{"id":33881,"date":"2019-11-26T01:30:15","date_gmt":"2019-11-26T00:30:15","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33881"},"modified":"2019-11-26T01:30:15","modified_gmt":"2019-11-26T00:30:15","slug":"area-de-conocimiento-naturopatia-descriptiva-estres-oxidativo-y-agregacion-de-proteinas-durante-el-envejecimiento-biologico","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33881","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEstr\u00e9s oxidativo y agregaci\u00f3n de prote\u00ednas durante el envejecimiento biol\u00f3gico\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-yDgt1VUyNfg\/Xd13KW2gmhI\/AAAAAAAAYvQ\/Z4mhL70uwHQA8ihDKOrnXxxfAwJYq9YhQCLcBGAsYHQ\/s1600\/Experimental_Gerontology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-yDgt1VUyNfg\/Xd13KW2gmhI\/AAAAAAAAYvQ\/Z4mhL70uwHQA8ihDKOrnXxxfAwJYq9YhQCLcBGAsYHQ\/s1600\/Experimental_Gerontology.jpg\" border=\"0\" data-original-width=\"198\" data-original-height=\"264\" \/><\/a>Squier, T. C. (2001).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11525876\">Oxidative stress and protein aggregation during biological aging<\/a>.\u00a0<i>Experimental gerontology<\/i>, 36(9), 1539-1550.<\/p>\n<p>El envejecimiento biol\u00f3gico es un proceso fundamental que representa el principal factor de riesgo con respecto al desarrollo de c\u00e1ncer, enfermedades neurodegenerativas y cardiovasculares en vertebrados. Por lo tanto, es evidente que los mecanismos moleculares del envejecimiento son fundamentales para comprender muchos procesos de enfermedad.<\/p>\n<p>A este respecto, se ha sugerido que la oxidaci\u00f3n y la nitraci\u00f3n de las prote\u00ednas intracelulares y la formaci\u00f3n de agregados de prote\u00ednas subyacen a la p\u00e9rdida de la funci\u00f3n celular y a la capacidad reducida de los animales senescentes para soportar tensiones fisiol\u00f3gicas.<\/p>\n<p>Dado que las prote\u00ednas oxidativamente modificadas son termodin\u00e1micamente inestables y suponen estructuras terciarias parcialmente desplegadas que forman f\u00e1cilmente agregados, es probable que las prote\u00ednas oxidadas sean intermedias en la formaci\u00f3n de fibrillas amiloides.<\/p>\n<p>Por lo tanto, es de inter\u00e9s para identificar los objetivos de prote\u00ednas sensibles a la oxidaci\u00f3n que pueden jugar un papel protector a trav\u00e9s de su capacidad para regular a la baja el metabolismo energ\u00e9tico y la consecuente generaci\u00f3n de especies reactivas de ox\u00edgeno (ROS).<\/p>\n<p>En este sentido, el mantenimiento de los gradientes de calcio celular representa un gran gasto energ\u00e9tico, que vincula las alteraciones en los niveles de calcio intracelular con la utilizaci\u00f3n de ATP y la generaci\u00f3n asociada de ROS a trav\u00e9s de mecanismos de control respiratorio.<\/p>\n<p>La oxidaci\u00f3n o nitraci\u00f3n selectiva de las prote\u00ednas reguladoras del calcio calmodulina y Ca-ATPasa que se produce in vivo durante el envejecimiento y bajo condiciones de estr\u00e9s oxidativo puede representar una respuesta adaptativa al estr\u00e9s oxidativo que funciona para regular negativamente el metabolismo energ\u00e9tico y la generaci\u00f3n asociada de ROS.<\/p>\n<p>Dado que estas prote\u00ednas reguladoras del calcio tambi\u00e9n se oxidan o nitran preferentemente en condiciones in vitro, estos resultados sugieren una sensibilidad mejorada de estas prote\u00ednas cr\u00edticas reguladoras del calcio, que modulan los procesos de transducci\u00f3n de se\u00f1ales y el metabolismo energ\u00e9tico intracelular, a condiciones de estr\u00e9s oxidativo.<\/p>\n<p>Por lo tanto, la oxidaci\u00f3n selectiva de las prote\u00ednas de transducci\u00f3n de se\u00f1ales cr\u00edticas probablemente represente un mecanismo regulador que funciona para minimizar la generaci\u00f3n de ROS a trav\u00e9s de mecanismos de control respiratorio.<\/p>\n<p>La reducci\u00f3n de la tasa de generaci\u00f3n de ROS, a su vez, promover\u00e1 la supervivencia celular en condiciones de estr\u00e9s oxidativo, cuando las especies reactivas de ox\u00edgeno y nitr\u00f3geno abruman los sistemas de defensa antioxidante celular, al minimizar la oxidaci\u00f3n no selectiva de una gama de biomol\u00e9culas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Squier, T. C. (2001).\u00a0Oxidative stress and protein aggregation during biological aging.\u00a0Experimental gerontology, 36(9), 1539-1550. El envejecimiento biol\u00f3gico es un proceso fundamental que representa el principal factor de riesgo con respecto al desarrollo de c\u00e1ncer, enfermedades neurodegenerativas y cardiovasculares en vertebrados. Por lo tanto, es evidente que los mecanismos moleculares del envejecimiento son fundamentales para comprender [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33881","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo y agregaci\u00f3n de prote\u00ednas durante el envejecimiento biol\u00f3gico&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33881\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Estr\u00e9s oxidativo y agregaci\u00f3n de prote\u00ednas durante el envejecimiento biol\u00f3gico&quot; -\" \/>\n<meta property=\"og:description\" content=\"Squier, T. C. (2001).\u00a0Oxidative stress and protein aggregation during biological aging.\u00a0Experimental gerontology, 36(9), 1539-1550. El envejecimiento biol\u00f3gico es un proceso fundamental que representa el principal factor de riesgo con respecto al desarrollo de c\u00e1ncer, enfermedades neurodegenerativas y cardiovasculares en vertebrados. Por lo tanto, es evidente que los mecanismos moleculares del envejecimiento son fundamentales para comprender [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33881\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-26T00:30:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-yDgt1VUyNfg\/Xd13KW2gmhI\/AAAAAAAAYvQ\/Z4mhL70uwHQA8ihDKOrnXxxfAwJYq9YhQCLcBGAsYHQ\/s1600\/Experimental_Gerontology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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