{"id":30491,"date":"2019-09-02T03:30:37","date_gmt":"2019-09-02T01:30:37","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=30491"},"modified":"2019-09-02T03:30:37","modified_gmt":"2019-09-02T01:30:37","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-limonina-citrica-y-su-glucosido-inhiben-la-proliferacion-celular-de-adenocarcinoma-de-colon-a-traves-de-la-apoptosis","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=30491","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa limonina c\u00edtrica y su gluc\u00f3sido inhiben la proliferaci\u00f3n celular de adenocarcinoma de colon a trav\u00e9s de la apoptosis\u00bb"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><a href=\"https:\/\/1.bp.blogspot.com\/-TEqkAOKtwPw\/XWqZvwnhxMI\/AAAAAAAAWys\/NBdYZYx5PQkcO8M4Pz_2Xg4jGcytDZkiACLcBGAs\/s1600\/Journal_Agricultural%2Band%2BFood%2BChemistry2.jpg\"><img decoding=\"async\" src=\"https:\/\/1.bp.blogspot.com\/-TEqkAOKtwPw\/XWqZvwnhxMI\/AAAAAAAAWys\/NBdYZYx5PQkcO8M4Pz_2Xg4jGcytDZkiACLcBGAs\/s320\/Journal_Agricultural%2Band%2BFood%2BChemistry2.jpg\" alt=\"\"\/><\/a><\/figure><\/div>\n\n\n\n<p>Chidambara Murthy, K. N., Jayaprakasha, G. K., Kumar, V., Rathore, K. S., &amp; Patil, B. S. (2011).&nbsp;<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf104498p\">Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis<\/a>.&nbsp;<em>Journal of agricultural and food chemistry<\/em>, 59(6), 2314-2323.<\/p>\n\n\n\n<p>El estudio actual fue un intento de dilucidar el mecanismo de inhibici\u00f3n de la proliferaci\u00f3n celular del c\u00e1ncer de colon humano por la limonina y el gluc\u00f3sido de limonina (LG) aislado de semillas de Citrus reticulata.&nbsp;<\/p>\n\n\n\n<p>Las estructuras de los compuestos purificados se confirmaron mediante RMN y se cuantificaron usando HPLC. Estos compuestos de m\u00e1s del 95% de pureza se sometieron a un ensayo de inhibici\u00f3n de la proliferaci\u00f3n utilizando c\u00e9lulas de adenocarcinoma de colon humano (SW480). El IC 50 se observ\u00f3 valor de 54.74 y 37.39 M durante limonina y LG, respectivamente a las 72 h.&nbsp;<\/p>\n\n\n\n<p>Tras la confirmaci\u00f3n de la inhibici\u00f3n de la proliferaci\u00f3n, el patr\u00f3n de fragmentaci\u00f3n del ADN y la activaci\u00f3n de la caspasa-3 de las c\u00e9lulas tratadas con limonoides sugieren la implicaci\u00f3n de la apoptosis. Adem\u00e1s, reducci\u00f3n en la relaci\u00f3n de transcripci\u00f3n de bcl2 \/ baxy la inducci\u00f3n de la liberaci\u00f3n de citocromo c de las mitocondrias al citosol con tratamiento de limonoides confirman la activaci\u00f3n de la v\u00eda de apoptosis intr\u00ednseca.&nbsp;<\/p>\n\n\n\n<p>La actividad de Bax y Bcl2 se confirm\u00f3 mediante el an\u00e1lisis del potencial de membrana mitocondrial y el calcio intracelular en las c\u00e9lulas tratadas con limonina y LG; El contenido neto de caspasa-8 no fue afectado por limonoides.&nbsp;<\/p>\n\n\n\n<p>Los resultados del estudio actual proporcionan evidencia convincente sobre la inducci\u00f3n de apoptosis intr\u00ednseca mediada por mitocondrias por parte de limonina y LG en c\u00e9lulas SW480 cultivadas por primera vez.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chidambara Murthy, K. N., Jayaprakasha, G. K., Kumar, V., Rathore, K. S., &amp; Patil, B. S. (2011).&nbsp;Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.&nbsp;Journal of agricultural and food chemistry, 59(6), 2314-2323. El estudio actual fue un intento de dilucidar el mecanismo de inhibici\u00f3n de la proliferaci\u00f3n celular del c\u00e1ncer de colon [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-30491","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La limonina c\u00edtrica y su gluc\u00f3sido inhiben la proliferaci\u00f3n celular de adenocarcinoma de colon a trav\u00e9s de la apoptosis&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=30491\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La limonina c\u00edtrica y su gluc\u00f3sido inhiben la proliferaci\u00f3n celular de adenocarcinoma de colon a trav\u00e9s de la apoptosis&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chidambara Murthy, K. N., Jayaprakasha, G. K., Kumar, V., Rathore, K. S., &amp; Patil, B. S. (2011).&nbsp;Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.&nbsp;Journal of agricultural and food chemistry, 59(6), 2314-2323. El estudio actual fue un intento de dilucidar el mecanismo de inhibici\u00f3n de la proliferaci\u00f3n celular del c\u00e1ncer de colon [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=30491\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-02T01:30:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-TEqkAOKtwPw\/XWqZvwnhxMI\/AAAAAAAAWys\/NBdYZYx5PQkcO8M4Pz_2Xg4jGcytDZkiACLcBGAs\/s320\/Journal_Agricultural%2Band%2BFood%2BChemistry2.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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N., Jayaprakasha, G. K., Kumar, V., Rathore, K. S., &amp; Patil, B. S. (2011).&nbsp;Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.&nbsp;Journal of agricultural and food chemistry, 59(6), 2314-2323. 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