{"id":33085,"date":"2019-11-04T03:30:55","date_gmt":"2019-11-04T01:30:55","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33085"},"modified":"2019-11-04T03:30:55","modified_gmt":"2019-11-04T01:30:55","slug":"area-de-conocimiento-naturopatia-descriptiva-metabolismo-glucolitico-aberrante-de-las-celulas-cancerosas-una-notable-coordinacion-de-eventos-geneticos-transcripcionales-postraduccionales-y-muta","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33085","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abMetabolismo glucol\u00edtico aberrante de las c\u00e9lulas cancerosas: una notable coordinaci\u00f3n de eventos gen\u00e9ticos, transcripcionales, postraduccionales y mutacionales que conducen a un papel cr\u00edtico para la hexoquinasa tipo II\u00bb"},"content":{"rendered":"

<\/a>Mathupala, S. P., Rempel, A., & Pedersen, P. L. (1997).\u00a0Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.\u00a0<\/a>Journal of bioenergetics and biomembranes<\/i>, 29(4), 339-343.<\/p>\n

Durante m\u00e1s de dos tercios de este siglo, hemos sabido que uno de los fenotipos m\u00e1s comunes y profundos de las c\u00e9lulas cancerosas es su propensi\u00f3n a utilizar y catabolizar la glucosa a altas tasas. Esta firma bioqu\u00edmica com\u00fan de muchos tipos de c\u00e1ncer, particularmente aquellos que est\u00e1n pobremente diferenciados y proliferan r\u00e1pidamente, ha permanecido hasta hace poco como un \u00abenigma metab\u00f3lico\u00bb. Sin embargo, con muchos avances en las ciencias biol\u00f3gicas que se han aplicado a este problema, las c\u00e9lulas cancerosas han comenzado a revelar sus estrategias moleculares para mantener un comportamiento metab\u00f3lico aberrante.\u00a0<\/p>\n

Espec\u00edficamente, los estudios realizados en las \u00faltimas dos d\u00e9cadas en nuestro laboratorio demuestran que la hexoquinasa, particularmente la isoforma tipo II, desempe\u00f1a un papel cr\u00edtico en el inicio y mantenimiento de las altas tasas catab\u00f3licas de glucosa de los tumores que crecen r\u00e1pidamente. Esta enzima convierte la glucosa entrante en glucosa-6-fosfato, el intermedio fosforilado inicial de la v\u00eda glucol\u00edtica y un precursor importante de muchos \u00abbloques de construcci\u00f3n\u00bb celulares.\u00a0<\/p>\n

A nivel gen\u00e9tico, la c\u00e9lula tumoral se adapta metab\u00f3licamente aumentando primero el n\u00famero de copias de genes de la hexoquinasa tipo II. El promotor del gen de la enzima, a su vez, muestra una gran promiscuidad hacia las cascadas de transducci\u00f3n de se\u00f1ales activas dentro de las c\u00e9lulas tumorales. Se activa por glucosa, insulina, condiciones \u00abhip\u00f3xicas\u00bb de bajo ox\u00edgeno y \u00e9steres de forbol, que mejoran la tasa de transcripci\u00f3n.\u00a0<\/p>\n

Adem\u00e1s, la c\u00e9lula tumoral usa el supresor tumoral p53, que generalmente se modifica por mutaciones para debilitar los controles del ciclo celular, para activar a\u00fan m\u00e1s la transcripci\u00f3n del gen de la hexoquinasa.\u00a0<\/p>\n

Esto da como resultado ambos niveles mejorados de la enzima, que se une a las porinas mitocondriales, obteniendo as\u00ed acceso preferencial al ATP generado mitocondrialmente, y con una menor susceptibilidad a la inhibici\u00f3n del producto y la degradaci\u00f3n proteol\u00edtica. Significativamente, estas m\u00faltiples estrategias funcionan juntas para permitir que las c\u00e9lulas tumorales desarrollen una estrategia metab\u00f3lica compatible con la r\u00e1pida proliferaci\u00f3n y la supervivencia prolongada.<\/p>\n","protected":false},"excerpt":{"rendered":"

Mathupala, S. P., Rempel, A., & Pedersen, P. L. (1997).\u00a0Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.\u00a0Journal of bioenergetics and biomembranes, 29(4), 339-343. Durante m\u00e1s de dos tercios de este siglo, hemos sabido que uno de los […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33085","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Metabolismo glucol\u00edtico aberrante de las c\u00e9lulas cancerosas: una notable coordinaci\u00f3n de eventos gen\u00e9ticos, transcripcionales, postraduccionales y mutacionales que conducen a un papel cr\u00edtico para la hexoquinasa tipo II" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33085\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Metabolismo glucol\u00edtico aberrante de las c\u00e9lulas cancerosas: una notable coordinaci\u00f3n de eventos gen\u00e9ticos, transcripcionales, postraduccionales y mutacionales que conducen a un papel cr\u00edtico para la hexoquinasa tipo II" -\" \/>\n<meta property=\"og:description\" content=\"Mathupala, S. P., Rempel, A., & Pedersen, P. L. (1997).\u00a0Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.\u00a0Journal of bioenergetics and biomembranes, 29(4), 339-343. 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