{"id":33144,"date":"2019-11-06T05:30:06","date_gmt":"2019-11-06T03:30:06","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33144"},"modified":"2019-11-06T05:30:06","modified_gmt":"2019-11-06T03:30:06","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-acido-clorogenico-induce-la-generacion-reactiva-de-especies-de-oxigeno-e-inhibe-la-viabilidad-de-las-celulas-de-cancer-de-co","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33144","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" border=\"0\" data-original-width=\"160\" data-original-height=\"213\" \/><\/a>Hou, N., Liu, N., Han, J., Yan, Y., &amp; Li, J. (2017).\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Ni_Hou\/publication\/307622495_Chlorogenic_acid_induces_reactive_oxygen_species_generation_and_inhibits_the_viability_of_human_colon_cancer_cells\/links\/59e4a898aca2724cbfe92fc1\/Chlorogenic-acid-induces-reactive-oxygen-species-generation-and-inhibits-the-viability-of-human-colon-cancer-cells.pdf\">Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells<\/a>.\u00a0<i>Anti-cancer drug<\/i>s, 28(1), 59-65.<\/p>\n<p>FONDO: El \u00e1cido clorog\u00e9nico (CGA) es uno de los polifenoles identificados en la dieta humana. Estudios anteriores han demostrado que CGA juega un papel protector contra las enfermedades del h\u00edgado. El colon juega un papel fundamental en el metabolismo de la CGA. Sin embargo, se sabe poco sobre los efectos directos y los mecanismos moleculares subyacentes de la CGA en el c\u00e1ncer de colon.\u00a0<\/p>\n<p>OBJETIVO: Aqu\u00ed, investigamos estos mecanismos de actividad de CGA en c\u00e9lulas de c\u00e1ncer de colon humano.\u00a0<\/p>\n<p>M\u00c9TODO \/ DISE\u00d1O: Los efectos de CGA sobre la viabilidad de dos l\u00edneas celulares de c\u00e1ncer de colon humano , HCT116 y HT29, se determinaron utilizando el ensayo MTT. La especie de ox\u00edgeno reactivo intracelular(ROS) se detectaron mediante microscop\u00eda de fluorescencia y citometr\u00eda de flujo. Adem\u00e1s, se detectaron cambios en la proliferaci\u00f3n celular mediante an\u00e1lisis del ciclo celular. El an\u00e1lisis de inmunotransferencia se utiliz\u00f3 para observar los cambios moleculares subyacentes.\u00a0<\/p>\n<p>RESULTADOS: CGA inhibi\u00f3 la viabilidad de las c\u00e9lulas HCT116 y HT29 de una manera dependiente de la dosis. La CGA indujo la producci\u00f3n de ROS, mientras que el uso combinado del eliminador de ROS N- acetilciste\u00edna atenu\u00f3 la inhibici\u00f3n de la viabilidad inducida por CGA . Adem\u00e1s, la CGA indujo la detenci\u00f3n del ciclo celular en la fase S y suprimi\u00f3 la activaci\u00f3n de la quinasa relacionada con la se\u00f1al extracelular en ambos tipos de c\u00e9lulas, lo que probablemente contribuye a la inhibici\u00f3n de la viabilidad inducida por ROS causado por el tratamiento CGA. La producci\u00f3n de ROS inducida por CGA inhibi\u00f3 la viabilidad celular en c\u00e9lulas de c\u00e1ncer de colon humano. La CGA caus\u00f3 la detenci\u00f3n de la fase S y la inactivaci\u00f3n de la quinasa relacionada con la se\u00f1al extracelular que puede haber conducido a la inhibici\u00f3n de la viabilidad observada .\u00a0<\/p>\n<p>CONCLUSI\u00d3N: La CGA es, por lo tanto, un tratamiento potencial contra el CCR.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hou, N., Liu, N., Han, J., Yan, Y., &amp; Li, J. (2017).\u00a0Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells.\u00a0Anti-cancer drugs, 28(1), 59-65. FONDO: El \u00e1cido clorog\u00e9nico (CGA) es uno de los polifenoles identificados en la dieta humana. Estudios anteriores han demostrado que CGA juega un papel protector [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33144","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hou, N., Liu, N., Han, J., Yan, Y., &amp; Li, J. (2017).\u00a0Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells.\u00a0Anti-cancer drugs, 28(1), 59-65. FONDO: El \u00e1cido clorog\u00e9nico (CGA) es uno de los polifenoles identificados en la dieta humana. Estudios anteriores han demostrado que CGA juega un papel protector [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T03:30:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\u00bb\",\"datePublished\":\"2019-11-06T03:30:06+00:00\",\"dateModified\":\"2019-11-06T03:30:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\"},\"wordCount\":404,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=33144#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2019-11-06T03:30:06+00:00\",\"dateModified\":\"2019-11-06T03:30:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=33144\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=33144#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=33144","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\" -","og_description":"Hou, N., Liu, N., Han, J., Yan, Y., &amp; Li, J. (2017).\u00a0Chlorogenic acid induces reactive oxygen species generation and inhibits the viability of human colon cancer cells.\u00a0Anti-cancer drugs, 28(1), 59-65. FONDO: El \u00e1cido clorog\u00e9nico (CGA) es uno de los polifenoles identificados en la dieta humana. Estudios anteriores han demostrado que CGA juega un papel protector [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=33144","article_published_time":"2019-11-06T03:30:06+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/--LcqcIw1uYs\/Xb7b0CLZQ2I\/AAAAAAAAYSo\/S7tjwGlb5-8mcQWX2u_8DUGkJA3I1k-wQCLcBGAsYHQ\/s1600\/Anticancer_drugs.png"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\u00bb","datePublished":"2019-11-06T03:30:06+00:00","dateModified":"2019-11-06T03:30:06+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144"},"wordCount":404,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=33144#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144","url":"https:\/\/rina.naturopatiadigital.eu\/?p=33144","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2019-11-06T03:30:06+00:00","dateModified":"2019-11-06T03:30:06+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=33144"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33144#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl \u00e1cido clorog\u00e9nico induce la generaci\u00f3n reactiva de especies de ox\u00edgeno e inhibe la viabilidad de las c\u00e9lulas de c\u00e1ncer de colon humano\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/33144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33144"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/33144\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}