \u00b1 30 pmol \/ L]) \nse compararon con 310 controles pareados (466,1 \u00b1 330,4 pg \/ ml [344 \u00b1 \n244 pmol \/ L]). Despu\u00e9s de ajustar los factores de confusi\u00f3n, \nencontramos una asociaci\u00f3n cl\u00ednicamente importante y estad\u00edsticamente \nsignificativa de la deficiencia de vitamina B12 con la dosis y la \nduraci\u00f3n del uso de metformina. Cada incremento de dosis de metformina \nde 1 g \/ d confiri\u00f3 un cociente de probabilidad de 2,88 (intervalo de \nconfianza del 95%, 2,15-3,87) para desarrollar deficiencia de vitamina \nB12 ( p&lt;0,001). Entre los que usaron metformina durante 3 a\u00f1os o m\u00e1s,\n la raz\u00f3n de probabilidad ajustada fue 2,39 (intervalo de confianza del \n95%, 1,46-3,91) ( P = .001) en comparaci\u00f3n con los que recibieron \nmetformina durante menos de 3 a\u00f1os. Despu\u00e9s de la exclusi\u00f3n de 113 \nsujetos con una concentraci\u00f3n l\u00edmite de vitamina B12 , la dosis de \nmetformina sigui\u00f3 siendo el predictor independiente m\u00e1s fuerte de la \ndeficiencia de vitamina B12 .<\/p>\n\n\n\n<p>CONCLUSIONES: Nuestros resultados \nindican un mayor riesgo de deficiencia de vitamina B12 asociada con la \ndosis actual y la duraci\u00f3n del uso de metformina a pesar del ajuste por \nmuchos posibles factores de confusi\u00f3n. Los factores de riesgo \nidentificados tienen implicaciones para planificar las estrategias de \ndetecci\u00f3n o prevenci\u00f3n en pacientes tratados con metformina.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ting, R. Z. W., Szeto, C. C., Chan, M. H. M., Ma, K. K., &amp; Chow, K. M. (2006). Risk factors of vitamin B12 deficiency in patients receiving metformin. Archives of internal medicine, 166(18), 1975-1979. ANTECEDENTES: La identificaci\u00f3n de los factores de riesgo para la deficiencia de vitamina B12 relacionada con metformina tiene importantes implicaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-29190","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ting, R. Z. W., Szeto, C. C., Chan, M. H. M., Ma, K. K., &amp; Chow, K. M. (2006). Risk factors of vitamin B12 deficiency in patients receiving metformin. Archives of internal medicine, 166(18), 1975-1979. ANTECEDENTES: La identificaci\u00f3n de los factores de riesgo para la deficiencia de vitamina B12 relacionada con metformina tiene importantes implicaciones [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-10T23:30:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-SkNyTkOQpQU\/XU3L7Zhuj9I\/AAAAAAAAWQQ\/Fjdcl3zBYkQhTlLEzJw6mbWkvb7JZQKRACLcBGAs\/s1600\/ArchiveS_internal%2Bmedicine.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abFactores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\u00bb\",\"datePublished\":\"2019-08-10T23:30:54+00:00\",\"dateModified\":\"2019-08-10T23:30:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\"},\"wordCount\":390,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Naturopat\u00eda Descriptiva\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=29190#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \\\"Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2019-08-10T23:30:54+00:00\",\"dateModified\":\"2019-08-10T23:30:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=29190\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=29190#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abFactores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=29190","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\" -","og_description":"Ting, R. Z. W., Szeto, C. C., Chan, M. H. M., Ma, K. K., &amp; Chow, K. M. (2006). Risk factors of vitamin B12 deficiency in patients receiving metformin. Archives of internal medicine, 166(18), 1975-1979. ANTECEDENTES: La identificaci\u00f3n de los factores de riesgo para la deficiencia de vitamina B12 relacionada con metformina tiene importantes implicaciones [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=29190","article_published_time":"2019-08-10T23:30:54+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-SkNyTkOQpQU\/XU3L7Zhuj9I\/AAAAAAAAWQQ\/Fjdcl3zBYkQhTlLEzJw6mbWkvb7JZQKRACLcBGAs\/s1600\/ArchiveS_internal%2Bmedicine.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abFactores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\u00bb","datePublished":"2019-08-10T23:30:54+00:00","dateModified":"2019-08-10T23:30:54+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190"},"wordCount":390,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Naturopat\u00eda Descriptiva"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=29190#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190","url":"https:\/\/rina.naturopatiadigital.eu\/?p=29190","name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \"Factores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2019-08-10T23:30:54+00:00","dateModified":"2019-08-10T23:30:54+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=29190"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=29190#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abFactores de riesgo de deficiencia de vitamina B12 en pacientes que reciben metformina\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/29190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29190"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/29190\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}