{"id":31566,"date":"2019-09-28T03:00:31","date_gmt":"2019-09-28T01:00:31","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31566"},"modified":"2019-09-28T03:00:31","modified_gmt":"2019-09-28T01:00:31","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-capsaicina-induce-la-muerte-celular-inmunogenica-en-celulas-de-osteosarcoma-humano","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31566","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina induce la muerte celular inmunog\u00e9nica en c\u00e9lulas de osteosarcoma humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-HHnLnBfcA0s\/XY4T0TUcj2I\/AAAAAAAAXX8\/v6vcmcfYmL8-Jj_y3DDpR9LxzZgeD6l_ACLcBGAsYHQ\/s1600\/Experimental_Therapeuthic_Medicine.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-HHnLnBfcA0s\/XY4T0TUcj2I\/AAAAAAAAXX8\/v6vcmcfYmL8-Jj_y3DDpR9LxzZgeD6l_ACLcBGAsYHQ\/s1600\/Experimental_Therapeuthic_Medicine.png\" border=\"0\" data-original-width=\"192\" data-original-height=\"263\" \/><\/a>Jin, T., Wu, H., Wang, Y., &amp; Peng, H. (2016).\u00a0<a href=\"https:\/\/www.spandidos-publications.com\/etm\/12\/2\/765\">Capsaicin induces immunogenic cell death in human osteosarcoma cells<\/a>.<i>\u00a0Experimental and therapeutic medicine<\/i>, 12(2), 765-770.<\/p>\n<p>FONDO: La muerte celular inmunog\u00e9nica (DCI) se caracteriza por la exposici\u00f3n superficial temprana de calreticulina (TRC). Como una mol\u00e9cula de se\u00f1alizaci\u00f3n espec\u00edfica, la TRC en la superficie de las c\u00e9lulas tumorales apopt\u00f3ticas media el reconocimiento y la fagocitosis de las c\u00e9lulas tumorales por las c\u00e9lulas presentadoras de ant\u00edgeno. Hasta la fecha, solo se ha encontrado que una peque\u00f1a cantidad de productos qu\u00edmicos anticancer\u00edgenos inducen ICD, por lo tanto, es cl\u00ednicamente importante identificar nuevos productos qu\u00edmicos que puedan inducir ICD.\u00a0<\/p>\n<p>OBJETIVO: El prop\u00f3sito del presente estudio es explorar la funci\u00f3n de la capsaicina en la inducci\u00f3n de ICD.\u00a0<\/p>\n<p>M\u00c9TODO \/ DISE\u00d1O: En el estudio actual, se utilizaron ensayos de MTT para examinar los efectos inhibidores del crecimiento de las c\u00e9lulas MG-63 cuando se trataron con capsaicina o cisplatino. El potencial de membrana mitocondrial y el an\u00e1lisis de transferencia Western se usaron para investigar la apoptosis inducida por capsaicina y cisplatino. Adicionalmente, se evaluaron los efectos de la capsaicina y el cisplatino para determinar su capacidad para inducir la translocaci\u00f3n de la membrana de calreticulina y mediar el DAI en c\u00e9lulas de osteosarcoma humano (MG-63).\u00a0<\/p>\n<p>RESULTADOS: Los resultados demostraron que la capsaicina y el cisplatino pueden inducir la apoptosis de las c\u00e9lulas MG-63. Sin embargo, solo la capsaicina indujo una r\u00e1pida translocaci\u00f3n de la TRC desde el espacio intracelular a la superficie celular. El tratamiento con capsaicina aument\u00f3 la fagocitosis de las c\u00e9lulas MG-63 por las c\u00e9lulas dendr\u00edticas (DC), y estas DC cargadas con MG-63 podr\u00edan estimular eficientemente la secreci\u00f3n de IFN-\u03b3 por los linfocitos.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Estos resultados identifican a la capsaicina como un agente anticancer\u00edgeno capaz de inducir ICD en c\u00e9lulas de osteosarcoma humano in vitro.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jin, T., Wu, H., Wang, Y., &amp; Peng, H. (2016).\u00a0Capsaicin induces immunogenic cell death in human osteosarcoma cells.\u00a0Experimental and therapeutic medicine, 12(2), 765-770. FONDO: La muerte celular inmunog\u00e9nica (DCI) se caracteriza por la exposici\u00f3n superficial temprana de calreticulina (TRC). Como una mol\u00e9cula de se\u00f1alizaci\u00f3n espec\u00edfica, la TRC en la superficie de las c\u00e9lulas tumorales apopt\u00f3ticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-31566","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina induce la muerte celular inmunog\u00e9nica en c\u00e9lulas de osteosarcoma humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31566\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina induce la muerte celular inmunog\u00e9nica en c\u00e9lulas de osteosarcoma humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Jin, T., Wu, H., Wang, Y., &amp; Peng, H. (2016).\u00a0Capsaicin induces immunogenic cell death in human osteosarcoma cells.\u00a0Experimental and therapeutic medicine, 12(2), 765-770. FONDO: La muerte celular inmunog\u00e9nica (DCI) se caracteriza por la exposici\u00f3n superficial temprana de calreticulina (TRC). Como una mol\u00e9cula de se\u00f1alizaci\u00f3n espec\u00edfica, la TRC en la superficie de las c\u00e9lulas tumorales apopt\u00f3ticas [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31566\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-28T01:00:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-HHnLnBfcA0s\/XY4T0TUcj2I\/AAAAAAAAXX8\/v6vcmcfYmL8-Jj_y3DDpR9LxzZgeD6l_ACLcBGAsYHQ\/s1600\/Experimental_Therapeuthic_Medicine.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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