{"id":33077,"date":"2019-11-04T00:30:48","date_gmt":"2019-11-03T22:30:48","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33077"},"modified":"2019-11-04T00:30:48","modified_gmt":"2019-11-03T22:30:48","slug":"area-de-conocimiento-naturopatia-descriptiva-el-metabolismo-de-la-glucosa-y-la-via-de-la-hexosamina-regulan-la-senescencia-inducida-por-el-oncogen","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33077","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl metabolismo de la glucosa y la v\u00eda de la hexosamina regulan la senescencia inducida por el oncog\u00e9n\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-cnyvjBtQMP4\/Xb3aPOsrYFI\/AAAAAAAAYPo\/VMVDpw5PLjg7FtsNDX1gLbSB0r4OpEJ1ACLcBGAsYHQ\/s1600\/Cell_Death_Disease.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-cnyvjBtQMP4\/Xb3aPOsrYFI\/AAAAAAAAYPo\/VMVDpw5PLjg7FtsNDX1gLbSB0r4OpEJ1ACLcBGAsYHQ\/s1600\/Cell_Death_Disease.jpg\" border=\"0\" data-original-width=\"130\" data-original-height=\"175\" \/><\/a>Gitenay, D., Wiel, C., Lallet-Daher, H., Vindrieux, D., Aubert, S., Payen, L., &#8230; &amp; Bernard, D. (2014).\u00a0<a href=\"https:\/\/www.nature.com\/articles\/cddis201463\">Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence<\/a>.\u00a0<i>Cell death &amp; disease<\/i>, 5(2), e1089.<\/p>\n<p>La senescencia inducida por el estr\u00e9s oncog\u00e9nico (OIS) impide la capacidad de las se\u00f1ales oncog\u00e9nicas para inducir la tumorig\u00e9nesis.\u00a0<\/p>\n<p>Ahora se admite en gran medida que el efecto mitog\u00e9nico de los oncogenes requiere adaptaciones metab\u00f3licas para responder a las nuevas necesidades energ\u00e9ticas y bioconstituyentes. Sin embargo, se desconoce en gran medida si el metabolismo de la glucosa afecta la respuesta OIS. Esto se debe en gran parte al hecho de que la mayor\u00eda de los modelos celulares OIS se cultivan en exceso de glucosa.\u00a0<\/p>\n<p>En este estudio, utilizamos c\u00e9lulas epiteliales humanas, cultivadas sin exceso de glucosa, para estudiar la alteraci\u00f3n y el papel funcional del metabolismo de la glucosa durante la OIS. Informamos una desaceleraci\u00f3n de la captaci\u00f3n de glucosa y el metabolismo durante OIS.\u00a0<\/p>\n<p>El aumento del metabolismo de la glucosa al expresar hexoquinasa2 (HK2), que convierte la glucosa en glucosa-6-fosfato (G6P), favorece el escape de OIS. Inversamente, expresando una glucosa-6-fosfatasa, La inhibici\u00f3n farmacol\u00f3gica [corregida] de HK2, o la adici\u00f3n de glucosa no metabolizable indujo una senescencia prematura. Las manipulaciones de varios metabolitos que cubren las v\u00edas aguas abajo de G6P (v\u00edas de hexosamina, gluc\u00f3lisis y fosfato de pentosa) sugieren un papel inesperado de la v\u00eda de hexosamina en el control de OIS.\u00a0<\/p>\n<p>En conjunto, nuestros resultados muestran que el metabolismo de glucosa disminuido ocurre durante y participa en OIS.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gitenay, D., Wiel, C., Lallet-Daher, H., Vindrieux, D., Aubert, S., Payen, L., &#8230; &amp; Bernard, D. (2014).\u00a0Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence.\u00a0Cell death &amp; disease, 5(2), e1089. La senescencia inducida por el estr\u00e9s oncog\u00e9nico (OIS) impide la capacidad de las se\u00f1ales oncog\u00e9nicas para inducir la tumorig\u00e9nesis.\u00a0 Ahora se admite en gran medida que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33077","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El metabolismo de la glucosa y la v\u00eda de la hexosamina regulan la senescencia inducida por el oncog\u00e9n&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33077\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El metabolismo de la glucosa y la v\u00eda de la hexosamina regulan la senescencia inducida por el oncog\u00e9n&quot; -\" \/>\n<meta property=\"og:description\" content=\"Gitenay, D., Wiel, C., Lallet-Daher, H., Vindrieux, D., Aubert, S., Payen, L., &#8230; &amp; Bernard, D. (2014).\u00a0Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence.\u00a0Cell death &amp; disease, 5(2), e1089. La senescencia inducida por el estr\u00e9s oncog\u00e9nico (OIS) impide la capacidad de las se\u00f1ales oncog\u00e9nicas para inducir la tumorig\u00e9nesis.\u00a0 Ahora se admite en gran medida que [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33077\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-03T22:30:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-cnyvjBtQMP4\/Xb3aPOsrYFI\/AAAAAAAAYPo\/VMVDpw5PLjg7FtsNDX1gLbSB0r4OpEJ1ACLcBGAsYHQ\/s1600\/Cell_Death_Disease.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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