{"id":30928,"date":"2019-09-12T06:30:05","date_gmt":"2019-09-12T04:30:05","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=30928"},"modified":"2019-09-12T06:30:05","modified_gmt":"2019-09-12T04:30:05","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-potencial-antiproliferativo-de-la-curcumina-en-las-celulas-de-cancer-de-prostata-dependiente-de-androgenos-se-produce-a-trav","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=30928","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl potencial antiproliferativo de la curcumina en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata dependiente de andr\u00f3genos se produce a trav\u00e9s de la modulaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Dj7isxor5YU\/XXlr8AUsB_I\/AAAAAAAAW_o\/pbjWENV8fG8p7HgmdY3Nvr0PDiWujo47wCLcBGAsYHQ\/s1600\/International_journal%2Bof%2Boncology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Dj7isxor5YU\/XXlr8AUsB_I\/AAAAAAAAW_o\/pbjWENV8fG8p7HgmdY3Nvr0PDiWujo47wCLcBGAsYHQ\/s1600\/International_journal%2Bof%2Boncology.jpg\" border=\"0\" data-original-width=\"191\" data-original-height=\"264\" \/><\/a>Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., &amp; Diederich, M. (2011). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21240460\">Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway<\/a>. <i>International journal of oncology,<\/i> 38(3), 603-611.<\/p>\n<p>La activaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless (Wnt) \/ \u00df-catenina contribuye a la tumorig\u00e9nesis y met\u00e1stasis de pr\u00f3stata. Dependiendo de la etapa de desarrollo del c\u00e1ncer de pr\u00f3stata, las terapias farmacol\u00f3gicas actuales tienen una eficacia limitada, por lo que la prevenci\u00f3n con compuestos naturales aparece como una estrategia atractiva, especialmente debido al lento y progresivo desarrollo del c\u00e1ncer de pr\u00f3stata.\u00a0<\/p>\n<p>Aqu\u00ed informamos que el agente quimiopreventivo curcumina del rizoma de Curcuma longa pudo afectar la proliferaci\u00f3n celular del c\u00e1ncer de pr\u00f3stata dependiente de andr\u00f3genos mediante la inducci\u00f3n de la detenci\u00f3n del ciclo celular en G2 y la modulaci\u00f3n de la se\u00f1alizaci\u00f3n de Wnt. La curcumina disminuye el nivel de Tcf-4, las prote\u00ednas CBP y p300 implicadas en el complejo transcripcional Wnt que conduce a la disminuci\u00f3n de la actividad transcripcional de \u00df-catenina \/ Tcf-4 y de la expresi\u00f3n de genes diana de \u00df-catenina (ciclina D1 y c-myc).\u00a0<\/p>\n<p>La inducci\u00f3n de muerte celular posterior est\u00e1 vinculada a la autofagia. Curiosamente, en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos, la curcumina no afecta la actividad transcripcional de Wnt \/ \u00df-catenina.\u00a0<\/p>\n<p>En conjunto, nuestros resultados sugieren que la curcumina es un agente quimiopreventivo interesante para el c\u00e1ncer de pr\u00f3stata en etapa temprana.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., &amp; Diederich, M. (2011). Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. International journal of oncology, 38(3), 603-611. La activaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless (Wnt) \/ \u00df-catenina contribuye a la tumorig\u00e9nesis y met\u00e1stasis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-30928","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El potencial antiproliferativo de la curcumina en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata dependiente de andr\u00f3genos se produce a trav\u00e9s de la modulaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=30928\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El potencial antiproliferativo de la curcumina en las c\u00e9lulas de c\u00e1ncer de pr\u00f3stata dependiente de andr\u00f3genos se produce a trav\u00e9s de la modulaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless&quot; -\" \/>\n<meta property=\"og:description\" content=\"Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., &amp; Diederich, M. (2011). Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. International journal of oncology, 38(3), 603-611. La activaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Wingless (Wnt) \/ \u00df-catenina contribuye a la tumorig\u00e9nesis y met\u00e1stasis [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=30928\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-12T04:30:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-Dj7isxor5YU\/XXlr8AUsB_I\/AAAAAAAAW_o\/pbjWENV8fG8p7HgmdY3Nvr0PDiWujo47wCLcBGAsYHQ\/s1600\/International_journal%2Bof%2Boncology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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