{"id":33163,"date":"2019-11-07T04:30:49","date_gmt":"2019-11-07T02:30:49","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33163"},"modified":"2019-11-07T04:30:49","modified_gmt":"2019-11-07T02:30:49","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-suprime-el-crecimiento-de-celulas-tumorales-gastricas-a-traves-del-agotamiento-de-la-adn-polimerasa-%ce%b3-mediada","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33163","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina suprime el crecimiento de c\u00e9lulas tumorales g\u00e1stricas a trav\u00e9s del agotamiento de la ADN polimerasa \u03b3 mediada por ROS que interrumpe la bioenerg\u00e9tica celular\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-S4UoH2rg5pk\/Xb7uGGDQuHI\/AAAAAAAAYTg\/93bEKuwtoSAsowxB-LIfMEB33u6pXZh5ACLcBGAsYHQ\/s1600\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-S4UoH2rg5pk\/Xb7uGGDQuHI\/AAAAAAAAYTg\/93bEKuwtoSAsowxB-LIfMEB33u6pXZh5ACLcBGAsYHQ\/s320\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg\" width=\"225\" height=\"320\" border=\"0\" data-original-width=\"306\" data-original-height=\"434\" \/><\/a>Wang, L., Chen, X., Du, Z., Li, G., Chen, M., Chen, X., &#8230; &amp; Chen, T. (2017).\u00a0<a href=\"https:\/\/jeccr.biomedcentral.com\/articles\/10.1186\/s13046-017-0513-5\">Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase \u03b3 depletion disrupting cellular bioenergetics.<\/a>\u00a0<i>Journal of Experimental &amp; Clinical Cancer Research<\/i>, 36(1), 47.<\/p>\n<p>ANTECEDENTES: La curcumina, como agente proapopt\u00f3tico, se estudia ampliamente para inhibir el crecimiento de c\u00e9lulas tumorales de varios tipos de tumores. El trabajo previo ha demostrado que la curcumina inhibe el crecimiento de c\u00e9lulas cancerosas al enfocarse en la transducci\u00f3n de se\u00f1alizaci\u00f3n m\u00faltiple y los procesos celulares. Sin embargo, el papel de la curcumina en la regulaci\u00f3n de los procesos bioenerg\u00e9ticos celulares sigue siendo en gran medida desconocido.<\/p>\n<p>M\u00c9TODOS: Se realizaron transferencias Western y qRT-PCR para analizar el nivel de prote\u00edna y ARNm de las mol\u00e9culas indicadas, respectivamente. Se utilizaron RTCA, ensayo CCK-8, ensayo de xenoinjerto de ratones desnudos y obtenci\u00f3n de im\u00e1genes de bioluminiscencia in vivo para visualizar los efectos de la curcmina en el crecimiento de c\u00e9lulas de c\u00e1ncer g\u00e1strico in vitro e in vivo. El analizador de bioenerg\u00e9tica Seahorse se utiliz\u00f3 para investigar la alteraci\u00f3n del consumo de ox\u00edgeno y la tasa de gluc\u00f3lisis aer\u00f3bica.<\/p>\n<p>RESULTADOS: La curcumina inhibi\u00f3 significativamente el crecimiento de c\u00e9lulas tumorales g\u00e1stricas, la proliferaci\u00f3n y la formaci\u00f3n de colonias. Investigamos a\u00fan m\u00e1s el papel de la curcumina en la regulaci\u00f3n de la homeostasis redox celular y demostramos que la curcumina inici\u00f3 una apoptosis celular severa al interrumpir la homeostasis mitocondrial, lo que mejora el estr\u00e9s oxidativo celular en las c\u00e9lulas de c\u00e1ncer g\u00e1strico. Adem\u00e1s, la curcumina disminuy\u00f3 dr\u00e1sticamente el contenido de ADNmt y la ADN polimerasa \u03b3 (POLG), lo que contribuy\u00f3 a reducir el consumo de ox\u00edgeno mitocondrial y la gluc\u00f3lisis aer\u00f3bica. Descubrimos que la curcumina indujo el agotamiento de POLG a trav\u00e9s de la generaci\u00f3n de ROS, y la eliminaci\u00f3n de POLG tambi\u00e9n redujo la actividad de fosforilaci\u00f3n oxidativa (OXPHOS) y la tasa de