{"id":33147,"date":"2019-11-06T06:30:26","date_gmt":"2019-11-06T04:30:26","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33147"},"modified":"2019-11-06T06:30:26","modified_gmt":"2019-11-06T04:30:26","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-inhibe-la-invasion-y-metastasis-del-cancer-de-pulmon-al-atenuar-la-via-glut1-mt1-mmp-mmp2","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33147","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina inhibe la invasi\u00f3n y met\u00e1stasis del c\u00e1ncer de pulm\u00f3n al atenuar la v\u00eda GLUT1 \/ MT1-MMP \/ MMP2\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-C_qgNHYgxTg\/Xb7mujOpBTI\/AAAAAAAAYS0\/6o5Nf9BERUY9SWRdFPiziLf9GEGvm7ocgCLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BClinical%2Band%2BExperimental%2BMedicine.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-C_qgNHYgxTg\/Xb7mujOpBTI\/AAAAAAAAYS0\/6o5Nf9BERUY9SWRdFPiziLf9GEGvm7ocgCLcBGAsYHQ\/s320\/International_Journal%2Bof%2BClinical%2Band%2BExperimental%2BMedicine.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"250\" data-original-height=\"333\" \/><\/a>Liao, H., Wang, Z., Deng, Z., Ren, H., &amp; Li, X. (2015).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4538170\/\">Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1\/MT1-MMP\/MMP2 pathway<\/a>.\u00a0<i>International journal of clinical and experimental medicine<\/i>, 8(6), 8948.<\/p>\n<p>FONDO: El transportador de glucosa (GLUT) 1 se encuentra altamente expresado en tumores malignos y se considera un mediador que induce met\u00e1stasis de c\u00e1ncer. La curcumina es un producto natural que ejerce efectos antiinvasi\u00f3n y met\u00e1stasis en el c\u00e1ncer.<\/p>\n<p>OBJETIVO: Este estudio tuvo como objetivo evaluar si atenuar GLUT1 estaba involucrado en los efectos antiinvasi\u00f3n y met\u00e1stasis de la curcumina.<\/p>\n<p>M\u00c9TODO: En la parte in vitro , el vector pcDNA3.1-GLUT1 restringido se transfect\u00f3 en c\u00e9lulas A549. El ensayo MTT se us\u00f3 para evaluar los efectos de la curcumina sobre la proliferaci\u00f3n en las c\u00e9lulas A549 de c\u00e1ncer de pulm\u00f3n. El ensayo Transwell se us\u00f3 para evaluar el efecto antiinvasi\u00f3n de la curcumina en las c\u00e9lulas A549. La PCR en tiempo real y la transferencia Western se emplearon para examinar los niveles de expresi\u00f3n de GLUT1, membrana tipo 1-MMP (MT1-MMP) y metaloproteinasa de matriz (MMP) 2 en c\u00e9lulas A549 incubadas con curcumina. En la parte in vivo, el peso del tumor y la tasa metast\u00e1sica se evaluaron en ratones desnudos que ten\u00edan tumores sin transfectar, transfectados con vector vac\u00edo y c\u00e9lulas A549 transfectadas con pcDNA3.1-GLUT1.<\/p>\n<p>RESULTADOS: En este estudio, encontramos que la curcumina comenz\u00f3 a mostrar una citotoxicidad significativa contra el efecto de proliferaci\u00f3n a 45 \u03bcmol \/ L. La curcumina inhibi\u00f3 la invasi\u00f3n y las expresiones de las c\u00e9lulas A549 no transfectadas GLUT1, MT1-MMP y MMP2 de forma dependiente de la concentraci\u00f3n. Las c\u00e9lulas A549 transfectadas con pcDNA3.1-GLUT1 exhibieron resistencia al efecto anti-invasi\u00f3n de la curcumina al regular las expresiones de GLUT2, MT1-MMP y MMP2. Adem\u00e1s, la curcumina no logr\u00f3 disminuir la tasa metast\u00e1sica en ratones desnudos con c\u00e9lulas A549 transfectadas con pcDNA3.1-GLUT1 originadas en tumores.<\/p>\n<p>CONCLUSIONES: Estos resultados sugieren que la curcumina inhibe la invasi\u00f3n y met\u00e1stasis del c\u00e1ncer de pulm\u00f3n al atenuar la v\u00eda GLUT1 \/ MT1-MMP \/ MMP2.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liao, H., Wang, Z., Deng, Z., Ren, H., &amp; Li, X. (2015).\u00a0Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1\/MT1-MMP\/MMP2 pathway.\u00a0International journal of clinical and experimental medicine, 8(6), 8948. FONDO: El transportador de glucosa (GLUT) 1 se encuentra altamente expresado en tumores malignos y se considera un mediador que induce met\u00e1stasis de c\u00e1ncer. La [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33147","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la invasi\u00f3n y met\u00e1stasis del c\u00e1ncer de pulm\u00f3n al atenuar la v\u00eda GLUT1 \/ MT1-MMP \/ MMP2&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33147\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la invasi\u00f3n y met\u00e1stasis del c\u00e1ncer de pulm\u00f3n al atenuar la v\u00eda GLUT1 \/ MT1-MMP \/ MMP2&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liao, H., Wang, Z., Deng, Z., Ren, H., &amp; Li, X. (2015).\u00a0Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1\/MT1-MMP\/MMP2 pathway.\u00a0International journal of clinical and experimental medicine, 8(6), 8948. FONDO: El transportador de glucosa (GLUT) 1 se encuentra altamente expresado en tumores malignos y se considera un mediador que induce met\u00e1stasis de c\u00e1ncer. La [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33147\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T04:30:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-C_qgNHYgxTg\/Xb7mujOpBTI\/AAAAAAAAYS0\/6o5Nf9BERUY9SWRdFPiziLf9GEGvm7ocgCLcBGAsYHQ\/s320\/International_Journal%2Bof%2BClinical%2Band%2BExperimental%2BMedicine.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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