{"id":33889,"date":"2019-11-26T04:30:23","date_gmt":"2019-11-26T03:30:23","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33889"},"modified":"2019-11-26T04:30:23","modified_gmt":"2019-11-26T03:30:23","slug":"area-de-conocimiento-naturopatia-descriptiva-dano-oxidativo-y-mutacion-al-adn-mitocondrial-y-disminucion-dependiente-de-la-edad-de-la-funcion-respiratoria-mitocondrial","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33889","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abDa\u00f1o oxidativo y mutaci\u00f3n al ADN mitocondrial y disminuci\u00f3n dependiente de la edad de la funci\u00f3n respiratoria mitocondrial\u00bb"},"content":{"rendered":"

<\/a>Wei, Y. H., Lu, C. Y., Lee, H. C., Pang, C. Y., & Ma, Y. S. (1998).\u00a0Oxidative damage and mutation to mitochondrial DNA and age\u2010dependent decline of mitochondrial respiratory function<\/a>.\u00a0Annals of the New York Academy of Sciences<\/i>, 854(1), 155-170.\u00a0<\/p>\n

La respiraci\u00f3n mitocondrial y la fosforilaci\u00f3n oxidativa se desacoplan gradualmente, y las actividades de las enzimas respiratorias se disminuyen concomitantemente en diversos tejidos humanos al envejecer.\u00a0<\/p>\n

Una consecuencia inmediata de tal deterioro gradual de la funci\u00f3n respiratoria es el aumento en la producci\u00f3n de especies reactivas de ox\u00edgeno (ROS) y radicales libres en la mitocondria a trav\u00e9s del aumento de la p\u00e9rdida de electrones de la cadena de transporte de electrones. Adem\u00e1s, los niveles intracelulares de antioxidantes y las enzimas depuradoras de radicales libres se alteran gradualmente.\u00a0<\/p>\n

Estos dos factores de combinaci\u00f3n conducen a un aumento dependiente de la edad en la fracci\u00f3n de ROS y radicales libres que pueden escapar del mecanismo de defensa y causar da\u00f1o oxidativo a varias biomol\u00e9culas en las c\u00e9lulas de los tejidos.\u00a0<\/p>\n

Un creciente cuerpo de evidencia ha establecido que los niveles de ROS y el da\u00f1o oxidativo a l\u00edpidos, prote\u00ednas y \u00e1cidos nucleicos aumentan significativamente con la edad en tejidos animales y humanos. El ADN mitocondrial (ADNmt), aunque no est\u00e1 protegido por histonas o prote\u00ednas de uni\u00f3n al ADN, es susceptible al da\u00f1o oxidativo por los niveles cada vez mayores de ROS y radicales libres en la matriz mitocondrial.\u00a0<\/p>\n

En los \u00faltimos a\u00f1os, se ha encontrado que la modificaci\u00f3n oxidativa (formaci\u00f3n de 8-hidroxi-2′-desoxiguanosina) y la supresi\u00f3n a gran escala y la mutaci\u00f3n puntual del mtDNA aumentan exponencialmente con la edad en diversos tejidos humanos. Las enzimas respiratorias que contienen las subunidades proteicas defectuosas codificadas por mtDNA mutante exhiben inevitablemente una funci\u00f3n respiratoria deteriorada y de ese modo aumentan la fuga de electrones y la producci\u00f3n de ROS, que a su vez eleva el estr\u00e9s oxidativo y el da\u00f1o oxidativo de las mitocondrias.\u00a0<\/p>\n

Este c\u00edrculo vicioso opera en diferentes c\u00e9lulas de tejidos a diferentes velocidades y por lo tanto conduce a la acumulaci\u00f3n diferencial de la mutaci\u00f3n y el da\u00f1o oxidativo del ADN mitocondrial en el envejecimiento humano. Esto tambi\u00e9n puede jugar un papel en la patog\u00e9nesis de las enfermedades degenerativas y la progresi\u00f3n dependiente de la edad del curso cl\u00ednico de las enfermedades mitocondriales.<\/p>\n","protected":false},"excerpt":{"rendered":"

Wei, Y. H., Lu, C. Y., Lee, H. C., Pang, C. Y., & Ma, Y. S. (1998).\u00a0Oxidative damage and mutation to mitochondrial DNA and age\u2010dependent decline of mitochondrial respiratory function.\u00a0Annals of the New York Academy of Sciences, 854(1), 155-170.\u00a0 La respiraci\u00f3n mitocondrial y la fosforilaci\u00f3n oxidativa se desacoplan gradualmente, y las actividades de las enzimas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33889","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Da\u00f1o oxidativo y mutaci\u00f3n al ADN mitocondrial y disminuci\u00f3n dependiente de la edad de la funci\u00f3n respiratoria mitocondrial" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33889\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: "Da\u00f1o oxidativo y mutaci\u00f3n al ADN mitocondrial y disminuci\u00f3n dependiente de la edad de la funci\u00f3n respiratoria mitocondrial" -\" \/>\n<meta property=\"og:description\" content=\"Wei, Y. H., Lu, C. Y., Lee, H. C., Pang, C. Y., & Ma, Y. S. (1998).\u00a0Oxidative damage and mutation to mitochondrial DNA and age\u2010dependent decline of mitochondrial respiratory function.\u00a0Annals of the New York Academy of Sciences, 854(1), 155-170.\u00a0 La respiraci\u00f3n mitocondrial y la fosforilaci\u00f3n oxidativa se desacoplan gradualmente, y las actividades de las enzimas […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33889\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-26T03:30:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-OJysuRGGPWo\/Xd16t9A0GAI\/AAAAAAAAYvo\/BEsY8c4HyKMn1JklVkXNQWte0yL-04cCgCLcBGAsYHQ\/s320\/Annals_NewYork_Academic_Science.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de 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