{"id":33663,"date":"2019-11-20T01:30:58","date_gmt":"2019-11-19T23:30:58","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33663"},"modified":"2019-11-20T01:30:58","modified_gmt":"2019-11-19T23:30:58","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-flavonoide-eriodictyol-induce-proteccion-a-largo-plazo-en-las-celulas-arpe-19-a-traves-de-sus-efectos-sobre-la-activacion","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33663","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl flavonoide, eriodictyol, induce protecci\u00f3n a largo plazo en las c\u00e9lulas ARPE-19 a trav\u00e9s de sus efectos sobre la activaci\u00f3n de Nrf2 y la expresi\u00f3n g\u00e9nica de fase 2\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-31VEcUQ7HDw\/XdAquWsHE6I\/AAAAAAAAYnU\/eTx-NK63JGcurp6XsGbanGHvrILV8WIcQCLcBGAsYHQ\/s1600\/IOVS3.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-31VEcUQ7HDw\/XdAquWsHE6I\/AAAAAAAAYnU\/eTx-NK63JGcurp6XsGbanGHvrILV8WIcQCLcBGAsYHQ\/s1600\/IOVS3.gif\" border=\"0\" data-original-width=\"172\" data-original-height=\"220\" \/><\/a>Johnson, J., Maher, P., &amp; Hanneken, A. (2009).\u00a0<a href=\"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2126044\">The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression<\/a>.\u00a0<i>Investigative ophthalmology &amp; visual science<\/i>, 50(5), 2398-2406.<\/p>\n<p>PROP\u00d3SITO: Eriodictyol, un flavonoide que se encuentra en las frutas c\u00edtricas, se encuentra entre los compuestos m\u00e1s potentes que se informa que protegen las c\u00e9lulas RPE humanas de la muerte celular inducida por el estr\u00e9s oxidativo. El presente estudio busc\u00f3 determinar si la expresi\u00f3n de la prote\u00edna de fase 2 inducida por eriodictyol mejora a\u00fan m\u00e1s la resistencia de las c\u00e9lulas ARPE-19 humanas al estr\u00e9s oxidativo.<\/p>\n<p>M\u00c9TODOS: Se analiz\u00f3 la capacidad del eriodictyol para activar Nrf2 e inducir las prote\u00ednas de fase 2 hemooxigenasa (HO) -1 y NAD (P) H: quinona oxidorreductasa (NQO) -1 y el antioxidante celular glutati\u00f3n (GSH). Se realizaron ensayos de citoprotecci\u00f3n en c\u00e9lulas ARPE-19 que sobreexpresaban HO-1 o NQO-1, se compar\u00f3 la supervivencia celular despu\u00e9s del tratamiento con eriodictyol a corto y largo plazo, y se compar\u00f3 el mecanismo de protecci\u00f3n usando un Nrf2 negativo dominante y shRNA espec\u00edfico para HO -1 fue probado.<\/p>\n<p>RESULTADOS: Eriodictyol indujo la translocaci\u00f3n nuclear de Nrf2, mejor\u00f3 la expresi\u00f3n de HO-1 y NQO-1, y aument\u00f3 los niveles de glutati\u00f3n intracelular. Las c\u00e9lulas ARPE-19 que sobreexpresan HO-1 o NQO-1 fueron m\u00e1s resistentes a la muerte celular inducida por el estr\u00e9s oxidativo que las c\u00e9lulas de control. Eriodictyol indujo una protecci\u00f3n a largo plazo significativamente mayor que su protecci\u00f3n a corto plazo. Este efecto se correlacion\u00f3 temporalmente con la activaci\u00f3n de Nrf2 y la inducci\u00f3n de enzimas de fase 2 y podr\u00eda bloquearse con el uso de un Nrf2 negativo dominante y un shRNA espec\u00edfico para HO-1.<\/p>\n<p>CONCLUSIONES: Estos hallazgos indican que el mayor beneficio del eriodictyol puede ser su capacidad para regular la expresi\u00f3n g\u00e9nica y mejorar las defensas celulares m\u00faltiples frente a la lesi\u00f3n oxidativa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Johnson, J., Maher, P., &amp; Hanneken, A. (2009).\u00a0The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression.\u00a0Investigative ophthalmology &amp; visual science, 50(5), 2398-2406. PROP\u00d3SITO: Eriodictyol, un flavonoide que se encuentra en las frutas c\u00edtricas, se encuentra entre los compuestos m\u00e1s potentes que se informa que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-33663","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El flavonoide, eriodictyol, induce protecci\u00f3n a largo plazo en las c\u00e9lulas ARPE-19 a trav\u00e9s de sus efectos sobre la activaci\u00f3n de Nrf2 y la expresi\u00f3n g\u00e9nica de fase 2&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33663\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El flavonoide, eriodictyol, induce protecci\u00f3n a largo plazo en las c\u00e9lulas ARPE-19 a trav\u00e9s de sus efectos sobre la activaci\u00f3n de Nrf2 y la expresi\u00f3n g\u00e9nica de fase 2&quot; -\" \/>\n<meta property=\"og:description\" content=\"Johnson, J., Maher, P., &amp; Hanneken, A. (2009).\u00a0The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression.\u00a0Investigative ophthalmology &amp; visual science, 50(5), 2398-2406. PROP\u00d3SITO: Eriodictyol, un flavonoide que se encuentra en las frutas c\u00edtricas, se encuentra entre los compuestos m\u00e1s potentes que se informa que [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33663\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-19T23:30:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-31VEcUQ7HDw\/XdAquWsHE6I\/AAAAAAAAYnU\/eTx-NK63JGcurp6XsGbanGHvrILV8WIcQCLcBGAsYHQ\/s1600\/IOVS3.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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