{"id":32957,"date":"2019-11-01T06:30:21","date_gmt":"2019-11-01T04:30:21","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=32957"},"modified":"2019-11-01T06:30:21","modified_gmt":"2019-11-01T04:30:21","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-acido-ursolico-desencadena-la-apoptosis-y-la-regulacion-negativa-de-bcl-2-en-celulas-de-cancer-de-mama-mcf-7","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=32957","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido urs\u00f3lico desencadena la apoptosis y la regulaci\u00f3n negativa de Bcl-2 en c\u00e9lulas de c\u00e1ncer de mama MCF-7\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-1TgO9nacVPE\/Xbq4KYALs2I\/AAAAAAAAYLk\/Ti8q7L-WxjwuTqx1S0gQDuPMeuegxELpACLcBGAsYHQ\/s1600\/Cancer_investigation.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-1TgO9nacVPE\/Xbq4KYALs2I\/AAAAAAAAYLk\/Ti8q7L-WxjwuTqx1S0gQDuPMeuegxELpACLcBGAsYHQ\/s320\/Cancer_investigation.png\" width=\"233\" height=\"320\" border=\"0\" data-original-width=\"400\" data-original-height=\"548\" \/><\/a>Kassi, E., Sourlingas, T. G., Spiliotaki, M., Papoutsi, Z., Pratsinis, H., Aligiannis, N., &amp; Moutsatsou, P. (2009).\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07357900802672712?src=recsys\">Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells<\/a>.\u00a0<i>Cancer investigation<\/i>, 27(7), 723-733.<\/p>\n<p>En este informe determinamos la capacidad del \u00e1cido urs\u00f3lico (UA) para inducir apoptosis y modular el receptor de glucocorticoides (GR) yi la prote\u00edna activadora-1 (AP-1) en c\u00e9lulas MCF-7.\u00a0<\/p>\n<p>La apoptosis inducida por UA (53 \u03bcM), la escisi\u00f3n de PARP y la disminuci\u00f3n de la prote\u00edna Bcl-2 (53 \u03bcM) apoyan la noci\u00f3n de que UA induce la apoptosis a trav\u00e9s de la v\u00eda mitocondrial intr\u00ednseca. UA se une a GR (afinidad de uni\u00f3n relativa: 2.57) y transloca a GR en el n\u00facleo, lo que sugiere su potencial como modulador de GR. UA no tuvo efecto sobre la expresi\u00f3n g\u00e9nica dirigida por GRE o TRE.<\/p>\n<p>En resumen, UA es un modulador GR y puede considerarse como un posible agente anticancer\u00edgeno en el c\u00e1ncer de mama.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kassi, E., Sourlingas, T. G., Spiliotaki, M., Papoutsi, Z., Pratsinis, H., Aligiannis, N., &amp; Moutsatsou, P. (2009).\u00a0Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells.\u00a0Cancer investigation, 27(7), 723-733. En este informe determinamos la capacidad del \u00e1cido urs\u00f3lico (UA) para inducir apoptosis y modular el receptor de glucocorticoides (GR) yi la prote\u00edna activadora-1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-32957","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El \u00e1cido urs\u00f3lico desencadena la apoptosis y la regulaci\u00f3n negativa de Bcl-2 en c\u00e9lulas de c\u00e1ncer de mama MCF-7&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=32957\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El \u00e1cido urs\u00f3lico desencadena la apoptosis y la regulaci\u00f3n negativa de Bcl-2 en c\u00e9lulas de c\u00e1ncer de mama MCF-7&quot; -\" \/>\n<meta property=\"og:description\" content=\"Kassi, E., Sourlingas, T. G., Spiliotaki, M., Papoutsi, Z., Pratsinis, H., Aligiannis, N., &amp; Moutsatsou, P. (2009).\u00a0Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells.\u00a0Cancer investigation, 27(7), 723-733. En este informe determinamos la capacidad del \u00e1cido urs\u00f3lico (UA) para inducir apoptosis y modular el receptor de glucocorticoides (GR) yi la prote\u00edna activadora-1 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=32957\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-01T04:30:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-1TgO9nacVPE\/Xbq4KYALs2I\/AAAAAAAAYLk\/Ti8q7L-WxjwuTqx1S0gQDuPMeuegxELpACLcBGAsYHQ\/s320\/Cancer_investigation.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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