{"id":31952,"date":"2019-10-08T00:30:02","date_gmt":"2019-10-07T22:30:02","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31952"},"modified":"2019-10-08T00:30:02","modified_gmt":"2019-10-07T22:30:02","slug":"area-de-conocimiento-naturopatia-descriptiva-el-efecto-de-los-inhibidores-de-la-hmg-coa-reductasa-sobre-la-coenzima-q10-posibles-implicaciones-bioquimicas-clinicas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31952","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl efecto de los inhibidores de la HMG-CoA reductasa sobre la coenzima Q10: posibles implicaciones bioqu\u00edmicas \/ cl\u00ednicas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-qlDsrPSbm1c\/XZifo9OA53I\/AAAAAAAAXlU\/fV3d6Lx7jjEDCpFXuLU5MqhRr_0Fu-bZACLcBGAsYHQ\/s1600\/Drug_safety.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-qlDsrPSbm1c\/XZifo9OA53I\/AAAAAAAAXlU\/fV3d6Lx7jjEDCpFXuLU5MqhRr_0Fu-bZACLcBGAsYHQ\/s320\/Drug_safety.jpg\" width=\"237\" height=\"320\" border=\"0\" data-original-width=\"306\" data-original-height=\"412\" \/><\/a>Hargreaves, I. P., Duncan, A. J., Heales, S. J., &amp; Land, J. M. (2005).\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.2165\/00002018-200528080-00002\">The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q 10<\/a>.\u00a0<i>Drug safety<\/i>, 28(8), 659-676.<\/p>\n<p>Los inhibidores de la HMG-CoA reductasa, tambi\u00e9n conocidos como estatinas, tienen un perfil de seguridad envidiable; sin embargo, se ha observado mioxicidad y, en menor medida, hepatotoxicidad en algunos pacientes despu\u00e9s del tratamiento.\u00a0<\/p>\n<p>Las estatinas se dirigen a varios tejidos, dependiendo de su lipofilia, donde inhiben competitivamente la HMG-CoA reductasa, la enzima limitante de la velocidad para la s\u00edntesis de \u00e1cido meval\u00f3nico y, posteriormente, la bios\u00edntesis de colesterol. La HMG-CoA reductasa es tambi\u00e9n el primer paso limitante de velocidad comprometido para la s\u00edntesis de una variedad de otros compuestos, incluidas las hormonas esteroides y la ubidecarenona (ubiquinona), tambi\u00e9n conocida como coenzima Q (10) (CoQ (10)).\u00a0<\/p>\n<p>El inter\u00e9s reciente se ha centrado en el posible papel que la deficiencia de CoQ (10) puede tener en la fisiopatolog\u00eda de los efectos adversos raros del tratamiento con estatinas. Actualmente, no hay pruebas suficientes de estudios en humanos para vincular inequ\u00edvocamente la terapia con estatinas a niveles de CoQ (10) tisular significativamente disminuidos patol\u00f3gicamente. Aunque se ha informado que el tratamiento con estatinas reduce el estado de CoQ (10) en plasma \/ suero, pocos estudios en humanos han evaluado el estado de CoQ (10) en los tejidos. El nivel de CoQ en plasma \/ suero (10) est\u00e1 influenciado por una serie de factores fisiol\u00f3gicos y, por lo tanto, tiene un valor limitado como medio para evaluar el estado de CoQ (10) intracelular.\u00a0<\/p>\n<p>En aquellos estudios limitados que han evaluado el efecto del tratamiento con estatinas sobre los niveles de CoQ (10) en los tejidos, ninguno ha mostrado evidencia de una ca\u00edda en los niveles de CoQ (10). Esto puede reflejar las dosis de estatinas utilizadas, ya que muchas parecen haber sido utilizadas en dosis inferiores a las recomendadas por sus efectos terap\u00e9uticos m\u00e1ximos. Adem\u00e1s, La pobre biodisponibilidad en los tejidos perif\u00e9ricos analizados puede no reflejar los efectos que los agentes est\u00e1n teniendo en el h\u00edgado y los m\u00fasculos, los tejidos com\u00fanmente afectados en aquellos pacientes que no toleran las estatinas.\u00a0<\/p>\n<p>Este art\u00edculo revisa la bioqu\u00edmica de CoQ (10), su papel en el metabolismo celular y la evidencia disponible que vincula la posible deficiencia de CoQ (10) con la terapia con estatinas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hargreaves, I. P., Duncan, A. J., Heales, S. J., &amp; Land, J. M. (2005).\u00a0The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q 10.\u00a0Drug safety, 28(8), 659-676. Los inhibidores de la HMG-CoA reductasa, tambi\u00e9n conocidos como estatinas, tienen un perfil de seguridad envidiable; sin embargo, se ha observado mioxicidad y, en menor medida, hepatotoxicidad en algunos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-31952","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El efecto de los inhibidores de la HMG-CoA reductasa sobre la coenzima Q10: posibles implicaciones bioqu\u00edmicas \/ cl\u00ednicas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31952\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El efecto de los inhibidores de la HMG-CoA reductasa sobre la coenzima Q10: posibles implicaciones bioqu\u00edmicas \/ cl\u00ednicas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hargreaves, I. 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Los inhibidores de la HMG-CoA reductasa, tambi\u00e9n conocidos como estatinas, tienen un perfil de seguridad envidiable; sin embargo, se ha observado mioxicidad y, en menor medida, hepatotoxicidad en algunos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31952\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-07T22:30:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-qlDsrPSbm1c\/XZifo9OA53I\/AAAAAAAAXlU\/fV3d6Lx7jjEDCpFXuLU5MqhRr_0Fu-bZACLcBGAsYHQ\/s320\/Drug_safety.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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