{"id":29384,"date":"2019-08-14T05:30:57","date_gmt":"2019-08-14T03:30:57","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=29384"},"modified":"2019-08-14T05:30:57","modified_gmt":"2019-08-14T03:30:57","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-inhibicion-del-crecimiento-tumoral-por-el-indol-3-carbinol-en-la-dieta-en-un-modelo-de-xenoinjerto-de-cancer-de-prostata-pue","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=29384","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa inhibici\u00f3n del crecimiento tumoral por el indol-3-carbinol en la dieta en un modelo de xenoinjerto de c\u00e1ncer de pr\u00f3stata puede asociarse con interacciones microbianas intestinales interrumpidas\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-py1OEHeB2Pk\/XVKbgOPM0EI\/AAAAAAAAWWI\/MdKVOIGdnLk_dXars5Ne8jk75Hpgm4qzwCLcBGAs\/s1600\/Nutrients2.JPG\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-py1OEHeB2Pk\/XVKbgOPM0EI\/AAAAAAAAWWI\/MdKVOIGdnLk_dXars5Ne8jk75Hpgm4qzwCLcBGAs\/s320\/Nutrients2.JPG\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Wu, Y., Li, R. W., Huang, H., Fletcher, A., Yu, L., Pham, Q., &#8230; &amp; Wang, T. T. (2019).&nbsp;<a href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/2\/467\/htm\">Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions<\/a>.&nbsp;<em>Nutrients<\/em>, 11(2), 467. <\/p>\n\n\n\n<p>FONDO: La evidencia acumulada sugiere que el compuesto derivado de vegetales cruc\u00edferos indol-3-carbinol (I3C) puede proteger contra el c\u00e1ncer de pr\u00f3stata, pero los mecanismos precisos subyacentes a su acci\u00f3n siguen sin estar claros.&nbsp;<\/p>\n\n\n\n<p>OBJETIVO: Este estudio tuvo como objetivo verificar la hip\u00f3tesis de que el efecto beneficioso del I3C en la dieta puede deberse a su efecto modulador en el microbioma intestinal de los ratones.&nbsp;<\/p>\n\n\n\n<p>METODO \/ DISE\u00d1O: Los ratones at\u00edmicos desnudos (5\u207b7 semanas de edad, machos, Balb c \/ c nu \/ nu) con xenoinjertos tumorales establecidos se alimentaron con una dieta basal (AIN-93) con o sin 1 \u00b5moles de I3C \/ g durante 9 semanas.&nbsp;<\/p>\n\n\n\n<p>MEDIDAS DE RESULTADOS: Los efectos de I3C en la dieta sobre la composici\u00f3n microbiana intestinal y las interacciones de especies microbianas se examinaron luego mediante an\u00e1lisis de la secuencia de genes basados \u200b\u200ben el gen 16s rRNA y el an\u00e1lisis de redes de coincidencia.&nbsp;<\/p>\n\n\n\n<p>RESULTADOS: La suplementaci\u00f3n con I3C inhibi\u00f3 significativamente el crecimiento tumoral ( p&lt;0.0001) y alter\u00f3 la estructura del microbioma intestinal. La abundancia del filo Deferribacteres, m\u00e1s espec\u00edficamente, Mucispirillum schaedleri , aument\u00f3 significativamente por la dieta I3C. Adem\u00e1s, el consumo de I3C tambi\u00e9n cambi\u00f3 los patrones de co-ocurrencia microbiana intestinal. Uno de los m\u00f3dulos de red en el grupo de control, que consta de siete bacterias en la familia S-27, se correlacion\u00f3 positivamente con el tama\u00f1o del tumor ( p &lt;0,009). Adem\u00e1s, la dieta I3C interrumpi\u00f3 las interacciones microbianas y alter\u00f3 esta asociaci\u00f3n entre la red microbiana espec\u00edfica y el desarrollo tumoral.&nbsp;<\/p>\n\n\n\n<p>CONCLUSION: Nuestros resultados revelaron relaciones complejas entre la ingesti\u00f3n de I3C, la microbiota intestinal y el desarrollo de tumores de pr\u00f3stata y pueden proporcionar una nueva visi\u00f3n del mecanismo del efecto quimiopreventivo de I3C en la dieta sobre el c\u00e1ncer de pr\u00f3stata.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wu, Y., Li, R. W., Huang, H., Fletcher, A., Yu, L., Pham, Q., &#8230; &amp; Wang, T. T. (2019).&nbsp;Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions.&nbsp;Nutrients, 11(2), 467. FONDO: La evidencia acumulada sugiere que el compuesto derivado de vegetales cruc\u00edferos indol-3-carbinol (I3C) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-29384","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La inhibici\u00f3n del crecimiento tumoral por el indol-3-carbinol en la dieta en un modelo de xenoinjerto de c\u00e1ncer de pr\u00f3stata puede asociarse con interacciones microbianas intestinales interrumpidas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=29384\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La inhibici\u00f3n del crecimiento tumoral por el indol-3-carbinol en la dieta en un modelo de xenoinjerto de c\u00e1ncer de pr\u00f3stata puede asociarse con interacciones microbianas intestinales interrumpidas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wu, Y., Li, R. W., Huang, H., Fletcher, A., Yu, L., Pham, Q., &#8230; &amp; Wang, T. T. (2019).&nbsp;Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions.&nbsp;Nutrients, 11(2), 467. 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