{"id":30050,"date":"2019-08-26T02:30:12","date_gmt":"2019-08-26T00:30:12","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=30050"},"modified":"2019-08-26T02:30:12","modified_gmt":"2019-08-26T00:30:12","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-isoliquiritigenina-induce-la-apoptosis-y-la-autofagia-e-inhibe-el-crecimiento-del-cancer-de-endometrio-en-ratones","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=30050","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: La isoliquiritigenina induce la apoptosis y la autofagia e inhibe el crecimiento del c\u00e1ncer de endometrio en ratones\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-69n0NGqaF-4\/XWFvdSBxLII\/AAAAAAAAWno\/-zntMncrenMqJLqZsDLwxqn9Q3venR-TQCLcBGAs\/s1600\/Oncotarget2.png\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-69n0NGqaF-4\/XWFvdSBxLII\/AAAAAAAAWno\/-zntMncrenMqJLqZsDLwxqn9Q3venR-TQCLcBGAs\/s320\/Oncotarget2.png\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Wu, C. H., Chen, H. Y., Wang, C. W., Shieh, T. M., Huang, T. C., Lin, L. C., &#8230; &amp; Hsia, S. M. (2016).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5341989\/\">Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.&nbsp;<\/a><em>Oncotarget<\/em>, 7(45), 73432.<\/p>\n\n\n\n<p>El c\u00e1ncer de endometrio es el c\u00e1ncer m\u00e1s com\u00fan en las mujeres,  generalmente con aparici\u00f3n despu\u00e9s de la menopausia. La isoliquiritigenina (ISL), un flavonoide de regaliz, mostr\u00f3 previamente efectos antioxidantes, antiinflamatorios y de supresi\u00f3n tumoral.&nbsp; <\/p>\n\n\n\n<p>OBJETIVO: En este estudio, investigamos el efecto antitumoral de ISL sobre el c\u00e1ncer de endometrio humano tanto in vitro como in vivo.&nbsp;<\/p>\n\n\n\n<p>M\u00c9TODO: Utilizamos c\u00e9lulas del estroma endometrial humano inmortalizado por telomerasa (T-HESC) y l\u00edneas celulares de c\u00e1ncer de endometrio humano (c\u00e9lulas Ishikawa, HEC-1A y RL95-2) como objetivos. Se examinaron los efectos de ISL sobre la proliferaci\u00f3n celular, la regulaci\u00f3n del ciclo celular y la apoptosis o la expresi\u00f3n de prote\u00ednas relacionadas con la autofagia. Adem\u00e1s, realizamos experimentos in vivo para confirmar los efectos inhibitorios de ISL en las c\u00e9lulas cancerosas.&nbsp;<\/p>\n\n\n\n<p>RESULTADOS: El ISL inhibi\u00f3 significativamente la viabilidad de las c\u00e9lulas cancerosas de una manera dependiente de la dosis y el tiempo, pero con poca toxicidad en las c\u00e9lulas normales. Adem\u00e1s, el an\u00e1lisis de citometr\u00eda de flujo indic\u00f3 que ISL indujo la detenci\u00f3n de la fase sub-G1 o G2 \/ M. El tratamiento con ISL activ\u00f3 la v\u00eda de se\u00f1alizaci\u00f3n de la quinasa regulada por se\u00f1al extracelular para mejorar la expresi\u00f3n proteica de caspasa-7 \/ LC3BII asociada con apoptosis \/ autofagia. Adem\u00e1s, ISL suprimi\u00f3 el crecimiento tumoral de xenoinjerto in vivo.&nbsp;<\/p>\n\n\n\n<p>CONCLUSI\u00d3N: Tomados en conjunto, estos hallazgos sugieren que el ISL puede inducir apoptosis, autofagia e inhibici\u00f3n del crecimiento celular, lo que indica su potencial como agente terap\u00e9utico para el c\u00e1ncer de endometrio humano.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wu, C. H., Chen, H. Y., Wang, C. W., Shieh, T. M., Huang, T. C., Lin, L. C., &#8230; &amp; Hsia, S. M. (2016).&nbsp;Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.&nbsp;Oncotarget, 7(45), 73432. El c\u00e1ncer de endometrio es el c\u00e1ncer m\u00e1s com\u00fan en las mujeres, generalmente con aparici\u00f3n despu\u00e9s de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-30050","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: La isoliquiritigenina induce la apoptosis y la autofagia e inhibe el crecimiento del c\u00e1ncer de endometrio en ratones&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=30050\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: La isoliquiritigenina induce la apoptosis y la autofagia e inhibe el crecimiento del c\u00e1ncer de endometrio en ratones&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wu, C. H., Chen, H. Y., Wang, C. W., Shieh, T. M., Huang, T. C., Lin, L. C., &#8230; &amp; Hsia, S. M. (2016).&nbsp;Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.&nbsp;Oncotarget, 7(45), 73432. El c\u00e1ncer de endometrio es el c\u00e1ncer m\u00e1s com\u00fan en las mujeres, generalmente con aparici\u00f3n despu\u00e9s de la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=30050\" \/>\n<meta property=\"article:published_time\" content=\"2019-08-26T00:30:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-69n0NGqaF-4\/XWFvdSBxLII\/AAAAAAAAWno\/-zntMncrenMqJLqZsDLwxqn9Q3venR-TQCLcBGAs\/s320\/Oncotarget2.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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