{"id":33140,"date":"2019-11-06T03:30:36","date_gmt":"2019-11-06T01:30:36","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33140"},"modified":"2019-11-06T03:30:36","modified_gmt":"2019-11-06T01:30:36","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-inhibe-la-glucolisis-aerobica-e-induce-apoptosis-mediada-por-mitocondrias-a-traves-de-la-hexoquinasa-ii-en-celulas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33140","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina inhibe la gluc\u00f3lisis aer\u00f3bica e induce apoptosis mediada por mitocondrias a trav\u00e9s de la hexoquinasa II en c\u00e9lulas de c\u00e1ncer colorrectal humano in vitro\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" border=\"0\" data-original-width=\"160\" data-original-height=\"213\" \/><\/a>Wang, K., Fan, H., Chen, Q., Ma, G., Zhu, M., Zhang, X., &#8230; &amp; Yu, J. (2015).\u00a0<a href=\"https:\/\/journals.lww.com\/anti-cancerdrugs\/Abstract\/2015\/01000\/Curcumin_inhibits_aerobic_glycolysis_and_induces.2.aspx\">Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro<\/a>.\u00a0<i>Anti-cancer drugs<\/i>, 26(1), 15-24.<\/p>\n<div>La curcumina , el pigmento principal de la c\u00farcuma de especias en la dieta, tiene el potencial de quimioprevenci\u00f3n mediante la promoci\u00f3n de la apoptosis.\u00a0<\/p>\n<p>Aqu\u00ed, investigamos los mecanismos moleculares de la curcumina en la inhibici\u00f3n glucol\u00edtica y la inducci\u00f3n apopt\u00f3tica en las c\u00e9lulas HCT116 y HT29 del c\u00e1ncer colorrectal humano.\u00a0<\/p>\n<p>Por un lado, la curcumina regulaba negativamente la expresi\u00f3n y la actividad de la hexoquinasa II (HKII) en las c\u00e9lulas HCT116 y HT29 de forma dependiente de la concentraci\u00f3n, pero ten\u00eda poco efecto sobre las otras enzimas glucol\u00edticas clave (PFK, PGM y LDH).\u00a0<\/p>\n<p>Por otro lado, la curcumina indujo la disociaci\u00f3n de HKII de las mitocondrias, lo que result\u00f3 en una apoptosis mediada por mitocondrias . Adem\u00e1s, la fosforilaci\u00f3n de mitocondriasHKII a trav\u00e9s de AKT fue responsable de la disociaci\u00f3n inducida por la curcumina de HKII, que era diferente del mecanismo del inhibidor de HKII 3-BrPA.\u00a0<\/p>\n<p>Estos resultados tienen implicaciones importantes para el efecto de reprogramaci\u00f3n del metabolismo y la susceptibilidad a la citotoxicidad mitocondrial inducida por la curcumina a trav\u00e9s de la regulaci\u00f3n de HKII, y proporcionan una base molecular para el desarrollo de compuestos naturales como nuevos agentes anticancer\u00edgenos para el carcinoma colorrectal.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Wang, K., Fan, H., Chen, Q., Ma, G., Zhu, M., Zhang, X., &#8230; &amp; Yu, J. (2015).\u00a0Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.\u00a0Anti-cancer drugs, 26(1), 15-24. La curcumina , el pigmento principal de la c\u00farcuma de especias en la dieta, tiene el potencial de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33140","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la gluc\u00f3lisis aer\u00f3bica e induce apoptosis mediada por mitocondrias a trav\u00e9s de la hexoquinasa II en c\u00e9lulas de c\u00e1ncer colorrectal humano in vitro&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33140\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la gluc\u00f3lisis aer\u00f3bica e induce apoptosis mediada por mitocondrias a trav\u00e9s de la hexoquinasa II en c\u00e9lulas de c\u00e1ncer colorrectal humano in vitro&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wang, K., Fan, H., Chen, Q., Ma, G., Zhu, M., Zhang, X., &#8230; &amp; Yu, J. (2015).\u00a0Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.\u00a0Anti-cancer drugs, 26(1), 15-24. La curcumina , el pigmento principal de la c\u00farcuma de especias en la dieta, tiene el potencial de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33140\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T01:30:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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