{"id":31557,"date":"2019-09-28T00:30:54","date_gmt":"2019-09-27T22:30:54","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31557"},"modified":"2019-09-28T00:30:54","modified_gmt":"2019-09-27T22:30:54","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-capsaicina-induce-citotoxicidad-en-celulas-mg63-de-osteosarcoma-humano-a-traves-de-vias-dependientes-e-independientes-de-trp","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31557","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina induce citotoxicidad en c\u00e9lulas MG63 de osteosarcoma humano a trav\u00e9s de v\u00edas dependientes e independientes de TRPV1\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-zdPzHVQavAY\/XY4NsW57riI\/AAAAAAAAXXk\/S93PZ3eMnkQthTvElPClKUDzZznbzCIIQCLcBGAsYHQ\/s1600\/Cell_Cycle.JPG\" \/>Bao, Z., Dai, X., Wang, P., Tao, Y., &amp; Chai, D. (2019).\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/15384101.2019.1618119\">Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and-independent pathways<\/a>.\u00a0<i>Cell Cycle<\/i>, (just-accepted).<\/p>\n<p>FONDO: Un conjunto de evidencia acumulada ha demostrado que la capsaicina induce la apoptosis en varias c\u00e9lulas tumorales como mecanismo de su actividad antitumoral. Sin embargo, los efectos de la capsaicina sobre el osteosarcoma no se han estudiado ampliamente.\u00a0<\/p>\n<p>OBJETIVO: En el estudio actual, exploramos el mecanismo molecular de la funci\u00f3n supresora de tumores mediada por capsaicina en el osteosarcoma.\u00a0<\/p>\n<p>RESULTADOS: Encontramos que la apoptosis inducida por capsaicina y la activaci\u00f3n del receptor potencial transitorio vanilloide 1 (TRPV1) de forma dependiente de la dosis y el tiempo en c\u00e9lulas MG63 de osteosarcoma humano in vitro. El bloqueo de TRPV1 con capsazepina atenu\u00f3 la citotoxicidad inducida por capsaicina, la disfunci\u00f3n mitocondrial, la sobreproducci\u00f3n de especies reactivas de ox\u00edgeno (ROS) y la disminuci\u00f3n de la actividad de la super\u00f3xido dismutasa (SOD).\u00a0<\/p>\n<p>Adem\u00e1s, los resultados demostraron que la capsaicina indujo la activaci\u00f3n de la prote\u00edna quinasa activada por monofosfato de adenosina 5\u02b9 (AMPK), p53 y quinasa N-terminal C-jun (JNK). Adem\u00e1s, el Compuesto C (antagonista de AMPK) atenu\u00f3 la activaci\u00f3n de p53, que parec\u00eda ser independiente de TRPV1.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: En conjunto, el presente estudio sugiere que la capsaicina causa efectivamente la muerte celular en las c\u00e9lulas MG63 del osteosarcoma humano a trav\u00e9s de la activaci\u00f3n de las v\u00edas dependientes de TRPV1 (disfunci\u00f3n mitocondrial y sobreproducci\u00f3n de ROS y JNK) e independientes de TRPV1 (AMPK-p53). Por lo tanto, la capsaicina puede ser un posible agente antiosteosarcoma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bao, Z., Dai, X., Wang, P., Tao, Y., &amp; Chai, D. (2019).\u00a0Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and-independent pathways.\u00a0Cell Cycle, (just-accepted). FONDO: Un conjunto de evidencia acumulada ha demostrado que la capsaicina induce la apoptosis en varias c\u00e9lulas tumorales como mecanismo de su actividad antitumoral. Sin embargo, los efectos de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-31557","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina induce citotoxicidad en c\u00e9lulas MG63 de osteosarcoma humano a trav\u00e9s de v\u00edas dependientes e independientes de TRPV1&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31557\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina induce citotoxicidad en c\u00e9lulas MG63 de osteosarcoma humano a trav\u00e9s de v\u00edas dependientes e independientes de TRPV1&quot; -\" \/>\n<meta property=\"og:description\" content=\"Bao, Z., Dai, X., Wang, P., Tao, Y., &amp; Chai, D. (2019).\u00a0Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and-independent pathways.\u00a0Cell Cycle, (just-accepted). FONDO: Un conjunto de evidencia acumulada ha demostrado que la capsaicina induce la apoptosis en varias c\u00e9lulas tumorales como mecanismo de su actividad antitumoral. Sin embargo, los efectos de la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31557\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-27T22:30:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-zdPzHVQavAY\/XY4NsW57riI\/AAAAAAAAXXk\/S93PZ3eMnkQthTvElPClKUDzZznbzCIIQCLcBGAsYHQ\/s1600\/Cell_Cycle.JPG\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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