{"id":29193,"date":"2019-08-11T02:30:51","date_gmt":"2019-08-11T00:30:51","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=29193"},"modified":"2019-08-11T02:30:51","modified_gmt":"2019-08-11T00:30:51","slug":"area-de-conocimiento-naturopatia-descriptiva-efectos-del-tratamiento-a-corto-plazo-con-metformina-en-las-concentraciones-sericas-de-homocisteina-acido-folico-y-vitamina-b12-en-la-diabetes-mellitu","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=29193","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEfectos del tratamiento a corto plazo con metformina en las concentraciones s\u00e9ricas de homociste\u00edna, \u00e1cido f\u00f3lico y vitamina B12 en la diabetes mellitus tipo 2: un ensayo aleatorizado, controlado con placebo\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/--RUnaZUdNKI\/XU3OYgWaohI\/AAAAAAAAWQY\/cnnLAfixtlArzwbEDvyjxdeD56mgUv0rgCLcBGAs\/s1600\/Journal_internal%2Bmedicine.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/--RUnaZUdNKI\/XU3OYgWaohI\/AAAAAAAAWQY\/cnnLAfixtlArzwbEDvyjxdeD56mgUv0rgCLcBGAs\/s1600\/Journal_internal%2Bmedicine.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Wulffele, M. G., Kooy, A., Lehert, P., Bets, D., Ogterop, J. C., Borger Van Der Burg, B., &#8230; &amp; Stehouwer, C. D. A. (2003). <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1046\/j.1365-2796.2003.01213.x\">Effects  of short\u2010term treatment with metformin on serum concentrations of  homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a  randomized, placebo\u2010controlled trial<\/a>. <em>Journal of internal medicine<\/em>, 254(5), 455-463.<\/p>\n\n\n\n<p> OBJETIVO: La metformina es una opci\u00f3n de tratamiento clave en la  diabetes tipo 2. Sin embargo, la metformina puede disminuir los niveles  de vitamina B12 y aumentar los niveles de homo-ciste\u00edna, un factor de  riesgo cardiovascular. Investigamos si 16 semanas de tratamiento con  metformina afecta las concentraciones s\u00e9ricas de homo-ciste\u00edna, \u00e1cido  f\u00f3lico y vitamina B12 en sujetos con diabetes tipo 2 tratados con  insulina.<br><br>DISE\u00d1O: Ensayo aleatorio controlado con placebo. Mediciones: al inicio y 16 semanas despu\u00e9s.<\/p>\n\n\n\n<p>AJUSTE: Este ensayo se realiz\u00f3 en las cl\u00ednicas ambulatorias de tres hospitales generales en los Pa\u00edses Bajos.<br><br>PARTICIPANTES:\n Se contact\u00f3 a un total de 745 pacientes con diabetes tipo 2, tratados \ncon insulina y no conocidos con una contraindicaci\u00f3n para el uso de \nmetformina; 390 dieron su consentimiento informado y entraron al \nestudio. Treinta y siete sujetos abandonaron (12 placebo y 25 usuarios \nde metformina).<\/p>\n\n\n\n<p>INTERVENCION: Adici\u00f3n de metformina o placebo a la terapia con insulina.<br><br>PARAMETROS\n PRIMARIOS DE RESULTADOS: Homociste\u00edna s\u00e9rica, \u00e1cido f\u00f3lico, vitamina \nB12, \u00edndices de control gluc\u00e9mico y peso corporal.<\/p>\n\n\n\n<p>RESULTADOS: \nEntre los que completaron 16 semanas de tratamiento, el uso de \nmetformina, en comparaci\u00f3n con el placebo, se asoci\u00f3 con un aumento en \nla homociste\u00edna del 4% (0.2 a 8; P \u2003= 0.039) y con disminuciones en el \nfolato [\u22127% (\u22121.4 a &#8211; 13); P \u2003= 0.024] y vitamina B12 [\u221214% (\u22124.2 a \n\u221224); P \u2003&lt;0,0001]. Adem\u00e1s, el aumento de la homociste\u00edna podr\u00eda \nexplicarse por la disminuci\u00f3n del \u00e1cido f\u00f3lico y la vitamina B12.<\/p>\n\n\n\n<p>CONCLUSION:\n En pacientes con diabetes tipo 2, 16 semanas de tratamiento con \nmetformina reducen los niveles de \u00e1cido f\u00f3lico y vitamina B12, lo que \nresulta en un aumento modesto de la homociste\u00edna. La importancia cl\u00ednica\n de estos hallazgos queda por investigar.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wulffele, M. G., Kooy, A., Lehert, P., Bets, D., Ogterop, J. C., Borger Van Der Burg, B., &#8230; &amp; Stehouwer, C. D. A. (2003). Effects of short\u2010term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo\u2010controlled trial. Journal of internal medicine, 254(5), 455-463. OBJETIVO: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-29193","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Efectos del tratamiento a corto plazo con metformina en las concentraciones s\u00e9ricas de homociste\u00edna, \u00e1cido f\u00f3lico y vitamina B12 en la diabetes mellitus tipo 2: un ensayo aleatorizado, controlado con placebo&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=29193\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Efectos del tratamiento a corto plazo con metformina en las concentraciones s\u00e9ricas de homociste\u00edna, \u00e1cido f\u00f3lico y vitamina B12 en la diabetes mellitus tipo 2: un ensayo aleatorizado, controlado con placebo&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wulffele, M. G., Kooy, A., Lehert, P., Bets, D., Ogterop, J. C., Borger Van Der Burg, B., &#8230; &amp; Stehouwer, C. D. A. (2003). Effects of short\u2010term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo\u2010controlled trial. Journal of internal medicine, 254(5), 455-463. 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