{"id":31964,"date":"2019-10-08T02:30:19","date_gmt":"2019-10-08T00:30:19","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31964"},"modified":"2019-10-08T02:30:19","modified_gmt":"2019-10-08T00:30:19","slug":"area-de-conocimiento-naturopatia-descriptiva-inhibidores-de-la-hmg-coa-reductasa-y-miotoxicidad","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31964","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abInhibidores de la HMG-CoA reductasa y miotoxicidad\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-xqYctRlsgwM\/XZiwnT82OrI\/AAAAAAAAXls\/ff2AMJQVeAg71zLhPTRnoBKHEYydVd1awCLcBGAsYHQ\/s1600\/Drug_safety.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-xqYctRlsgwM\/XZiwnT82OrI\/AAAAAAAAXls\/ff2AMJQVeAg71zLhPTRnoBKHEYydVd1awCLcBGAsYHQ\/s320\/Drug_safety.jpg\" width=\"237\" height=\"320\" border=\"0\" data-original-width=\"306\" data-original-height=\"412\" \/><\/a>Ucar, M., Mj\u00f6rndal, T., &amp; Dahlqvist, R. (2000).<a href=\"https:\/\/link.springer.com\/article\/10.2165\/00002018-200022060-00003\">\u00a0HMG-CoA reductase inhibitors and myotoxicity.<\/a>\u00a0<i>Drug safety<\/i>, 22(6), 441-457.<\/p>\n<p>Los inhibidores de la 3-hidroxi-3-metilglutaril coenzima A (HMG-CoA) reductasa inhiben espec\u00edficamente la HMG-CoA reductasa en el h\u00edgado, inhibiendo as\u00ed la bios\u00edntesis de colesterol. Estos medicamentos reducen significativamente el nivel de colesterol en plasma y el tratamiento a largo plazo reduce la morbilidad y la mortalidad asociadas con la enfermedad coronaria. La tolerabilidad de estos medicamentos durante la administraci\u00f3n a largo plazo es un tema importante.\u00a0<\/p>\n<p>Las reacciones adversas que involucran el m\u00fasculo esquel\u00e9tico no son infrecuentes, y a veces pueden ocurrir reacciones adversas graves que involucran el m\u00fasculo esquel\u00e9tico, como la miopat\u00eda y la rabdomi\u00f3lisis, que requieren la interrupci\u00f3n del medicamento. Ocasionalmente, se ha informado artralgia, sola o en asociaci\u00f3n con mialgia.\u00a0<\/p>\n<p>En este art\u00edculo revisamos los datos cient\u00edficos proporcionados a trav\u00e9s de Medline, informes de casos de reacciones farmacol\u00f3gicas adversas del Sistema de Informaci\u00f3n de Medicamentos de Suecia (SWEDIS) y la base de datos del Sistema Internacional de Informaci\u00f3n de Medicamentos de la Organizaci\u00f3n Mundial de la Salud (INTDIS), centr\u00e1ndose en eventos del sistema musculoesquel\u00e9tico relacionados con el inhibidor de la HMG-CoA.\u00a0<\/p>\n<p>El citocromo P450 (CYP) 3A4 es la principal isoenzima involucrada en la transformaci\u00f3n metab\u00f3lica de los inhibidores de la HMG-CoA reductasa. Las personas con bajos niveles de expresi\u00f3n de CYP3A4 en el tracto hep\u00e1tico y bajo del tracto gastrointestinal pueden tener un mayor riesgo de miotoxicidad debido a concentraciones plasm\u00e1ticas de inhibidor de reductasa HMG-CoA potencialmente m\u00e1s altas. La incidencia informada de reacciones miot\u00f3xicas en pacientes tratados con esta clase de drogas var\u00eda del 1 al 7% y var\u00eda entre los diferentes agentes.\u00a0<\/p>\n<p>El riesgo de estas reacciones adversas graves depende de la dosis y puede aumentar cuando los inhibidores de la HMG-CoA reductasa se recetan concomitantemente con medicamentos que inhiben su metabolismo, como itraconazol, ciclosporina, eritromicina y nefazodona. Las alteraciones electrol\u00edticas, las infecciones, los traumatismos graves, la hipoxia y las abusos de medicamentos pueden aumentar el riesgo de miotoxicidad.\u00a0<\/p>\n<p>Es importante que las reacciones adversas potencialmente graves se reconozcan y se diagnostiquen correctamente para que el inhibidor de la reductasa HMG-CoA se pueda retirar de inmediato para evitar un mayor da\u00f1o muscular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ucar, M., Mj\u00f6rndal, T., &amp; Dahlqvist, R. (2000).\u00a0HMG-CoA reductase inhibitors and myotoxicity.\u00a0Drug safety, 22(6), 441-457. Los inhibidores de la 3-hidroxi-3-metilglutaril coenzima A (HMG-CoA) reductasa inhiben espec\u00edficamente la HMG-CoA reductasa en el h\u00edgado, inhibiendo as\u00ed la bios\u00edntesis de colesterol. Estos medicamentos reducen significativamente el nivel de colesterol en plasma y el tratamiento a largo plazo reduce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-31964","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Inhibidores de la HMG-CoA reductasa y miotoxicidad&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31964\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Inhibidores de la HMG-CoA reductasa y miotoxicidad&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ucar, M., Mj\u00f6rndal, T., &amp; Dahlqvist, R. (2000).\u00a0HMG-CoA reductase inhibitors and myotoxicity.\u00a0Drug safety, 22(6), 441-457. Los inhibidores de la 3-hidroxi-3-metilglutaril coenzima A (HMG-CoA) reductasa inhiben espec\u00edficamente la HMG-CoA reductasa en el h\u00edgado, inhibiendo as\u00ed la bios\u00edntesis de colesterol. Estos medicamentos reducen significativamente el nivel de colesterol en plasma y el tratamiento a largo plazo reduce [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=31964\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-08T00:30:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-xqYctRlsgwM\/XZiwnT82OrI\/AAAAAAAAXls\/ff2AMJQVeAg71zLhPTRnoBKHEYydVd1awCLcBGAsYHQ\/s320\/Drug_safety.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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