{"id":31569,"date":"2019-09-28T04:30:13","date_gmt":"2019-09-28T02:30:13","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31569"},"modified":"2019-09-28T04:30:13","modified_gmt":"2019-09-28T02:30:13","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-capsaicina-inhibe-la-proliferacion-e-induce-la-apoptosis-en-las-lineas-celulares-de-osteosarcoma-a-traves-de-la-via-de-la-pr","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31569","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina inhibe la proliferaci\u00f3n e induce la apoptosis en las l\u00edneas celulares de osteosarcoma a trav\u00e9s de la v\u00eda de la prote\u00edna quinasa activada por mit\u00f3geno\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-6RlwyfL6HN8\/XY4WUKdmXpI\/AAAAAAAAXYE\/LhhvMJQtSNox9c8q7_1itrr21SQ4uNtuACLcBGAsYHQ\/s1600\/Oncology_Reports.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-6RlwyfL6HN8\/XY4WUKdmXpI\/AAAAAAAAXYE\/LhhvMJQtSNox9c8q7_1itrr21SQ4uNtuACLcBGAsYHQ\/s1600\/Oncology_Reports.jpg\" border=\"0\" data-original-width=\"230\" data-original-height=\"320\" \/><\/a>Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G., &#8230; &amp; Jiang, D. (2017).\u00a0<a href=\"https:\/\/www.spandidos-publications.com\/or\/38\/5\/2685\">Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen\u2011activated protein kinase pathway<\/a>.<i>\u00a0Oncology reports<\/i>, 38(5), 2685-2696.<\/p>\n<p>FONDO: La capsaicina, un compuesto molecular picante presente en muchos pimientos picantes, ejerce actividades contra el c\u00e1ncer contra diversas l\u00edneas celulares de c\u00e1ncer humano al inducir la apoptosis. Sin embargo, los efectos de la capsaicina sobre el osteosarcoma humano (SG), as\u00ed como los mecanismos relacionados, a\u00fan no se han dilucidado por completo.\u00a0<\/p>\n<p>OBJETIVO: En el presente estudio, se investigaron los efectos anticancer\u00edgenos de la capsaicina en 3 l\u00edneas celulares OS humanas (MG63, 143B y HOS).\u00a0<\/p>\n<p>M\u00c9TODO \/ RESULTADOS: Diversas concentraciones de capsaicina (50-300 \u00b5M) disminuyeron efectivamente la viabilidad celular en las 3 l\u00edneas celulares OS de una manera dependiente de la dosis. En particular, se observ\u00f3 apoptosis inducida por capsaicina cuando las c\u00e9lulas OS se trataron con concentraciones relativamente altas de capsaicina (a partir de 250 \u00b5M). Adem\u00e1s, la v\u00eda apopt\u00f3tica mitocondrial estuvo involucrada en la apoptosis inducida por capsaicina en las c\u00e9lulas OS.\u00a0<\/p>\n<p>Mientras tanto, nuestros resultados tambi\u00e9n indicaron que a concentraciones relativamente bajas (p. ej., 100 \u00b5M), la capsaicina podr\u00eda inhibir la proliferaci\u00f3n, disminuir la capacidad de formaci\u00f3n de colonias e inducir la detenci\u00f3n del ciclo celular en fase G0 \/ G1 de las c\u00e9lulas OS de una manera dependiente de la dosis. Adem\u00e1s, nuestros resultados revelaron que los efectos anticancer\u00edgenos inducidos por la capsaicina en las l\u00edneas celulares de OS involucraron m\u00faltiples rutas de se\u00f1alizaci\u00f3n de MAPK como lo indica la inactivaci\u00f3n de las rutas ERK1 \/ 2 y p38 y la activaci\u00f3n de la ruta JNK. Adem\u00e1s, los resultados de los experimentos con animales mostraron que la capsaicina inhibi\u00f3 el crecimiento tumoral en un modelo de xenoinjerto de OS humano.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, estos resultados indican que la capsaicina puede ejercer beneficios terap\u00e9uticos como un complemento de las terapias actuales contra el c\u00e1ncer, pero no como un agente independiente contra el c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G., &#8230; &amp; Jiang, D. (2017).\u00a0Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen\u2011activated protein kinase pathway.\u00a0Oncology reports, 38(5), 2685-2696. FONDO: La capsaicina, un compuesto molecular picante presente en muchos pimientos picantes, ejerce actividades contra el c\u00e1ncer contra diversas l\u00edneas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-31569","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina inhibe la proliferaci\u00f3n e induce la apoptosis en las l\u00edneas celulares de osteosarcoma a trav\u00e9s de la v\u00eda de la prote\u00edna quinasa activada por mit\u00f3geno&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31569\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina inhibe la proliferaci\u00f3n e induce la apoptosis en las l\u00edneas celulares de osteosarcoma a trav\u00e9s de la v\u00eda de la prote\u00edna quinasa activada por mit\u00f3geno&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhang, Y., Deng, X., Lei, T., Yu, C., Wang, Y., Zhao, G., &#8230; &amp; Jiang, D. (2017).\u00a0Capsaicin inhibits proliferation and induces apoptosis in osteosarcoma cell lines via the mitogen\u2011activated protein kinase pathway.\u00a0Oncology reports, 38(5), 2685-2696. FONDO: La capsaicina, un compuesto molecular picante presente en muchos pimientos picantes, ejerce actividades contra el c\u00e1ncer contra diversas l\u00edneas [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31569\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-28T02:30:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-6RlwyfL6HN8\/XY4WUKdmXpI\/AAAAAAAAXYE\/LhhvMJQtSNox9c8q7_1itrr21SQ4uNtuACLcBGAsYHQ\/s1600\/Oncology_Reports.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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