{"id":34578,"date":"2019-12-13T01:30:34","date_gmt":"2019-12-13T00:30:34","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34578"},"modified":"2019-12-13T01:30:34","modified_gmt":"2019-12-13T00:30:34","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-es-un-potente-agente-de-hipometilacion-del-adn","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34578","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina es un potente agente de hipometilaci\u00f3n del ADN\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-O-BlDNTSWFI\/XfO5jnOIP6I\/AAAAAAAAZJc\/KpNO0SlNblQaSmyLfEOGDbdpqaDZ0a5mwCLcBGAsYHQ\/s1600\/Biorganica_Micinal_Chemystre.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-O-BlDNTSWFI\/XfO5jnOIP6I\/AAAAAAAAZJc\/KpNO0SlNblQaSmyLfEOGDbdpqaDZ0a5mwCLcBGAsYHQ\/s320\/Biorganica_Micinal_Chemystre.jpg\" width=\"233\" height=\"320\" border=\"0\" data-original-width=\"328\" data-original-height=\"450\" \/><\/a>Liu, Z., Xie, Z., Jones, W., Pavlovicz, R. E., Liu, S., Yu, J., &#8230; &amp; Li, C. (2009).\u00a0<a href=\"http:\/\/www.tahomaclinic.com\/Private\/Articles2\/BreastCA\/Liu%202009%20-%20Curcumin%20is%20a%20potent%20DNA%20hypomethylation%20agent.pdf\">Curcumin is a potent DNA hypomethylation agent<\/a>.\u00a0<i>Bioorganic &amp; medicinal chemistry letters<\/i>, 19(3), 706-709.<\/p>\n<p>El acoplamiento molecular de la interacci\u00f3n de la curcumina y DNMT1 sugiri\u00f3 que la curcumina bloquea covalentemente el tiolato catal\u00edtico de C1226 de DNMT1 para ejercer su efecto inhibidor. E<\/p>\n<p>Esto se valid\u00f3 mostrando que la curcumina inhibe la actividad de M. SssI con un IC (50) de 30 nM, pero no actividad inhibitoria de la hexahidrocurcumina hasta 100 microM.\u00a0<\/p>\n<p>Adem\u00e1s, la curcumina puede inducir la hipometilaci\u00f3n global del ADN en una l\u00ednea celular de leucemia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu, Z., Xie, Z., Jones, W., Pavlovicz, R. E., Liu, S., Yu, J., &#8230; &amp; Li, C. (2009).\u00a0Curcumin is a potent DNA hypomethylation agent.\u00a0Bioorganic &amp; medicinal chemistry letters, 19(3), 706-709. El acoplamiento molecular de la interacci\u00f3n de la curcumina y DNMT1 sugiri\u00f3 que la curcumina bloquea covalentemente el tiolato catal\u00edtico de C1226 de DNMT1 para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34578","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina es un potente agente de hipometilaci\u00f3n del ADN&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina es un potente agente de hipometilaci\u00f3n del ADN&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liu, Z., Xie, Z., Jones, W., Pavlovicz, R. E., Liu, S., Yu, J., &#8230; &amp; Li, C. (2009).\u00a0Curcumin is a potent DNA hypomethylation agent.\u00a0Bioorganic &amp; medicinal chemistry letters, 19(3), 706-709. El acoplamiento molecular de la interacci\u00f3n de la curcumina y DNMT1 sugiri\u00f3 que la curcumina bloquea covalentemente el tiolato catal\u00edtico de C1226 de DNMT1 para [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-13T00:30:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-O-BlDNTSWFI\/XfO5jnOIP6I\/AAAAAAAAZJc\/KpNO0SlNblQaSmyLfEOGDbdpqaDZ0a5mwCLcBGAsYHQ\/s320\/Biorganica_Micinal_Chemystre.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina es un potente agente de hipometilaci\u00f3n del ADN\u00bb\",\"datePublished\":\"2019-12-13T00:30:34+00:00\",\"dateModified\":\"2019-12-13T00:30:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\"},\"wordCount\":126,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=34578#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La curcumina es un potente agente de hipometilaci\u00f3n del ADN\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2019-12-13T00:30:34+00:00\",\"dateModified\":\"2019-12-13T00:30:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=34578\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=34578#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina es un potente agente de hipometilaci\u00f3n del ADN\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina es un potente agente de hipometilaci\u00f3n del ADN\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=34578","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina es un potente agente de hipometilaci\u00f3n del ADN\" -","og_description":"Liu, Z., Xie, Z., Jones, W., Pavlovicz, R. E., Liu, S., Yu, J., &#8230; &amp; Li, C. (2009).\u00a0Curcumin is a potent DNA hypomethylation agent.\u00a0Bioorganic &amp; medicinal chemistry letters, 19(3), 706-709. El acoplamiento molecular de la interacci\u00f3n de la curcumina y DNMT1 sugiri\u00f3 que la curcumina bloquea covalentemente el tiolato catal\u00edtico de C1226 de DNMT1 para [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=34578","article_published_time":"2019-12-13T00:30:34+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-O-BlDNTSWFI\/XfO5jnOIP6I\/AAAAAAAAZJc\/KpNO0SlNblQaSmyLfEOGDbdpqaDZ0a5mwCLcBGAsYHQ\/s320\/Biorganica_Micinal_Chemystre.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina es un potente agente de hipometilaci\u00f3n del ADN\u00bb","datePublished":"2019-12-13T00:30:34+00:00","dateModified":"2019-12-13T00:30:34+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578"},"wordCount":126,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=34578#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578","url":"https:\/\/rina.naturopatiadigital.eu\/?p=34578","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina es un potente agente de hipometilaci\u00f3n del ADN\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2019-12-13T00:30:34+00:00","dateModified":"2019-12-13T00:30:34+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=34578"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=34578#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina es un potente agente de hipometilaci\u00f3n del ADN\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/34578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34578"}],"version-history":[{"count":0,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/34578\/revisions"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}