glucol\u00edtica celular que fue parcialmente rescatada por el eliminador de ROS NAC, la POLG nativa desempe\u00f1a un papel importante en el tratamiento del c\u00e1ncer g\u00e1strico. Los datos en el modelo de ratones desnudos verificaron que el tratamiento con curcumina atenu\u00f3 significativamente el crecimiento tumoral in vivo. Finalmente, el POLG estaba regulado por aumento en los tejidos de c\u00e1ncer g\u00e1strico humano y el crecimiento celular primario del c\u00e1ncer g\u00e1strico se suprimi\u00f3 notablemente debido a la deficiencia de POLG.<\/p>\n<p>CONCLUSIONES: Juntos, nuestros datos sugieren un nuevo mecanismo por el cual la curcumina inhibi\u00f3 el crecimiento del tumor g\u00e1strico a trav\u00e9s de la generaci\u00f3n excesiva de ROS, lo que resulta en el agotamiento de POLG y ADNmt, y la posterior interrupci\u00f3n de la bioenerg\u00e9tica celular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang, L., Chen, X., Du, Z., Li, G., Chen, M., Chen, X., &#8230; &amp; Chen, T. (2017).\u00a0Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase \u03b3 depletion disrupting cellular bioenergetics.\u00a0Journal of Experimental &amp; Clinical Cancer Research, 36(1), 47. ANTECEDENTES: La curcumina, como agente proapopt\u00f3tico, se estudia ampliamente para inhibir el crecimiento de c\u00e9lulas tumorales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33163","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime el crecimiento de c\u00e9lulas tumorales g\u00e1stricas a trav\u00e9s del agotamiento de la ADN polimerasa \u03b3 mediada por ROS que interrumpe la bioenerg\u00e9tica celular&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33163\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime el crecimiento de c\u00e9lulas tumorales g\u00e1stricas a trav\u00e9s del agotamiento de la ADN polimerasa \u03b3 mediada por ROS que interrumpe la bioenerg\u00e9tica celular&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wang, L., Chen, X., Du, Z., Li, G., Chen, M., Chen, X., &#8230; &amp; Chen, T. (2017).\u00a0Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase \u03b3 depletion disrupting cellular bioenergetics.\u00a0Journal of Experimental &amp; Clinical Cancer Research, 36(1), 47. 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tumorales g\u00e1stricas a trav\u00e9s del agotamiento de la ADN polimerasa \u03b3 mediada por ROS que interrumpe la bioenerg\u00e9tica celular\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=33163","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina suprime el crecimiento de c\u00e9lulas tumorales g\u00e1stricas a trav\u00e9s del agotamiento de la ADN polimerasa \u03b3 mediada por ROS que interrumpe la bioenerg\u00e9tica celular\" -","og_description":"Wang, L., Chen, X., Du, Z., Li, G., Chen, M., Chen, X., &#8230; &amp; Chen, T. 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ANTECEDENTES: La curcumina, como agente proapopt\u00f3tico, se estudia ampliamente para inhibir el crecimiento de c\u00e9lulas tumorales [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=33163","article_published_time":"2019-11-07T02:30:49+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-S4UoH2rg5pk\/Xb7uGGDQuHI\/AAAAAAAAYTg\/93bEKuwtoSAsowxB-LIfMEB33u6pXZh5ACLcBGAsYHQ\/s320\/Journal_Experimental%2B%2526%2BClinical%2BCancer%2BResearch.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33163#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=33163"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias 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