{"id":32097,"date":"2019-10-10T00:30:42","date_gmt":"2019-10-09T22:30:42","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=32097"},"modified":"2019-10-10T00:30:42","modified_gmt":"2019-10-09T22:30:42","slug":"area-de-conocimiento-naturopatia-descriptiva-estres-oxidativo-y-complicaciones-diabeticas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=32097","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEstr\u00e9s oxidativo y complicaciones diab\u00e9ticas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-9r1cfYRzAiQ\/XZ41JnKGakI\/AAAAAAAAXq0\/PD22nq20PNcu9BHCWvvAqOOB0KHaz-WIwCLcBGAsYHQ\/s1600\/Circulation_research.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-9r1cfYRzAiQ\/XZ41JnKGakI\/AAAAAAAAXq0\/PD22nq20PNcu9BHCWvvAqOOB0KHaz-WIwCLcBGAsYHQ\/s320\/Circulation_research.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"300\" data-original-height=\"400\" \/><\/a>Giacco, F., &amp; Brownlee, M. (2010). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2996922\/\">Oxidative stress and diabetic complications<\/a>. <i>Circulation research<\/i>, 107(9), 1058-1070.<\/p>\n<p>El estr\u00e9s oxidativo desempe\u00f1a un papel fundamental en el desarrollo de complicaciones de la diabetes, tanto microvasculares como cardiovasculares. Las anormalidades metab\u00f3licas de la diabetes causan la sobreproducci\u00f3n de super\u00f3xido mitocondrial en las c\u00e9lulas endoteliales de los vasos grandes y peque\u00f1os, y tambi\u00e9n en el miocardio. <\/p>\n<p>Este aumento en la producci\u00f3n de super\u00f3xido provoca la activaci\u00f3n de cinco v\u00edas principales involucradas en la patog\u00e9nesis de las complicaciones: flujo de la ruta del poliol, aumento de la formaci\u00f3n de productos finales de glicaci\u00f3n avanzada (AGE), aumento de la expresi\u00f3n del receptor para los AGE y sus ligandos activadores, activaci\u00f3n de la prote\u00edna quinasa C (PKC) isoformas y hiperactividad de la v\u00eda de la hexosamina. <\/p>\n<p>Tambi\u00e9n inactiva directamente dos enzimas antiateroscler\u00f3ticas cr\u00edticas, eNOS y prostaciclina sintasa. A trav\u00e9s de estos caminos, ll aumento de ROS intracelular causa una angiog\u00e9nesis defectuosa en respuesta a la isquemia, activa varias v\u00edas proinflamatorias y provoca cambios epigen\u00e9ticos duraderos que impulsan la expresi\u00f3n persistente de genes proinflamatorios despu\u00e9s de que la glucemia se normaliza (\u00abmemoria hipergluc\u00e9mica \u00bb). <\/p>\n<p>La aterosclerosis y la miocardiopat\u00eda en la diabetes tipo 2 son causadas en parte por la resistencia a la insulina selectiva de la ruta, lo que aumenta la producci\u00f3n de ROS mitocondriales a partir de \u00e1cidos grasos libres y por la inactivaci\u00f3n de las enzimas anti-aterosclerosis por ROS. La sobreexpresi\u00f3n de super\u00f3xido dismutasa en ratones diab\u00e9ticos transg\u00e9nicos previene la retinopat\u00eda, la nefropat\u00eda y la miocardiopat\u00eda diab\u00e9ticas. <\/p>\n<p>El objetivo de esta revisi\u00f3n es destacar los avances en la comprensi\u00f3n del papel de las ROS generadas por metabolitos en el desarrollo de complicaciones diab\u00e9ticas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Giacco, F., &amp; Brownlee, M. (2010). Oxidative stress and diabetic complications. Circulation research, 107(9), 1058-1070. El estr\u00e9s oxidativo desempe\u00f1a un papel fundamental en el desarrollo de complicaciones de la diabetes, tanto microvasculares como cardiovasculares. Las anormalidades metab\u00f3licas de la diabetes causan la sobreproducci\u00f3n de super\u00f3xido mitocondrial en las c\u00e9lulas endoteliales de los vasos grandes y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-32097","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo y complicaciones diab\u00e9ticas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=32097\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo y complicaciones diab\u00e9ticas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Giacco, F., &amp; Brownlee, M. (2010). Oxidative stress and diabetic complications. Circulation research, 107(9), 1058-1070. El estr\u00e9s oxidativo desempe\u00f1a un papel fundamental en el desarrollo de complicaciones de la diabetes, tanto microvasculares como cardiovasculares. Las anormalidades metab\u00f3licas de la diabetes causan la sobreproducci\u00f3n de super\u00f3xido mitocondrial en las c\u00e9lulas endoteliales de los vasos grandes y [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=32097\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-09T22:30:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-9r1cfYRzAiQ\/XZ41JnKGakI\/AAAAAAAAXq0\/PD22nq20PNcu9BHCWvvAqOOB0KHaz-WIwCLcBGAsYHQ\/s320\/Circulation_research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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