{"id":32530,"date":"2019-10-22T06:30:42","date_gmt":"2019-10-22T04:30:42","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=32530"},"modified":"2019-10-22T06:30:42","modified_gmt":"2019-10-22T04:30:42","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-boldine-un-alcaloide-natural-de-aporfina-inhibe-la-telomerasa-en-concentraciones-no-toxicas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=32530","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abBoldine, un alcaloide natural de aporfina, inhibe la telomerasa en concentraciones no t\u00f3xicas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--oMoD00sQ1U\/Xatn2nrLYlI\/AAAAAAAAX8g\/6TfB2pGWW-0sGqeobnVOJhfCpua2a2kCQCLcBGAsYHQ\/s1600\/Chemico_Biological%2BInteractions.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--oMoD00sQ1U\/Xatn2nrLYlI\/AAAAAAAAX8g\/6TfB2pGWW-0sGqeobnVOJhfCpua2a2kCQCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Noureini, S. K., &amp; Tanavar, F. (2015).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0009279715000897\">Boldine, a natural aporphine alkaloid, inhibits telomerase at non-toxic concentrations.<\/a>\u00a0<i>Chemico-biological interactions<\/i>, 231, 27-34.\u00a0<\/p>\n<p>En un estudio preliminar de detecci\u00f3n de alcaloides naturales, boldina, un alcaloide de la aporfina, mostr\u00f3 una dosis interesante y efecto antiproliferativo dependiente del tiempo en varias l\u00edneas de c\u00e9lulas cancerosas.\u00a0<\/p>\n<p>La citotoxicidad de boldina en fibroblastos humanos fue considerablemente m\u00e1s baja que la del ri\u00f1\u00f3n embrionario positivo a la telomerasa HEK293 y las c\u00e9lulas de c\u00e1ncer de mama MCF-7 y MDA-MB-231. Si la boldina puede inhibir la telomerasa se investig\u00f3 aqu\u00ed usando un protocolo cuantitativo de amplificaci\u00f3n de repetici\u00f3n de tel\u00f3meros en tiempo real modificado (q-TRAP).\u00a0<\/p>\n<p>Esta prueba demostr\u00f3 que boldina inhibe la telomerasa en c\u00e9lulas tratadas con concentraciones sub-citot\u00f3xicas. La inhibici\u00f3n de la telomerasa se produce a trav\u00e9s de la regulaci\u00f3n negativa de hTERT, la subunidad catal\u00edtica de la enzima. Boldina tambi\u00e9n cambi\u00f3 las variantes de empalme de hTERT hacia transcripciones no funcionales m\u00e1s cortas.\u00a0<\/p>\n<p>Tambi\u00e9n puede estar involucrada una interacci\u00f3n directa de boldina con la enzima, aunque el m\u00e9todo FRET t\u00e9rmico no detect\u00f3 ninguna interacci\u00f3n sustancial entre las secuencias de tel\u00f3meros de boldina y sint\u00e9ticas.\u00a0<\/p>\n<p>Este estudio defiende a boldina como un valioso candidato para la atenci\u00f3n del c\u00e1ncer dirigida a la telomerasa. Este estudio sugiere que los derivados de boldina podr\u00edan ser potentes medicamentos contra el c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Noureini, S. K., &amp; Tanavar, F. (2015).\u00a0Boldine, a natural aporphine alkaloid, inhibits telomerase at non-toxic concentrations.\u00a0Chemico-biological interactions, 231, 27-34.\u00a0 En un estudio preliminar de detecci\u00f3n de alcaloides naturales, boldina, un alcaloide de la aporfina, mostr\u00f3 una dosis interesante y efecto antiproliferativo dependiente del tiempo en varias l\u00edneas de c\u00e9lulas cancerosas.\u00a0 La citotoxicidad de boldina en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-32530","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Boldine, un alcaloide natural de aporfina, inhibe la telomerasa en concentraciones no t\u00f3xicas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=32530\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Boldine, un alcaloide natural de aporfina, inhibe la telomerasa en concentraciones no t\u00f3xicas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Noureini, S. 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(2015).\u00a0Boldine, a natural aporphine alkaloid, inhibits telomerase at non-toxic concentrations.\u00a0Chemico-biological interactions, 231, 27-34.\u00a0 En un estudio preliminar de detecci\u00f3n de alcaloides naturales, boldina, un alcaloide de la aporfina, mostr\u00f3 una dosis interesante y efecto antiproliferativo dependiente del tiempo en varias l\u00edneas de c\u00e9lulas cancerosas.\u00a0 La citotoxicidad de boldina en [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=32530\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-22T04:30:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/--oMoD00sQ1U\/Xatn2nrLYlI\/AAAAAAAAX8g\/6TfB2pGWW-0sGqeobnVOJhfCpua2a2kCQCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" 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