{"id":33426,"date":"2019-11-13T05:30:38","date_gmt":"2019-11-13T03:30:38","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33426"},"modified":"2019-11-13T05:30:38","modified_gmt":"2019-11-13T03:30:38","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-papel-del-resveratrol-en-la-prevencion-y-terapia-del-cancer-estudios-preclinicos-y-clinicos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33426","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPapel del resveratrol en la prevenci\u00f3n y terapia del c\u00e1ncer: estudios precl\u00ednicos y cl\u00ednicos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-kZA4-hSWKaw\/XcwyaazyGfI\/AAAAAAAAYdM\/bO48tesbvQkprWyqrI53E9TP2tlzXJxVACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-kZA4-hSWKaw\/XcwyaazyGfI\/AAAAAAAAYdM\/bO48tesbvQkprWyqrI53E9TP2tlzXJxVACLcBGAsYHQ\/s1600\/Anticancer_Research.jpg\" border=\"0\" data-original-width=\"192\" data-original-height=\"263\" \/><\/a>Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., &amp; Takada, Y. (2004).\u00a0<a href=\"http:\/\/ar.iiarjournals.org\/content\/24\/5A\/2783.full.pdf\">Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studie<\/a>s.\u00a0<i>Anticancer research<\/i>, 24(5A), 2783-2840.<\/p>\n<p>El resveratrol, trans-3,5,4&#8242;-trihidroxiestilbeno, se aisl\u00f3 por primera vez en 1940 como un componente de las ra\u00edces del el\u00e9boro blanco (Veratrum grandiflorum O. Loes), pero desde entonces se ha encontrado en varias plantas, incluidas las uvas, las bayas y los cacahuetes. Adem\u00e1s de los efectos cardioprotectores, el resveratrol exhibe propiedades anticancer\u00edgenas, como lo sugiere su capacidad para suprimir la proliferaci\u00f3n de una amplia variedad de c\u00e9lulas tumorales, incluidos los c\u00e1nceres linfoides y mieloides; mieloma m\u00faltiple; c\u00e1nceres de mama, pr\u00f3stata, est\u00f3mago, colon, p\u00e1ncreas y tiroides; melanoma; carcinoma de c\u00e9lulas escamosas de cabeza y cuello; carcinoma de ovario; y carcinoma cervical.\u00a0<\/p>\n<p>Los efectos inhibidores del crecimiento del resveratrol est\u00e1n mediados por la detenci\u00f3n del ciclo celular; regulaci\u00f3n positiva de p21Cip1 \/ WAF1, p53 y Bax; regulaci\u00f3n por disminuci\u00f3n de survivina, ciclina D1, ciclina E, Bcl-2, Bcl-xL y clAPs; y activaci\u00f3n de caspasas. Se ha demostrado que el resveratrol suprime la activaci\u00f3n de varios factores de transcripci\u00f3n, incluidos NF-kappaB, AP-1 y Egr-1; para inhibir las prote\u00ednas quinasas que incluyen IkappaBalpha quinasa, JNK, MAPK, Akt, PKC, PKD y case\u00edna quinasa II; y para regular a la baja productos de genes tales como COX-2, 5-LOX, VEGF, IL-1, IL-6, IL-8, AR y PSA.\u00a0<\/p>\n<p>Estas actividades explican la supresi\u00f3n de la angiog\u00e9nesis por este estilbeno. Tambi\u00e9n se ha demostrado que el resveratrol potencia los efectos apopt\u00f3ticos de las citocinas (por ejemplo, TRAIL), agentes quimioterap\u00e9uticos y radiaci\u00f3n gamma.\u00a0<\/p>\n<p>Los estudios famacocin\u00e9ticos revelaron que los \u00f3rganos diana del resveratrol son el h\u00edgado y el ri\u00f1\u00f3n, donde se concentra despu\u00e9s de la absorci\u00f3n y se convierte principalmente en una forma sulfatada y un conjugado de glucur\u00f3nido. In vivo, el resveratrol bloquea el proceso de m\u00faltiples etapas de la carcinog\u00e9nesis en varias etapas: bloquea la activaci\u00f3n del carcin\u00f3geno al inhibir la expresi\u00f3n y actividad de CYP1A1 inducida por hidrocarburos de arilo, y suprime la iniciaci\u00f3n, promoci\u00f3n y progresi\u00f3n del tumor. Adem\u00e1s de los efectos quimiopreventivos, el resveratrol parece exhibir efectos terap\u00e9uticos contra el c\u00e1ncer.\u00a0<\/p>\n<p>Datos limitados en humanos han revelado que el resveratrol es farmacol\u00f3gicamente bastante seguro. Actualmente, los an\u00e1logos estructurales del resveratrol con biodisponibilidad mejorada se est\u00e1n buscando como agentes terap\u00e9uticos potenciales para el c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., &amp; Takada, Y. (2004).\u00a0Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.\u00a0Anticancer research, 24(5A), 2783-2840. El resveratrol, trans-3,5,4&#8242;-trihidroxiestilbeno, se aisl\u00f3 por primera vez en 1940 como un componente de las ra\u00edces del el\u00e9boro blanco (Veratrum grandiflorum O. Loes), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33426","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Papel del resveratrol en la prevenci\u00f3n y terapia del c\u00e1ncer: estudios precl\u00ednicos y cl\u00ednicos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33426\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Papel del resveratrol en la prevenci\u00f3n y terapia del c\u00e1ncer: estudios precl\u00ednicos y cl\u00ednicos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., &amp; Takada, Y. (2004).\u00a0Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.\u00a0Anticancer research, 24(5A), 2783-2840. El resveratrol, trans-3,5,4&#8242;-trihidroxiestilbeno, se aisl\u00f3 por primera vez en 1940 como un componente de las ra\u00edces del el\u00e9boro blanco (Veratrum grandiflorum O. 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