{"id":29372,"date":"2019-08-14T01:30:18","date_gmt":"2019-08-13T23:30:18","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=29372"},"modified":"2019-08-14T01:30:18","modified_gmt":"2019-08-13T23:30:18","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-objetivos-moleculares-y-potencial-anticancerigeno-del-indol-3-carbinol-y-sus-derivados","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=29372","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abObjetivos moleculares y potencial anticancer\u00edgeno del indol-3-carbinol y sus derivados\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-XV9GD9Jl8Rc\/XVJ3wUE14pI\/AAAAAAAAWVo\/PhDeZiUFdYU7NTSopjq45n4NWlLqorCNwCLcBGAs\/s1600\/Cell_Cycle.JPG\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-XV9GD9Jl8Rc\/XVJ3wUE14pI\/AAAAAAAAWVo\/PhDeZiUFdYU7NTSopjq45n4NWlLqorCNwCLcBGAs\/s1600\/Cell_Cycle.JPG\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Aggarwal, B. B., &amp; Ichikawa, H. (2005).&nbsp;<a href=\"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/cc.4.9.1993\">Molecular targets and anticancer potential of indole-3-carbinol and its derivatives<\/a>.&nbsp;<em>Cell cycle<\/em>, 4(9), 1201-1215.<\/p>\n\n\n\n<p>El indol-3-carbinol (I3C) es producido por miembros de la familia Cruciferae, y particularmente miembros del g\u00e9nero Brassica (p. Ej., Repollo, r\u00e1banos, coliflor, br\u00f3coli, coles de Bruselas y daikon).&nbsp;<\/p>\n\n\n\n<p>En condiciones \u00e1cidas, el 13C se convierte en una serie de productos oligom\u00e9ricos (entre los cuales el 3,3&#8242;-diindolilmetano es un componente principal) que se cree que es responsable de sus efectos biol\u00f3gicos in vivo.&nbsp;<\/p>\n\n\n\n<p>In vitro, se ha demostrado que 13C suprime la proliferaci\u00f3n de varias c\u00e9lulas tumorales, incluyendo c\u00e1ncer de mama, c\u00e1ncer de pr\u00f3stata, c\u00e1ncer de endometrio, c\u00e1ncer de colon y c\u00e9lulas leuc\u00e9micas; induce la detenci\u00f3n de G1 \/ S del ciclo celular e induce la apoptosis.&nbsp;<\/p>\n\n\n\n<p>La detenci\u00f3n del ciclo celular implica la regulaci\u00f3n negativa de ciclina D1, ciclina E, quinasa dependiente de ciclina (CDK) 2, CDK4 y CDK6 y la regulaci\u00f3n positiva de p15, p21 y p27. La apoptosis por I3C implica productos de genes antiapopt\u00f3ticos de regulaci\u00f3n negativa, que incluyen Bcl-2, Bcl-xL, survivina, prote\u00edna inhibidora de la apoptosis (IAP), IAP unida al cromosoma X (XIAP) e interleucina similar a la prote\u00edna del dominio de la muerte asociada a Fas Prote\u00edna inhibidora de la enzima convertidora 1-beta (FLIP); regulaci\u00f3n positiva de la prote\u00edna proapopt\u00f3tica Bax; liberaci\u00f3n de citocromo C micocondrial; y activaci\u00f3n de caspase-9 y caspase-3.&nbsp;<\/p>\n\n\n\n<p>Este agente inhibe la activaci\u00f3n de varios factores de transcripci\u00f3n, incluidos el factor nuclear kappaB, SP1, el receptor de estr\u00f3genos, el receptor de andr\u00f3genos y el factor 2 relacionado con el factor nuclear E2 (Nrf2). Este indol potencia los efectos del ligando inductor de apoptosis relacionado con el factor de necrosis tumoral (TRAIL) a trav\u00e9s de la inducci\u00f3n de receptores de muerte y sinergias con agentes quimioterap\u00e9uticos a trav\u00e9s de la regulaci\u00f3n negativa de la glicoprote\u00edna P (P-gp).&nbsp;<\/p>\n\n\n\n<p>En vivo, se descubri\u00f3 que el I3C es un potente agente quimiopreventivo para los c\u00e1nceres dependientes de hormonas, como el c\u00e1ncer de mama y de cuello uterino. Estos efectos est\u00e1n mediados por su capacidad para inducir apoptosis, inhibir la formaci\u00f3n de aductos de ADN-carcin\u00f3geno y suprimir la producci\u00f3n de radicales libres, estimular la 2-hidroxilaci\u00f3n de estradiol, inhibir la invasi\u00f3n y la angiog\u00e9nesis.&nbsp;<\/p>\n\n\n\n<p>Numerosos estudios han indicado que I3C tambi\u00e9n tiene una fuerte actividad hepatoprotectora contra diversos carcin\u00f3genos. Los ensayos cl\u00ednicos iniciales en mujeres han demostrado que I3C es un agente prometedor contra los c\u00e1nceres de mama y cuello uterino. inhibir la invasi\u00f3n y la angiog\u00e9nesis.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aggarwal, B. B., &amp; Ichikawa, H. (2005).&nbsp;Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.&nbsp;Cell cycle, 4(9), 1201-1215. El indol-3-carbinol (I3C) es producido por miembros de la familia Cruciferae, y particularmente miembros del g\u00e9nero Brassica (p. Ej., Repollo, r\u00e1banos, coliflor, br\u00f3coli, coles de Bruselas y daikon).&nbsp; En condiciones \u00e1cidas, el 13C se convierte en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-29372","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Objetivos moleculares y potencial anticancer\u00edgeno del indol-3-carbinol y sus derivados&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=29372\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Objetivos moleculares y potencial anticancer\u00edgeno del indol-3-carbinol y sus derivados&quot; -\" \/>\n<meta property=\"og:description\" content=\"Aggarwal, B. B., &amp; Ichikawa, H. (2005).&nbsp;Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.&nbsp;Cell cycle, 4(9), 1201-1215. El indol-3-carbinol (I3C) es producido por miembros de la familia Cruciferae, y particularmente miembros del g\u00e9nero Brassica (p. Ej., Repollo, r\u00e1banos, coliflor, br\u00f3coli, coles de Bruselas y daikon).&nbsp; En condiciones \u00e1cidas, el 13C se convierte en [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=29372\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-13T23:30:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-XV9GD9Jl8Rc\/XVJ3wUE14pI\/AAAAAAAAWVo\/PhDeZiUFdYU7NTSopjq45n4NWlLqorCNwCLcBGAs\/s1600\/Cell_Cycle.JPG\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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