{"id":31385,"date":"2019-09-25T05:30:03","date_gmt":"2019-09-25T03:30:03","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31385"},"modified":"2019-09-25T05:30:03","modified_gmt":"2019-09-25T03:30:03","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-doble-efecto-de-la-capsaicina-sobre-la-muerte-celular-en-celulas-de-osteosarcoma-humano-g292","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31385","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abDoble efecto de la capsaicina sobre la muerte celular en c\u00e9lulas de osteosarcoma humano G292\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-m35js32WdVs\/XYeNFiw4lMI\/AAAAAAAAXRg\/gfsnUZLDwZcHlNMamXRYP31R_5oZ9OmRQCLcBGAsYHQ\/s1600\/European_Journal_Pharmacology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-m35js32WdVs\/XYeNFiw4lMI\/AAAAAAAAXRg\/gfsnUZLDwZcHlNMamXRYP31R_5oZ9OmRQCLcBGAsYHQ\/s320\/European_Journal_Pharmacology.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Chien, C. S., Ma, K. H., Lee, H. S., Liu, P. S., Li, Y. H., Huang, Y. S., &amp; Chueh, S. H. (2013).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014299913006018\">Dual effect of capsaicin on cell death in human osteosarcoma G292 cells<\/a>.\u00a0<i>European journal of pharmacology<\/i>, 718(1-3), 350-360.<\/p>\n<p>El treinta por ciento de los pacientes con osteosarcoma muere dentro de los 5 a\u00f1os. Los nuevos agentes que inducen la apoptosis de las c\u00e9lulas de osteosarcoma podr\u00edan ser terap\u00e9uticamente \u00fatiles.\u00a0<\/p>\n<p>Aqu\u00ed, caracterizamos el mecanismo apopt\u00f3tico inducido por la capsaicina en las c\u00e9lulas de osteosarcoma G292.\u00a0<\/p>\n<p>Nuestros resultados muestran que la capsaicina induce un aumento en la concentraci\u00f3n citos\u00f3lica de Ca 2+ que es independiente de la concentraci\u00f3n extracelular de Ca 2+ y agota las reservas intracelulares de Ca 2+ , lo que sugiere la presencia de un potencial receptor receptor transitorio endopl\u00e1smico tipo vanilloide tipo 1.\u00a0<\/p>\n<p>La capsaicina tambi\u00e9n se activa la cascada mitocondrial caspasa 3 muerte dependiente.La rapamicina , un inhibidor del blanco mam\u00edfero de la rapamicina , evoca la autofagia , al igual que la capsaicina o la thapsigargina , uninhibidorsarco (endo) plasm\u00e1tico del ret\u00edculo Ca2+ATPasa que causa elagotamiento de la tienda deCa2+.\u00a0<\/p>\n<p>La muerte celular inducida por la capsaicina se inhibe por completo mediante el tratamiento conjunto con el inhibidor de la pancaspasa Z-VAD-fmk y aumenta por el inhibidor de la autofagia3-metiladenina , lo que sugiere la existencia de un mecanismo antiapopt\u00f3tico dependiente de la autofagia.\u00a0<\/p>\n<p>La capsaicina tambi\u00e9n induce la fosforilaci\u00f3n de ERK , que act\u00faa como un efector aguas abajo de la autofagia. 3-metiladenina o PD98059 , un inhibidor de la quinasa ERK, restaura la muerte celular inducida por capsaicina en presencia de Z-VAD-fmk, lo que sugiere que la inhibici\u00f3n de la autofagia activa una segunda v\u00eda de muerte celular que es independiente de la caspasa.\u00a0<\/p>\n<p>En conjunto, nuestros datos muestran que la capsaicina provoca Ca 2+ agotamiento intracelular de Ca 2+ tiendas y simult\u00e1neamente activa la cascada de muerte mitocondrial dependiente de caspasas y la activaci\u00f3n de ERK autofagia dependiente y que este \u00faltimo contrarresta una segunda v\u00eda de se\u00f1alizaci\u00f3n de muerte que es independiente de caspasas .<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chien, C. S., Ma, K. H., Lee, H. S., Liu, P. S., Li, Y. H., Huang, Y. S., &amp; Chueh, S. H. (2013).\u00a0Dual effect of capsaicin on cell death in human osteosarcoma G292 cells.\u00a0European journal of pharmacology, 718(1-3), 350-360. El treinta por ciento de los pacientes con osteosarcoma muere dentro de los 5 a\u00f1os. Los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-31385","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Doble efecto de la capsaicina sobre la muerte celular en c\u00e9lulas de osteosarcoma humano G292&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31385\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Doble efecto de la capsaicina sobre la muerte celular en c\u00e9lulas de osteosarcoma humano G292&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chien, C. S., Ma, K. H., Lee, H. S., Liu, P. S., Li, Y. H., Huang, Y. S., &amp; Chueh, S. H. (2013).\u00a0Dual effect of capsaicin on cell death in human osteosarcoma G292 cells.\u00a0European journal of pharmacology, 718(1-3), 350-360. El treinta por ciento de los pacientes con osteosarcoma muere dentro de los 5 a\u00f1os. 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