{"id":33423,"date":"2019-11-13T04:30:40","date_gmt":"2019-11-13T02:30:40","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33423"},"modified":"2019-11-13T04:30:40","modified_gmt":"2019-11-13T02:30:40","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-ensayo-clinico-de-fase-i-de-la-curcumina-un-agente-quimiopreventivo-en-pacientes-con-lesiones-de-alto-riesgo-o-premalignas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33423","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEnsayo cl\u00ednico de fase I de la curcumina, un agente quimiopreventivo, en pacientes con lesiones de alto riesgo o premalignas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-kZA4-hSWKaw\/XcwyaazyGfI\/AAAAAAAAYdM\/bO48tesbvQkprWyqrI53E9TP2tlzXJxVACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-kZA4-hSWKaw\/XcwyaazyGfI\/AAAAAAAAYdM\/bO48tesbvQkprWyqrI53E9TP2tlzXJxVACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\" border=\"0\" data-original-width=\"192\" data-original-height=\"263\" \/><\/a>Hsieh, C. Y. (2001).\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Chih-Hung_Hsu\/publication\/11642081_Phase_I_clinical_trial_of_curcumin_a_chemopreventive_agent_in_patients_with_high-risk_or_pre-malignant_lesions\/links\/0c960529f48efaeebc000000.pdf\">Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions<\/a>.<i>\u00a0Anticancer Res<\/i>, 21(2895), e2900.<\/p>\n<p>CONTEXTO: Se ha demostrado que la curcumina (diferuloilmetano), una sustancia amarilla de la ra\u00edz de la planta Curcuma longa Linn., inhibe la carcinog\u00e9nesis de la piel, el est\u00f3mago, el intestino y el h\u00edgado murinos. Sin embargo, no se ha informado la toxicolog\u00eda, la farmacocin\u00e9tica y la dosis biol\u00f3gicamente efectiva de curcumina en humanos.\u00a0<\/p>\n<p>OBJETIVO: Este estudio prospectivo de fase I evalu\u00f3 estos problemas de curcumina en pacientes con una de las siguientes cinco condiciones de alto riesgo: 1) c\u00e1ncer de vejiga urinaria resecado recientemente; 2) enfermedad de Bowen por ars\u00e9nico de la piel; 3) neoplasia intraepitelial cervical uterina (CIN); 4) leucoplaquia oral; y 5) metaplasia intestinal del est\u00f3mago.\u00a0<\/p>\n<p>PARTICIPANTES \/ M\u00c9TODO \/ MEDIDAS DE RESULTADOS: La curcumina se tom\u00f3 por v\u00eda oral durante 3 meses. La biopsia de los sitios de la lesi\u00f3n se realiz\u00f3 inmediatamente antes y 3 meses despu\u00e9s de comenzar el tratamiento con curcumina. La dosis inicial fue de 500 mg \/ d\u00eda. Si no hay toxicidad&gt; o = se observ\u00f3 grado II en al menos 3 pacientes sucesivos, la dosis se escal\u00f3 a otro nivel del orden de 1,000, 2,000, 4,000, 8,000 y 12,000 mg \/ d\u00eda. La concentraci\u00f3n de curcumina en suero y orina se determin\u00f3 por cromatograf\u00eda l\u00edquida de alta presi\u00f3n (HPLC). Un total de 25 pacientes se inscribieron en este estudio. No hubo toxicidad relacionada con el tratamiento hasta 8,000 mg \/ d\u00eda. M\u00e1s all\u00e1 de 8,000 mg \/ d\u00eda, el volumen voluminoso de la droga era inaceptable para los pacientes. La concentraci\u00f3n s\u00e9rica de curcumina generalmente alcanz\u00f3 su punto m\u00e1ximo de 1 a 2 horas despu\u00e9s de la ingesta oral de crucuminio y disminuy\u00f3 gradualmente en 12 horas. Las concentraciones s\u00e9ricas m\u00e1ximas promedio despu\u00e9s de tomar 4,000 mg, 6,000 mg y 8,000 mg de curcumina fueron 0.51 +\/- 0.11 microM, 0.63 +\/- 0.06 microM y 1.77 +\/- 1.87 microM, respectivamente. La excreci\u00f3n urinaria de curcumina fue indetectable.\u00a0<\/p>\n<p>RESULTADOS: Uno de 4 pacientes con CIN y 1 de 7 pacientes con leucoplaquia oral procedieron a desarrollar neoplasias malignas a pesar del tratamiento con curcumina. Por el contrario, se observ\u00f3 una mejor\u00eda histol\u00f3gica de las lesiones precancerosas en 1 de cada 2 pacientes con c\u00e1ncer de vejiga recientemente resecado, 2 de cada 7 pacientes con leucoplaquia oral, 1 de cada 6 pacientes con metaplasia intestinal del est\u00f3mago, I de cada 4 pacientes con CIN y 2 de cada 6 pacientes con enfermedad de Bowen. En conclusi\u00f3n, este estudio demostr\u00f3 que la curcumina no es t\u00f3xica para los humanos hasta 8,000 mg \/ d\u00eda cuando se toma por v\u00eda oral durante 3 meses.\u00a0<\/p>\n<p>CONCLUSIONES: Nuestros resultados tambi\u00e9n sugieren un efecto biol\u00f3gico de la curcumina en la quimioprevenci\u00f3n del c\u00e1ncer. Se observ\u00f3 una mejor\u00eda histol\u00f3gica de las lesiones precancerosas en 1 de cada 2 pacientes con c\u00e1ncer de vejiga recientemente resecado, 2 de cada 7 pacientes con leucoplaquia oral, 1 de cada 6 pacientes con metaplasia intestinal del est\u00f3mago, 1 de cada 4 pacientes con CIN y 2 de cada de 6 pacientes con enfermedad de Bowen.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hsieh, C. Y. (2001).\u00a0Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.\u00a0Anticancer Res, 21(2895), e2900. CONTEXTO: Se ha demostrado que la curcumina (diferuloilmetano), una sustancia amarilla de la ra\u00edz de la planta Curcuma longa Linn., inhibe la carcinog\u00e9nesis de la piel, el est\u00f3mago, el intestino y el h\u00edgado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33423","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Ensayo cl\u00ednico de fase I de la curcumina, un agente quimiopreventivo, en pacientes con lesiones de alto riesgo o premalignas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33423\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Ensayo cl\u00ednico de fase I de la curcumina, un agente quimiopreventivo, en pacientes con lesiones de alto riesgo o premalignas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hsieh, C. Y. (2001).\u00a0Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.\u00a0Anticancer Res, 21(2895), e2900. CONTEXTO: Se ha demostrado que la curcumina (diferuloilmetano), una sustancia amarilla de la ra\u00edz de la planta Curcuma longa Linn., inhibe la carcinog\u00e9nesis de la piel, el est\u00f3mago, el intestino y el h\u00edgado [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33423\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-13T02:30:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-kZA4-hSWKaw\/XcwyaazyGfI\/AAAAAAAAYdM\/bO48tesbvQkprWyqrI53E9TP2tlzXJxVACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" 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