{"id":31966,"date":"2019-10-08T03:30:28","date_gmt":"2019-10-08T01:30:28","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=31966"},"modified":"2019-10-08T03:30:28","modified_gmt":"2019-10-08T01:30:28","slug":"area-de-conocimiento-naturopatia-descriptiva-la-lovastatina-disminuye-los-niveles-de-coenzima-q-en-humanos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=31966","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abLa lovastatina disminuye los niveles de coenzima Q en humanos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Voic9oYjCnc\/XZiyThnXClI\/AAAAAAAAXl0\/syEYv8DC0P4xf6iDAqCoUVKndQlSUKdbQCLcBGAsYHQ\/s1600\/Proceedings_National_Academy_Sciences_USA.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Voic9oYjCnc\/XZiyThnXClI\/AAAAAAAAXl0\/syEYv8DC0P4xf6iDAqCoUVKndQlSUKdbQCLcBGAsYHQ\/s320\/Proceedings_National_Academy_Sciences_USA.jpg\" width=\"241\" height=\"320\" border=\"0\" data-original-width=\"350\" data-original-height=\"463\" \/><\/a>Folkers, K., Langsjoen, P., Willis, R., Richardson, P., Xia, L. J., Ye, C. Q., &amp; Tamagawa, H. (1990).\u00a0<a href=\"https:\/\/www.pnas.org\/content\/pnas\/87\/22\/8931.full.pdf\">Lovastatin decreases coenzyme Q levels in humans<\/a>.\u00a0<i>Proceedings of the National Academy of Sciences<\/i>, 87(22), 8931-8934.<\/p>\n<p>La lovastatina se usa cl\u00ednicamente para tratar pacientes con hipercolesterolemia y reduce con \u00e9xito los niveles de colesterol. El mecanismo de acci\u00f3n de la lovastatina es la inhibici\u00f3n de la 3-hidroxi-3-metilglutaril-coenzima A reductasa, una enzima involucrada en la bios\u00edntesis de colesterol a partir de acetil-CoA. La inhibici\u00f3n de esta enzima tambi\u00e9n podr\u00eda inhibir la bios\u00edntesis intr\u00ednseca de la coenzima Q10 (CoQ10), pero no ha habido datos definitivos sobre si la lovastatina reduce los niveles de CoQ10 al igual que el colesterol. El uso cl\u00ednico de la lovastatina es reducir el riesgo de enfermedad card\u00edaca, y si la lovastatina redujera los niveles de CoQ10, esta reducci\u00f3n constituir\u00eda un nuevo riesgo de enfermedad card\u00edaca, ya que se establece que la CoQ10 es indispensable para la funci\u00f3n card\u00edaca.\u00a0<\/p>\n<p>Hemos realizado tres protocolos relacionados para determinar si la lovastatina realmente inhibe la bios\u00edntesis de CoQ10. Se realiz\u00f3 un protocolo en ratas, y se informa en el documento anterior [Willis, RA, Folkers, K., Tucker, JL, Ye, C.-Q., Xia, L.-J. Y Tamagawa, H. (1990) Proc. Natl. Acad. Sci. USA 87, 8928-8930]. Los otros dos protocolos se informan aqu\u00ed. Uno involucr\u00f3 a pacientes en un hospital y el otro a un voluntario que permiti\u00f3 un monitoreo extraordinario de CoQ10 y los niveles de colesterol y la funci\u00f3n card\u00edaca.\u00a0<\/p>\n<p>Todos los datos de los tres protocolos revelaron que la lovastatina reduce los niveles de CoQ10. Los cinco pacientes hospitalizados, de 43 a 72 a\u00f1os de edad, revelaron un aumento de la enfermedad card\u00edaca por lovastatina, que era potencialmente mortal para los pacientes con miocardiopat\u00eda de clase IV antes de la lovastatina o despu\u00e9s de tomar lovastatina.\u00a0<\/p>\n<p>La administraci\u00f3n oral de CoQ10 aument\u00f3 los niveles sangu\u00edneos de CoQ10 y generalmente estuvo acompa\u00f1ada de una mejora en la funci\u00f3n card\u00edaca. Aunque es un f\u00e1rmaco exitoso, la lovastatina tiene efectos secundarios, en particular, incluyendo disfunci\u00f3n hep\u00e1tica, que presumiblemente puede ser causada por la deficiencia de CoQ10 inducida por lovastatina.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Folkers, K., Langsjoen, P., Willis, R., Richardson, P., Xia, L. J., Ye, C. Q., &amp; Tamagawa, H. (1990).\u00a0Lovastatin decreases coenzyme Q levels in humans.\u00a0Proceedings of the National Academy of Sciences, 87(22), 8931-8934. La lovastatina se usa cl\u00ednicamente para tratar pacientes con hipercolesterolemia y reduce con \u00e9xito los niveles de colesterol. El mecanismo de acci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-31966","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La lovastatina disminuye los niveles de coenzima Q en humanos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=31966\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;La lovastatina disminuye los niveles de coenzima Q en humanos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Folkers, K., Langsjoen, P., Willis, R., Richardson, P., Xia, L. J., Ye, C. Q., &amp; Tamagawa, H. (1990).\u00a0Lovastatin decreases coenzyme Q levels in humans.\u00a0Proceedings of the National Academy of Sciences, 87(22), 8931-8934. La lovastatina se usa cl\u00ednicamente para tratar pacientes con hipercolesterolemia y reduce con \u00e9xito los niveles de colesterol. 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