{"id":31572,"date":"2019-09-28T05:30:57","date_gmt":"2019-09-28T03:30:57","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31572"},"modified":"2019-09-28T05:30:57","modified_gmt":"2019-09-28T03:30:57","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-efectos-inhibidores-sinergicos-de-la-capsaicina-combinada-con-cisplatino-sobre-el-osteosarcoma-humano-en-cultivo-y-en-xenoinjer","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31572","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos inhibidores sin\u00e9rgicos de la capsaicina combinada con cisplatino sobre el osteosarcoma humano en cultivo y en xenoinjertos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-jbycAqKnfhs\/XY4YYAXKObI\/AAAAAAAAXYM\/dF2cQO9TMzgIhf1S3OtT8VlPq3ezmaetACLcBGAsYHQ\/s1600\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-jbycAqKnfhs\/XY4YYAXKObI\/AAAAAAAAXYM\/dF2cQO9TMzgIhf1S3OtT8VlPq3ezmaetACLcBGAsYHQ\/s320\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg\" width=\"225\" height=\"320\" border=\"0\" data-original-width=\"306\" data-original-height=\"434\" \/><\/a>Wang, Y., Deng, X., Yu, C., Zhao, G., Zhou, J., Zhang, G., &#8230; &amp; Zhang, Y. (2018).\u00a0<a href=\"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-018-0922-0\">Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts<\/a>.\u00a0<i>Journal of Experimental &amp; Clinical Cancer Research<\/i>, 37(1), 251.<\/p>\n<p>ANTECEDENTES: La combinaci\u00f3n de fitoqu\u00edmicos con medicamentos de quimioterapia es una nueva estrategia emergente para la terapia del c\u00e1ncer para aumentar las respuestas antitumorales.<\/p>\n<p>M\u00c9TODOS: El presente estudio investiga el efecto de la combinaci\u00f3n de capsaicina (CAP) con cisplatino (DDP) y los posibles mecanismos anticancer\u00edgenos subyacentes en las c\u00e9lulas de osteosarcoma (OS) in vitro e in vivo.<\/p>\n<p>RESULTADOS: Los ensayos de viabilidad celular y los an\u00e1lisis isobologr\u00e1ficos demostraron que la combinaci\u00f3n de CAP y DDP mostr\u00f3 efectos citot\u00f3xicos sin\u00e9rgicos en las c\u00e9lulas OS. Elegimos concentraciones relativamente bajas de CAP (100 \u03bcM) y DDP (16.7 \u03bcM) para experimentos posteriores. En general, la combinaci\u00f3n de CAP y DDP tuvo efectos significativos sobre la inducci\u00f3n de apoptosis, la detenci\u00f3n del ciclo celular y la inhibici\u00f3n de la invasi\u00f3n celular en c\u00e9lulas OS en comparaci\u00f3n con los grupos de tratamiento individual y el grupo control. Adem\u00e1s, el cotratamiento con CAP y DDP desencaden\u00f3 la autofagia de la supervivencia a trav\u00e9s de la se\u00f1alizaci\u00f3n de especies reactivas de ox\u00edgeno (ROS) \/ JNK y p-AKT \/ mTOR en c\u00e9lulas OS. El r\u00e9gimen de combinaci\u00f3n de CAP y DDP tambi\u00e9n inhibi\u00f3 el crecimiento tumoral en un modelo de xenoinjerto de OS.<\/p>\n<p>CONCLUSI\u00d3N: Estos resultados sugieren que la combinaci\u00f3n de CAP y DDP tiene fuertes efectos inhibitorios en las c\u00e9lulas OS e identifican a CAP como un agente prometedor para complementar la quimioterapia est\u00e1ndar y la posible terapia dirigida futura en OS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang, Y., Deng, X., Yu, C., Zhao, G., Zhou, J., Zhang, G., &#8230; &amp; Zhang, Y. (2018).\u00a0Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts.\u00a0Journal of Experimental &amp; Clinical Cancer Research, 37(1), 251. ANTECEDENTES: La combinaci\u00f3n de fitoqu\u00edmicos con medicamentos de quimioterapia es una nueva estrategia emergente para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-31572","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos inhibidores sin\u00e9rgicos de la capsaicina combinada con cisplatino sobre el osteosarcoma humano en cultivo y en xenoinjertos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31572\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos inhibidores sin\u00e9rgicos de la capsaicina combinada con cisplatino sobre el osteosarcoma humano en cultivo y en xenoinjertos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wang, Y., Deng, X., Yu, C., Zhao, G., Zhou, J., Zhang, G., &#8230; &amp; Zhang, Y. (2018).\u00a0Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts.\u00a0Journal of Experimental &amp; Clinical Cancer Research, 37(1), 251. ANTECEDENTES: La combinaci\u00f3n de fitoqu\u00edmicos con medicamentos de quimioterapia es una nueva estrategia emergente para [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31572\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-28T03:30:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-jbycAqKnfhs\/XY4YYAXKObI\/AAAAAAAAXYM\/dF2cQO9TMzgIhf1S3OtT8VlPq3ezmaetACLcBGAsYHQ\/s320\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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