{"id":32951,"date":"2019-11-01T04:30:32","date_gmt":"2019-11-01T02:30:32","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=32951"},"modified":"2019-11-01T04:30:32","modified_gmt":"2019-11-01T02:30:32","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-carnosol-controla-las-caracteristicas-de-la-madurez-del-glioblastoma-humano-a-traves-de-la-modulacion-de-transicion-epitelial-m","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=32951","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abCarnosol controla las caracter\u00edsticas de la madurez del glioblastoma humano a trav\u00e9s de la modulaci\u00f3n de transici\u00f3n epitelial-mesenquimal y la inducci\u00f3n de apoptosis de c\u00e9lulas madre cancerosas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-RwiYcqydmYY\/Xbqzf3TCHyI\/AAAAAAAAYLU\/pbh4mStIJB8Yg4SepFMwnqQR00qCz_etQCLcBGAsYHQ\/s1600\/scientific_reports.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-RwiYcqydmYY\/Xbqzf3TCHyI\/AAAAAAAAYLU\/pbh4mStIJB8Yg4SepFMwnqQR00qCz_etQCLcBGAsYHQ\/s320\/scientific_reports.jpg\" width=\"243\" height=\"320\" border=\"0\" data-original-width=\"638\" data-original-height=\"839\" \/><\/a>Giacomelli, C., Daniele, S., Natali, L., Iofrida, C., Flamini, G., Braca, A., &#8230; &amp; Martini, C. (2017).\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41598-017-15360-2\">Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.<\/a>\u00a0<i>Scientific reports<\/i>, 7(1), 15174.<\/p>\n<p>CONTEXTO: Una alta tasa de proliferaci\u00f3n celular, invasividad y resistencia a la quimioterapia son las principales caracter\u00edsticas del glioblastoma (GBM). La agresividad de GBM se ha asociado ampliamente con una poblaci\u00f3n menor de c\u00e9lulas que presentan propiedades similares a las del tallo (c\u00e9lulas similares al c\u00e1ncer, CSC) y con la capacidad de las c\u00e9lulas tumorales para adquirir un fenotipo mesenquimatoso (transici\u00f3n epitelial-mesenquimal, EMT). El carnosol (CAR), un inhibidor natural del complejo MDM2 \/ p53, ha atra\u00eddo la atenci\u00f3n por sus efectos anticancer\u00edgenos en varios tipos de tumores, incluido el GBM.\u00a0<\/p>\n<p>OBJETIVO \/ M\u00c9TODO: Aqu\u00ed, se evaluaron los efectos de CAR sobre la viabilidad de CSC derivada de U87MG y las caracter\u00edsticas de la potencia.\u00a0<\/p>\n<p>RESULTADOS: CAR disminuy\u00f3 la tasa de formaci\u00f3n de CSC y promovi\u00f3 la muerte celular apopt\u00f3tica de CSC a trav\u00e9s de la reactivaci\u00f3n funcional de p53. Adem\u00e1s, CAR pudo controlar la EMT inducida por TNF-\u03b1 \/ TGF-\u03b2, contrarrestando los efectos de la citocina en los genes reguladores maestros de EMT (Slug, Snail, Twist y ZEB1) y modulando la activaci\u00f3n de miR-200c, un jugador clave en el proceso de EMT. Finalmente, CAR pudo aumentar los efectos antiproliferativos de la temozolomida (TMZ).\u00a0<\/p>\n<p>CONCLUSI\u00d3N: Estos hallazgos demuestran que CAR afect\u00f3 a los diferentes mecanismos intracelulares de la compleja maquinaria que regula la potencia de GBM. Por primera vez, el diterpeno se destac\u00f3 como una ventaja prometedora para el desarrollo de agentes capaces de disminuir las caracter\u00edsticas de la potencia, controlando as\u00ed la agresividad de GBM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Giacomelli, C., Daniele, S., Natali, L., Iofrida, C., Flamini, G., Braca, A., &#8230; &amp; Martini, C. (2017).\u00a0Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.\u00a0Scientific reports, 7(1), 15174. CONTEXTO: Una alta tasa de proliferaci\u00f3n celular, invasividad y resistencia a la quimioterapia son las principales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-32951","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Carnosol controla las caracter\u00edsticas de la madurez del glioblastoma humano a trav\u00e9s de la modulaci\u00f3n de transici\u00f3n epitelial-mesenquimal y la inducci\u00f3n de apoptosis de c\u00e9lulas madre cancerosas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=32951\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Carnosol controla las caracter\u00edsticas de la madurez del glioblastoma humano a trav\u00e9s de la modulaci\u00f3n de transici\u00f3n epitelial-mesenquimal y la inducci\u00f3n de apoptosis de c\u00e9lulas madre cancerosas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Giacomelli, C., Daniele, S., Natali, L., Iofrida, C., Flamini, G., Braca, A., &#8230; &amp; Martini, C. (2017).\u00a0Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis.\u00a0Scientific reports, 7(1), 15174. 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