{"id":30022,"date":"2019-08-25T00:30:51","date_gmt":"2019-08-24T22:30:51","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=30022"},"modified":"2019-08-25T00:30:51","modified_gmt":"2019-08-24T22:30:51","slug":"area-de-conocimiento-naturopatia-descriptiva-autofagia-mediada-por-chaperona-en-el-envejecimiento-y-la-enfermedad","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=30022","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abAutofagia mediada por chaperona en el envejecimiento y la enfermedad\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-BsfojzYqfeY\/XWFWjE1_SLI\/AAAAAAAAWmY\/qLbU4v2xCmQ_KqKSa2P8worSmvSYmxSUwCLcBGAs\/s1600\/Current_topics%2Bin%2Bdevelopmental%2Bbiology.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-BsfojzYqfeY\/XWFWjE1_SLI\/AAAAAAAAWmY\/qLbU4v2xCmQ_KqKSa2P8worSmvSYmxSUwCLcBGAs\/s1600\/Current_topics%2Bin%2Bdevelopmental%2Bbiology.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Massey, A. C., Zhang, C., &amp; Cuervo, A. M. (2006).&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0070215305730076\">Chaperone\u2010mediated autophagy in aging and disease<\/a>.&nbsp;<em>Current topics in developmental biology<\/em>, 73, 205-235.&nbsp;<\/p>\n\n\n\n<p>Diferentes mecanismos se dirigen a los componentes intracelulares para su degradaci\u00f3n en los lisosomas a trav\u00e9s de lo que se conoce como autofagia.&nbsp;<br>En los mam\u00edferos, se han descrito tres formas principales de autofagia: macroautofagia, microautofagia y autofagia mediada por chaperonas (CMA). CMA es la \u00fanica v\u00eda autof\u00e1gica que permite la degradaci\u00f3n selectiva de prote\u00ednas solubles en lisosomas.&nbsp;<\/p>\n\n\n\n<p>A diferencia de otras formas de autofagia en mam\u00edferos, la CMA no requiere la formaci\u00f3n de ves\u00edculas o grandes cambios en la membrana lisos\u00f3mica. En cambio, las prote\u00ednas del sustrato cruzan directamente la membrana lisos\u00f3mica para alcanzar la luz, donde se degradan r\u00e1pidamente.&nbsp;<\/p>\n\n\n\n<p>Las prote\u00ednas del sustrato est\u00e1n dirigidas a la membrana lisos\u00f3mica mediante el reconocimiento de un motivo de direccionamiento (un motivo similar a KFERQ), mediante un complejo de chaperona, que consiste en hsc70 y sus cochaperonas, en el citoplasma.&nbsp;<\/p>\n\n\n\n<p>Una vez en la membrana lisosomal, la prote\u00edna interact\u00faa con un receptor lisosomal para esta v\u00eda, prote\u00edna de membrana asociada a lisosomatipo 2A (LAMP-2A), y se transloca a trav\u00e9s de la membrana hacia la luz lisos\u00f3mica asistida por un chaper\u00f3n residente de lisosomas. <\/p>\n\n\n\n<p>Estas dos caracter\u00edsticas -la selectividad y la translocaci\u00f3n directa del sustrato- determinan el rol particular de CMA en diferentes condiciones fisiol\u00f3gicas y patol\u00f3gicas.&nbsp;<\/p>\n\n\n\n<p>En este cap\u00edtulo, cubrimos los hallazgos actuales sobre los mecanismos moleculares para CMA y la posible relevancia fisiopatol\u00f3gica de esta degradaci\u00f3n lisos\u00f3mica selectiva. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Massey, A. C., Zhang, C., &amp; Cuervo, A. M. (2006).&nbsp;Chaperone\u2010mediated autophagy in aging and disease.&nbsp;Current topics in developmental biology, 73, 205-235.&nbsp; Diferentes mecanismos se dirigen a los componentes intracelulares para su degradaci\u00f3n en los lisosomas a trav\u00e9s de lo que se conoce como autofagia.&nbsp;En los mam\u00edferos, se han descrito tres formas principales de autofagia: macroautofagia, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-30022","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Autofagia mediada por chaperona en el envejecimiento y la enfermedad&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=30022\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Autofagia mediada por chaperona en el envejecimiento y la enfermedad&quot; -\" \/>\n<meta property=\"og:description\" content=\"Massey, A. C., Zhang, C., &amp; Cuervo, A. M. (2006).&nbsp;Chaperone\u2010mediated autophagy in aging and disease.&nbsp;Current topics in developmental biology, 73, 205-235.&nbsp; Diferentes mecanismos se dirigen a los componentes intracelulares para su degradaci\u00f3n en los lisosomas a trav\u00e9s de lo que se conoce como autofagia.&nbsp;En los mam\u00edferos, se han descrito tres formas principales de autofagia: macroautofagia, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=30022\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-24T22:30:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-BsfojzYqfeY\/XWFWjE1_SLI\/AAAAAAAAWmY\/qLbU4v2xCmQ_KqKSa2P8worSmvSYmxSUwCLcBGAs\/s1600\/Current_topics%2Bin%2Bdevelopmental%2Bbiology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" 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