{"id":34484,"date":"2019-12-12T03:30:33","date_gmt":"2019-12-12T02:30:33","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34484"},"modified":"2019-12-12T03:30:33","modified_gmt":"2019-12-12T02:30:33","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-las-flavonas-y-los-flavonoles-dieteticos-son-inhibidores-de-la-poli-adp-ribosa-polimerasa-1-en-las-celulas-epiteliales-pulmon","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34484","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLas flavonas y los flavonoles diet\u00e9ticos son inhibidores de la poli (ADP-ribosa) polimerasa-1 en las c\u00e9lulas epiteliales pulmonares\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-7numYb1XJQA\/Xe5BH7OMORI\/AAAAAAAAZGg\/d608sRmMJnAnnG0_VIg1AG_mdFoMlia1wCLcBGAsYHQ\/s1600\/Journal_Nutrition5.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-7numYb1XJQA\/Xe5BH7OMORI\/AAAAAAAAZGg\/d608sRmMJnAnnG0_VIg1AG_mdFoMlia1wCLcBGAsYHQ\/s320\/Journal_Nutrition5.png\" width=\"238\" height=\"320\" border=\"0\" data-original-width=\"520\" data-original-height=\"697\" \/><\/a>Geraets, L., Moonen, H. J., Brauers, K., Wouters, E. F., Bast, A., &amp; Hageman, G. J. (2007).<a href=\"https:\/\/academic.oup.com\/jn\/article\/137\/10\/2190\/4664443\">\u00a0Dietary flavones and flavonoles are inhibitors of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells<\/a>.\u00a0<i>The Journal of nutrition<\/i>, 137(10), 2190-2195.<\/p>\n<p>Se ha demostrado que la enzima nuclear poli (ADP-ribosa) polimerasa-1 (PARP-1), que inicialmente se sab\u00eda que estaba altamente activada por roturas de la cadena de ADN inducida por estr\u00e9s oxidativo, est\u00e1 involucrada en la fisiopatolog\u00eda de las enfermedades inflamatorias agudas y cr\u00f3nicas.\u00a0<\/p>\n<p>La deficiencia de PARP-1 en ratones condujo al descubrimiento de su funci\u00f3n de coactivaci\u00f3n en la expresi\u00f3n g\u00e9nica mediada por el factor nuclear kappa B y, adem\u00e1s, se demostr\u00f3 que la inhibici\u00f3n farmac\u00e9utica de PARP-1 reduce la producci\u00f3n de mediadores inflamatorios.\u00a0<\/p>\n<p>En este estudio, se investig\u00f3 el efecto inhibidor de PARP-1 in vitro de varios flavonoides. Los flavonoides miricetina, tricetina, gossypetin, delphinidin, quercetin y fisetin fueron identificados como inhibidores significativos de la enzima purificada. Evaluaci\u00f3n adicional de estos compuestos en N- metil- NLas c\u00e9lulas epiteliales pulmonares humanas tratadas con \u2032 -nitro- N -nitrosoguanidina mostraron que la quercetina, fisetina y tricetina redujeron la formaci\u00f3n de los pol\u00edmeros de poli (ADP-ribosa), as\u00ed como la disminuci\u00f3n de los niveles de NAD +.\u00a0<\/p>\n<p>Finalmente, la producci\u00f3n de IL-8 de c\u00e9lulas epiteliales pulmonares humanas estimuladas con LPS podr\u00eda reducirse significativamente por estos flavonoides.\u00a0<\/p>\n<p>Los resultados de este estudio indican que los flavonoides espec\u00edficos tienen actividad inhibidora de PARP-1 adem\u00e1s de los efectos antioxidantes descritos anteriormente. Inhibici\u00f3n y preservaci\u00f3n de PARP-1 de NAD + celular y la producci\u00f3n de energ\u00eda podr\u00eda desempe\u00f1ar un papel en la actividad antiinflamatoria de estos flavonoides espec\u00edficos. Adem\u00e1s, estos resultados indican mecanismos adicionales por los cuales los flavonoides pueden ejercer actividad antiinflamatoria. Adem\u00e1s, estos resultados indican posibilidades de usar flavonoides derivados de alimentos en el tratamiento de enfermedades inflamatorias cr\u00f3nicas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Geraets, L., Moonen, H. J., Brauers, K., Wouters, E. F., Bast, A., &amp; Hageman, G. J. (2007).\u00a0Dietary flavones and flavonoles are inhibitors of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells.\u00a0The Journal of nutrition, 137(10), 2190-2195. Se ha demostrado que la enzima nuclear poli (ADP-ribosa) polimerasa-1 (PARP-1), que inicialmente se sab\u00eda que estaba altamente activada por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34484","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Las flavonas y los flavonoles diet\u00e9ticos son inhibidores de la poli (ADP-ribosa) polimerasa-1 en las c\u00e9lulas epiteliales pulmonares&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34484\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Las flavonas y los flavonoles diet\u00e9ticos son inhibidores de la poli (ADP-ribosa) polimerasa-1 en las c\u00e9lulas epiteliales pulmonares&quot; -\" \/>\n<meta property=\"og:description\" content=\"Geraets, L., Moonen, H. J., Brauers, K., Wouters, E. F., Bast, A., &amp; Hageman, G. J. (2007).\u00a0Dietary flavones and flavonoles are inhibitors of poly (ADP-ribose) polymerase-1 in pulmonary epithelial cells.\u00a0The Journal of nutrition, 137(10), 2190-2195. Se ha demostrado que la enzima nuclear poli (ADP-ribosa) polimerasa-1 (PARP-1), que inicialmente se sab\u00eda que estaba altamente activada por [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34484\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-12T02:30:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-7numYb1XJQA\/Xe5BH7OMORI\/AAAAAAAAZGg\/d608sRmMJnAnnG0_VIg1AG_mdFoMlia1wCLcBGAsYHQ\/s320\/Journal_Nutrition5.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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