{"id":33895,"date":"2019-11-26T06:30:55","date_gmt":"2019-11-26T05:30:55","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=33895"},"modified":"2019-11-26T06:30:55","modified_gmt":"2019-11-26T05:30:55","slug":"area-de-conocimiento-naturopatia-descriptiva-el-supresor-tumoral-pten-regula-positivamente-la-macroautofagia-al-inhibir-la-via-de-la-fosfatidilinositol-3-quinasa-proteina-quinasa-b","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=33895","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: \u00abEl supresor tumoral PTEN regula positivamente la macroautofagia al inhibir la v\u00eda de la fosfatidilinositol 3-quinasa \/ prote\u00edna quinasa B.\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-8jFdcbsjsFY\/Xd18zcJ-UaI\/AAAAAAAAYv4\/0wYFArjXZRE4pyLMitncGfy42zF-siS2QCLcBGAsYHQ\/s1600\/Journal_Biological%2BChemistry.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-8jFdcbsjsFY\/Xd18zcJ-UaI\/AAAAAAAAYv4\/0wYFArjXZRE4pyLMitncGfy42zF-siS2QCLcBGAsYHQ\/s1600\/Journal_Biological%2BChemistry.gif\" border=\"0\" data-original-width=\"200\" data-original-height=\"259\" \/><\/a>Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., &amp; Ogier-Denis, E. (2001).\u00a0<a href=\"http:\/\/www.jbc.org\/content\/276\/38\/35243.full.pdf\">The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase\/protein kinase B pathway<\/a>.\u00a0<i>Journal of Biological Chemistry<\/i>, 276(38), 35243-35246.\u00a0<\/p>\n<p>El supresor de tumores PTEN es una prote\u00edna doble y fosfoinos\u00edtido fosfatasa que controla negativamente la v\u00eda de se\u00f1alizaci\u00f3n del fosfatidilinositol (PI) 3-quinasa \/ prote\u00edna quinasa B (Akt \/ PKB). Se ha demostrado que la interleuquina-13 a trav\u00e9s de la activaci\u00f3n de la PI 3-cinasa de clase I inhibe la ruta macroautof\u00e1gica en las c\u00e9lulas HT-29 de c\u00e1ncer de colon humano.\u00a0<\/p>\n<p>Aqu\u00ed demostramos que el PTEN de tipo salvaje se expresa en esta l\u00ednea celular. Su sobreexpresi\u00f3n dirigida por un promotor inducible contrarresta la regulaci\u00f3n a la baja de interleucina 13 de macroautofagia.\u00a0<\/p>\n<p>Este efecto fue dependiente de la actividad fosfoinositida fosfatasa de PTEN como se determina usando el mutante G129E, que tiene solo actividad de prote\u00edna fosfatasa. El papel de Akt \/ PKB en el control de se\u00f1alizaci\u00f3n de macroautophagy dependiente de interleucina-13 se investig\u00f3 mediante la expresi\u00f3n de una forma constitutivamente activa de la quinasa ((Myr) PKB).\u00a0<\/p>\n<p>Bajo estas condiciones, se observ\u00f3 una inhibici\u00f3n dram\u00e1tica de la macroautofagia. Por el contrario, se observ\u00f3 una alta tasa de autofagia en c\u00e9lulas que expresan una forma dominante negativa de PKB. Estos datos demuestran que el control de se\u00f1alizaci\u00f3n de la macroautofagia se solapa con la bien conocida ruta de supervivencia PI3-quinasa \/ PKB y que la p\u00e9rdida de la funci\u00f3n PTEN en las c\u00e9lulas cancerosas inhibe una ruta catab\u00f3lica principal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., &amp; Ogier-Denis, E. (2001).\u00a0The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase\/protein kinase B pathway.\u00a0Journal of Biological Chemistry, 276(38), 35243-35246.\u00a0 El supresor de tumores PTEN es una prote\u00edna doble y fosfoinos\u00edtido fosfatasa que controla negativamente la v\u00eda de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-33895","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El supresor tumoral PTEN regula positivamente la macroautofagia al inhibir la v\u00eda de la fosfatidilinositol 3-quinasa \/ prote\u00edna quinasa B.&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=33895\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva: &quot;El supresor tumoral PTEN regula positivamente la macroautofagia al inhibir la v\u00eda de la fosfatidilinositol 3-quinasa \/ prote\u00edna quinasa B.&quot; -\" \/>\n<meta property=\"og:description\" content=\"Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. 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(2001).\u00a0The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase\/protein kinase B pathway.\u00a0Journal of Biological Chemistry, 276(38), 35243-35246.\u00a0 El supresor de tumores PTEN es una prote\u00edna doble y fosfoinos\u00edtido fosfatasa que controla negativamente la v\u00eda de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=33895\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-26T05:30:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-8jFdcbsjsFY\/Xd18zcJ-UaI\/AAAAAAAAYv4\/0wYFArjXZRE4pyLMitncGfy42zF-siS2QCLcBGAsYHQ\/s1600\/Journal_Biological%2BChemistry.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" 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