{"id":33142,"date":"2019-11-06T04:30:36","date_gmt":"2019-11-06T02:30:36","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33142"},"modified":"2019-11-06T04:30:36","modified_gmt":"2019-11-06T02:30:36","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-carvacrol-inhibe-la-proliferacion-e-induce-apoptosis-en-celulas-de-cancer-de-colon-humano","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33142","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abCarvacrol inhibe la proliferaci\u00f3n e induce apoptosis en c\u00e9lulas de c\u00e1ncer de colon humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" border=\"0\" data-original-width=\"160\" data-original-height=\"213\" \/><\/a>Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., &amp; Sun, H. (2015).\u00a0<a href=\"https:\/\/journals.lww.com\/anti-cancerdrugs\/Abstract\/2015\/09000\/Carvacrol_inhibits_proliferation_and_induces.3.aspx\">Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells<\/a>.\u00a0<i>Anti-cancer drugs<\/i>, 26(8), 813-823.<\/p>\n<p>FONDO: El c\u00e1ncer de colon es una de las neoplasias malignas m\u00e1s comunes en todo el mundo y tiene una alta tasa de mortalidad. El carvacrol es un componente principal de los aceites esenciales de or\u00e9gano y tomillo y muestra propiedades antitumorales.\u00a0<\/p>\n<p>OBJETIVO \/ M\u00c9TODO: Aqu\u00ed, investigamos los efectos del carvacrol en la proliferaci\u00f3n y apoptosis de dos l\u00edneas celulares de c\u00e1ncer de colon humano , HCT116 y LoVo, y estudiamos los mecanismos moleculares de sus propiedades antitumorales.\u00a0<\/p>\n<p>RESULTADOS: Descubrimos que el carvacrol inhib\u00eda la proliferaci\u00f3n y migraci\u00f3n de las dos l\u00edneas celulares de c\u00e1ncer de colon de manera dependiente de la concentraci\u00f3n. La invasi\u00f3n celular fue suprimida despu\u00e9s del tratamiento con carvacrol mediante la disminuci\u00f3n de la expresi\u00f3n de matriz metaloproteasa-2 (MMP-2) y MMP-9. El tratamiento con carvacrol tambi\u00e9n caus\u00f3 la detenci\u00f3n del ciclo celular en la fase G2 \/ M y disminuy\u00f3 la expresi\u00f3n de ciclina B1. Finalmente, el carvacrol indujo la apoptosis celular de una manera dependiente de la dosis. A nivel molecular, el carvacrol regulaba negativamente la expresi\u00f3n de Bcl-2 e induc\u00eda la fosforilaci\u00f3n de la prote\u00edna quinasa regulada extracelular y la prote\u00edna quinasa B (p-Akt). Paralelamente, el carvacrol regulaba positivamente la expresi\u00f3n de Bax y c-Jun N-terminal quinasa.\u00a0<\/p>\n<p>CONCLUSIONES: Estos resultados indican que el carvacrol puede inducir apoptosis en el c\u00e1ncer de colon.c\u00e9lulas a trav\u00e9s de la v\u00eda apopt\u00f3tica mitocondrial y las v\u00edas de se\u00f1alizaci\u00f3n MAPK y PI3K \/ Akt. Juntos, nuestros resultados sugieren que el carvacrol puede tener potencial terap\u00e9utico para la prevenci\u00f3n y el tratamiento del c\u00e1ncer de colon .<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., &amp; Sun, H. (2015).\u00a0Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells.\u00a0Anti-cancer drugs, 26(8), 813-823. FONDO: El c\u00e1ncer de colon es una de las neoplasias malignas m\u00e1s comunes en todo el mundo y tiene una alta tasa de mortalidad. El carvacrol [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33142","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Carvacrol inhibe la proliferaci\u00f3n e induce apoptosis en c\u00e9lulas de c\u00e1ncer de colon humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33142\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Carvacrol inhibe la proliferaci\u00f3n e induce apoptosis en c\u00e9lulas de c\u00e1ncer de colon humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., &amp; Sun, H. (2015).\u00a0Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells.\u00a0Anti-cancer drugs, 26(8), 813-823. FONDO: El c\u00e1ncer de colon es una de las neoplasias malignas m\u00e1s comunes en todo el mundo y tiene una alta tasa de mortalidad. El carvacrol [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33142\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T02:30:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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