{"id":33883,"date":"2019-11-26T02:30:04","date_gmt":"2019-11-26T01:30:04","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33883"},"modified":"2019-11-26T02:30:04","modified_gmt":"2019-11-26T01:30:04","slug":"area-de-conocimiento-naturopatia-descriptiva-insuficiencia-catabolica-y-envejecimiento","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33883","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abInsuficiencia catab\u00f3lica y envejecimiento\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-ywWK_O1TgF0\/Xd14YI845CI\/AAAAAAAAYvY\/efiEYaA7KRUWh1A76R7DUNUxwju4iPqCgCLcBGAsYHQ\/s1600\/Annals_NewYork_Academic_Science2.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-ywWK_O1TgF0\/Xd14YI845CI\/AAAAAAAAYvY\/efiEYaA7KRUWh1A76R7DUNUxwju4iPqCgCLcBGAsYHQ\/s320\/Annals_NewYork_Academic_Science2.jpg\" width=\"224\" height=\"320\" border=\"0\" data-original-width=\"700\" data-original-height=\"1000\" \/><\/a>Terman, A. (2006).\u00a0<a href=\"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/abs\/10.1196\/annals.1354.005\">Catabolic insufficiency and aging<\/a>.\u00a0<i>Annals of the New York Academy of Sciences<\/i>, 1067(1), 27-36.\u00a0<\/p>\n<p>Los procesos degradativos celulares, que incluyen la degradaci\u00f3n lisosomal (autof\u00e1gica) y proteasomal, as\u00ed como la actividad de las proteasas citos\u00f3licas y mitocondriales, proporcionan una renovaci\u00f3n continua de biomol\u00e9culas y org\u00e1nulos da\u00f1ados y obsoletos.<\/p>\n<p>La insuficiencia inherente de estos procesos degradativos da como resultado una acumulaci\u00f3n progresiva dentro de c\u00e9lulas postmit\u00f3ticas de larga vida de \u00abbasura\u00bb biol\u00f3gica (material \u00abresidual\u00bb), como agregados de prote\u00ednas indigeribles, mitocondrias defectuosas y lipofuscina (pigmento de la edad), intraliosomal, polim\u00e9rico, no degradable material.\u00a0<\/p>\n<p>La \u00abbasura\u00bb intracelular no est\u00e1 completamente catabolizada ni exoc\u00edtica en grado considerable. Carga pesada de lipofuscina en los lisosomas, t\u00edpica de la vejez parece disminuir marcadamente el potencial autof\u00e1gico.\u00a0<\/p>\n<p>Como se postula en la teor\u00eda del envejecimiento mitocondrial-lisosomal, esto ocurre debido al transporte de enzimas lisosomales reci\u00e9n sintetizadas a lisosomas cargados de lipofuscina en lugar de a lisosomas activos \/ endosomas tard\u00edos, lo que hace que el contenido enzim\u00e1tico de los autofagolisosomas sea insuficiente para una degradaci\u00f3n adecuada.\u00a0<\/p>\n<p>En consecuencia, el recambio de mitocondrias disminuye progresivamente, lo que produce una disminuci\u00f3n de la s\u00edntesis de ATP y una mayor formaci\u00f3n de especies reactivas de ox\u00edgeno, lo que induce un mayor da\u00f1o mitocondrial y la formaci\u00f3n adicional de lipofuscina.\u00a0<\/p>\n<p>Con la edad avanzada, los lisosomas cargados de lipofuscina y las mitocondrias defectuosas ocupan partes cada vez m\u00e1s grandes de las c\u00e9lulas postmit\u00f3ticas de larga vida, dejando cada vez menos capacidad para la renovaci\u00f3n normal y la producci\u00f3n de ATP, resultando finalmente en la muerte celular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Terman, A. (2006).\u00a0Catabolic insufficiency and aging.\u00a0Annals of the New York Academy of Sciences, 1067(1), 27-36.\u00a0 Los procesos degradativos celulares, que incluyen la degradaci\u00f3n lisosomal (autof\u00e1gica) y proteasomal, as\u00ed como la actividad de las proteasas citos\u00f3licas y mitocondriales, proporcionan una renovaci\u00f3n continua de biomol\u00e9culas y org\u00e1nulos da\u00f1ados y obsoletos. La insuficiencia inherente de estos procesos degradativos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33883","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Insuficiencia catab\u00f3lica y envejecimiento&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33883\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;Insuficiencia catab\u00f3lica y envejecimiento&quot; -\" \/>\n<meta property=\"og:description\" content=\"Terman, A. (2006).\u00a0Catabolic insufficiency and aging.\u00a0Annals of the New York Academy of Sciences, 1067(1), 27-36.\u00a0 Los procesos degradativos celulares, que incluyen la degradaci\u00f3n lisosomal (autof\u00e1gica) y proteasomal, as\u00ed como la actividad de las proteasas citos\u00f3licas y mitocondriales, proporcionan una renovaci\u00f3n continua de biomol\u00e9culas y org\u00e1nulos da\u00f1ados y obsoletos. La insuficiencia inherente de estos procesos degradativos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33883\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-26T01:30:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-ywWK_O1TgF0\/Xd14YI845CI\/AAAAAAAAYvY\/efiEYaA7KRUWh1A76R7DUNUxwju4iPqCgCLcBGAsYHQ\/s320\/Annals_NewYork_Academic_Science2.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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