{"id":33153,"date":"2019-11-07T01:30:00","date_gmt":"2019-11-06T23:30:00","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33153"},"modified":"2019-11-07T01:30:00","modified_gmt":"2019-11-06T23:30:00","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-baicaleina-inhibe-la-invasion-y-las-capacidades-metastasicas-de-las-celulas-de-carcinoma-hepatocelular-mediante-la-regulacio","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33153","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa baicale\u00edna inhibe la invasi\u00f3n y las capacidades metast\u00e1sicas de las c\u00e9lulas de carcinoma hepatocelular mediante la regulaci\u00f3n negativa de la v\u00eda ERK\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-MjkDbT-f_aM\/Xb7p8UtpqJI\/AAAAAAAAYTI\/MAOEJ-0ekRIoavShUX12XsbyzQMsNW4gwCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-MjkDbT-f_aM\/Xb7p8UtpqJI\/AAAAAAAAYTI\/MAOEJ-0ekRIoavShUX12XsbyzQMsNW4gwCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\" border=\"0\" data-original-width=\"262\" data-original-height=\"317\" \/><\/a>Chen, K., Zhang, S., Ji, Y., Li, J., An, P., Ren, H., &#8230; &amp; Li, Z. (2013).\u00a0<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0072927\">Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway<\/a>.\u00a0<i>PLoS One<\/i>, 8(9), e72927.<\/p>\n<p>CONTEXTO: La baicale\u00edna, una medicina herbal china ampliamente utilizada, se ha utilizado hist\u00f3ricamente en terapias antiinflamatorias y anticancer\u00edgenas. Sin embargo, el efecto antimetast\u00e1sico y los mecanismos moleculares de la baicale\u00edna sobre el carcinoma hepatocelular (CHC) siguen siendo poco conocidos.\u00a0<\/p>\n<p>OBJETIVO: Por lo tanto, el prop\u00f3sito de este estudio fue evaluar los efectos antimetast\u00e1sicos de la baicale\u00edna y los mecanismos relacionados en el CHC.\u00a0<\/p>\n<p>M\u00c9TODO \/ RESULTADOS: En base a los ensayos utilizados en las l\u00edneas celulares de HCC y en un modelo animal, encontramos que la baicale\u00edna inhibi\u00f3 la met\u00e1stasis de las c\u00e9lulas tumorales in vivo e in vitro.. Adem\u00e1s, despu\u00e9s del tratamiento con baicale\u00edna durante 24 horas, hubo una disminuci\u00f3n en los niveles de metaloproteinasa de matriz 2 (MMP-2), MMP-9 y expresi\u00f3n del activador de plasmin\u00f3geno de tipo uroquinasa (u-PA), as\u00ed como la actividad de proteinasa en hepatocelular c\u00e9lulas de carcinoma MHCC97H. Mientras tanto, la expresi\u00f3n de inhibidor tisular de metaloproteinasa-1 (TIMP-1) y TIMP-2 se incrementaron de forma dependiente de la dosis. Adem\u00e1s, el tratamiento con baicale\u00edna disminuy\u00f3 dr\u00e1sticamente los niveles de las formas fosforiladas de MEK1 y ERK1 \/ 2. La sobreexpresi\u00f3n de MEK1 bloque\u00f3 parcialmente los efectos antimetast\u00e1sicos de la baicale\u00edna. El tratamiento combinado con un inhibidor de ERK (U0126) y baicale\u00edna dio como resultado una reducci\u00f3n sin\u00e9rgica en la expresi\u00f3n de MMP-2, MMP-9 y u-PA y un aumento en la expresi\u00f3n de TIMP-1 y TIMP-2; Tambi\u00e9n se inhibieron las capacidades invasivas de las c\u00e9lulas MHCC97H.\u00a0<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, la baicale\u00edna inhibe la invasi\u00f3n de las c\u00e9lulas tumorales y la met\u00e1stasis al reducir la motilidad celular y la migraci\u00f3n a trav\u00e9s de la supresi\u00f3n de la v\u00eda ERK, lo que sugiere que la baicale\u00edna es un agente terap\u00e9utico potencial para el CHC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chen, K., Zhang, S., Ji, Y., Li, J., An, P., Ren, H., &#8230; &amp; Li, Z. (2013).\u00a0Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway.\u00a0PLoS One, 8(9), e72927. CONTEXTO: La baicale\u00edna, una medicina herbal china ampliamente utilizada, se ha utilizado hist\u00f3ricamente en terapias antiinflamatorias y anticancer\u00edgenas. Sin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33153","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La baicale\u00edna inhibe la invasi\u00f3n y las capacidades metast\u00e1sicas de las c\u00e9lulas de carcinoma hepatocelular mediante la regulaci\u00f3n negativa de la v\u00eda ERK&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33153\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La baicale\u00edna inhibe la invasi\u00f3n y las capacidades metast\u00e1sicas de las c\u00e9lulas de carcinoma hepatocelular mediante la regulaci\u00f3n negativa de la v\u00eda ERK&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chen, K., Zhang, S., Ji, Y., Li, J., An, P., Ren, H., &#8230; &amp; Li, Z. (2013).\u00a0Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway.\u00a0PLoS One, 8(9), e72927. CONTEXTO: La baicale\u00edna, una medicina herbal china ampliamente utilizada, se ha utilizado hist\u00f3ricamente en terapias antiinflamatorias y anticancer\u00edgenas. Sin [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33153\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-06T23:30:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-MjkDbT-f_aM\/Xb7p8UtpqJI\/AAAAAAAAYTI\/MAOEJ-0ekRIoavShUX12XsbyzQMsNW4gwCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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