{"id":33138,"date":"2019-11-06T02:30:43","date_gmt":"2019-11-06T00:30:43","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33138"},"modified":"2019-11-06T02:30:43","modified_gmt":"2019-11-06T00:30:43","slug":"area-de-conocimiento-naturopatia-descriptiva-regulacion-del-metabolismo-de-la-glucosa-por-6-fosfofructo-2-quinasa-fructosa-26-bisfosfatasas-en-cancer","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33138","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abRegulaci\u00f3n del metabolismo de la glucosa por 6-fosfofructo-2-quinasa \/ fructosa-2,6-bisfosfatasas en c\u00e1ncer\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-FhfFrHuxDkE\/Xb7Z98oQGzI\/AAAAAAAAYSg\/SdFVNHCOim4VcNBGDL74vmQNKzKVRXeuwCLcBGAsYHQ\/s1600\/Experimental_molecular%2Bpathology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-FhfFrHuxDkE\/Xb7Z98oQGzI\/AAAAAAAAYSg\/SdFVNHCOim4VcNBGDL74vmQNKzKVRXeuwCLcBGAsYHQ\/s320\/Experimental_molecular%2Bpathology.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Yalcin, A., Telang, S., Clem, B., &amp; Chesney, J. (2009).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014480009000082\">Regulation of glucose metabolism by 6-phosphofructo-2-kinase\/fructose-2, 6-bisphosphatases in cancer<\/a>.\u00a0<i>Experimental and molecular pathology,<\/i>\u00a086(3), 174-179.<\/p>\n<p>Una alta tasa de flujo glucol\u00edtico, incluso en presencia de ox\u00edgeno, es un sello metab\u00f3lico central de los tumores neopl\u00e1sicos. Las c\u00e9lulas cancerosas utilizan preferentemente la gluc\u00f3lisis para satisfacer sus mayores requisitos energ\u00e9ticos y biosint\u00e9ticos. Este fenotipo metab\u00f3lico ha sido confirmado en estudios en humanos utilizando tomograf\u00eda por emisi\u00f3n de positrones (PET) con (18) F-2-fluoro-desoxi-glucosa que han demostrado que los tumores absorben 10 veces m\u00e1s glucosa que los tejidos normales adyacentes in vivo.<\/p>\n<p>El alto metabolismo de la glucosa de las c\u00e9lulas cancerosas es causado por una combinaci\u00f3n de factores de transcripci\u00f3n que responden a la hipoxia, la activaci\u00f3n de prote\u00ednas oncog\u00e9nicas y la p\u00e9rdida de la funci\u00f3n supresora de tumores. Sobreexpresi\u00f3n de HIF-1 alfa y myc, se ha encontrado que la activaci\u00f3n de ras y la p\u00e9rdida de la funci\u00f3n p53 estimulan la gluc\u00f3lisis en parte al activar una familia de 6-fosfofructo-2-quinasa \/ fructosa-2,6-bisfosfatasas bifuncionales reguladoras (PFKFB). Las enzimas PFKFB sintetizan fructosa-2,6-bisfosfato (F2,6BP) que activa alost\u00e9ricamente la 6-fosfofructo-1-quinasa (PFK-1), una enzima limitante de la velocidad y un punto de control esencial en la v\u00eda glucol\u00edtica. El ATP inhibe el PFK-1 cuando las reservas de energ\u00eda son abundantes y el F2,6BP puede anular esta inhibici\u00f3n y mejorar la absorci\u00f3n de glucosa y el flujo glucol\u00edtico.<\/p>\n<p>Por lo tanto, no es sorprendente que la s\u00edntesis de F2,6BP sea estimulada por varias alteraciones oncog\u00e9nicas que simult\u00e1neamente causan un mayor consumo de glucosa y crecimiento. Es importante destacar que estos estudios sugieren que el agotamiento selectivo de F2 intracelular, el 6BP en las c\u00e9lulas cancerosas puede suprimir el flujo glucol\u00edtico y disminuir su supervivencia, crecimiento e invasividad.<\/p>\n<p>Esta revisi\u00f3n resumir\u00e1 el requisito de la 6-fosfofructo-2-quinasa \/ fructosa-2,6-bisfosfatasas para la regulaci\u00f3n de la gluc\u00f3lisis en las c\u00e9lulas tumorales y su potencial utilidad como objetivos para el desarrollo de agentes antineopl\u00e1sicos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yalcin, A., Telang, S., Clem, B., &amp; Chesney, J. (2009).\u00a0Regulation of glucose metabolism by 6-phosphofructo-2-kinase\/fructose-2, 6-bisphosphatases in cancer.\u00a0Experimental and molecular pathology,\u00a086(3), 174-179. Una alta tasa de flujo glucol\u00edtico, incluso en presencia de ox\u00edgeno, es un sello metab\u00f3lico central de los tumores neopl\u00e1sicos. Las c\u00e9lulas cancerosas utilizan preferentemente la gluc\u00f3lisis para satisfacer sus mayores requisitos energ\u00e9ticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33138","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Regulaci\u00f3n del metabolismo de la glucosa por 6-fosfofructo-2-quinasa \/ fructosa-2,6-bisfosfatasas en c\u00e1ncer&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33138\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Regulaci\u00f3n del metabolismo de la glucosa por 6-fosfofructo-2-quinasa \/ fructosa-2,6-bisfosfatasas en c\u00e1ncer&quot; -\" \/>\n<meta property=\"og:description\" content=\"Yalcin, A., Telang, S., Clem, B., &amp; Chesney, J. (2009).\u00a0Regulation of glucose metabolism by 6-phosphofructo-2-kinase\/fructose-2, 6-bisphosphatases in cancer.\u00a0Experimental and molecular pathology,\u00a086(3), 174-179. Una alta tasa de flujo glucol\u00edtico, incluso en presencia de ox\u00edgeno, es un sello metab\u00f3lico central de los tumores neopl\u00e1sicos. Las c\u00e9lulas cancerosas utilizan preferentemente la gluc\u00f3lisis para satisfacer sus mayores requisitos energ\u00e9ticos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33138\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T00:30:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-FhfFrHuxDkE\/Xb7Z98oQGzI\/AAAAAAAAYSg\/SdFVNHCOim4VcNBGDL74vmQNKzKVRXeuwCLcBGAsYHQ\/s320\/Experimental_molecular%2Bpathology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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