{"id":33159,"date":"2019-11-07T03:30:04","date_gmt":"2019-11-07T01:30:04","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33159"},"modified":"2019-11-07T03:30:04","modified_gmt":"2019-11-07T01:30:04","slug":"33159","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33159","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina suprime la met\u00e1stasis a trav\u00e9s de Sp-1, la inhibici\u00f3n de FAK y la regulaci\u00f3n de E-cadherina en el c\u00e1ncer colorrectal\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-rpKnjGeRCkE\/Xb7swockYxI\/AAAAAAAAYTY\/T48eSRyXsjUi4x5y-OeS9rQ1YghNQudBwCLcBGAsYHQ\/s1600\/Evidence_Based_Complmentary_Alternative_Medicine.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-rpKnjGeRCkE\/Xb7swockYxI\/AAAAAAAAYTY\/T48eSRyXsjUi4x5y-OeS9rQ1YghNQudBwCLcBGAsYHQ\/s320\/Evidence_Based_Complmentary_Alternative_Medicine.jpg\" width=\"253\" height=\"320\" border=\"0\" data-original-width=\"636\" data-original-height=\"803\" \/><\/a>Chen, C. C., Sureshbabul, M., Chen, H. W., Lin, Y. S., Lee, J. Y., Hong, Q. S., &#8230; &amp; Yu, S. L. (2013).\u00a0<a href=\"http:\/\/downloads.hindawi.com\/journals\/ecam\/2013\/541695.pdf\">Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-cadherin upregulation in colorectal cancer<\/a>.\u00a0<i>Evidence-Based Complementary and Alternative Medicine<\/i>, 2013.<\/p>\n<p>El c\u00e1ncer colorrectal (CCR) es un grave problema de salud p\u00fablica que se debe a cambios en la dieta y a diversos factores de estr\u00e9s ambiental en el mundo. La curcumina es una medicina tradicional utilizada para el tratamiento de una amplia variedad de tumores. Sin embargo, el mecanismo antimetastasis de la curcumina en CCR a\u00fan no se ha investigado por completo.\u00a0<\/p>\n<div>Aqu\u00ed, exploramos los mecanismos moleculares subyacentes de la curcumina en la met\u00e1stasis de las c\u00e9lulas CRC in vitro e in vivo.\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>La curcumina inhibe significativamente la migraci\u00f3n celular, la invasi\u00f3n y la formaci\u00f3n de colonias in vitro y reduce el crecimiento tumoral y la met\u00e1stasis hep\u00e1tica in vivo. Descubrimos que la curcumina suprime la actividad transcripcional de Sp-1 y los genes regulados por Sp-1, incluidos ADEM10, calmodulina, EPHB2, HDAC4 y SEPP1 en c\u00e9lulas CRC. La curcumina inhibe la fosforilaci\u00f3n de la quinasa de adhesi\u00f3n focal (FAK) y mejora las expresiones de varios componentes de la matriz extracelular que juegan un papel cr\u00edtico en la invasi\u00f3n y la met\u00e1stasis. La curcumina reduce la expresi\u00f3n de CD24 de una manera dependiente de la dosis en c\u00e9lulas CRC. Adem\u00e1s, la expresi\u00f3n de E-cadherina est\u00e1 regulada por la curcumina y sirve como inhibidor de EMT.\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>Estos resultados sugieren que la curcumina ejecuta su funci\u00f3n antimetastasis a trav\u00e9s de la regulaci\u00f3n negativa de Sp-1, FAK y CD24 y promoviendo la expresi\u00f3n de E-cadherina en c\u00e9lulas CRC.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Chen, C. C., Sureshbabul, M., Chen, H. W., Lin, Y. S., Lee, J. Y., Hong, Q. S., &#8230; &amp; Yu, S. L. (2013).\u00a0Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-cadherin upregulation in colorectal cancer.\u00a0Evidence-Based Complementary and Alternative Medicine, 2013. El c\u00e1ncer colorrectal (CCR) es un grave problema de salud p\u00fablica que se debe a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33159","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime la met\u00e1stasis a trav\u00e9s de Sp-1, la inhibici\u00f3n de FAK y la regulaci\u00f3n de E-cadherina en el c\u00e1ncer colorrectal&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33159\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime la met\u00e1stasis a trav\u00e9s de Sp-1, la inhibici\u00f3n de FAK y la regulaci\u00f3n de E-cadherina en el c\u00e1ncer colorrectal&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chen, C. C., Sureshbabul, M., Chen, H. W., Lin, Y. S., Lee, J. Y., Hong, Q. S., &#8230; &amp; Yu, S. L. (2013).\u00a0Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-cadherin upregulation in colorectal cancer.\u00a0Evidence-Based Complementary and Alternative Medicine, 2013. 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