{"id":34580,"date":"2019-12-13T02:30:10","date_gmt":"2019-12-13T01:30:10","guid":{"rendered":"https:\/\/naturopatiadigital.eu\/?p=34580"},"modified":"2019-12-13T02:30:10","modified_gmt":"2019-12-13T01:30:10","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-provoca-la-hipometilacion-del-promotor-y-una-mayor-expresion-del-gen-fancf-en-la-linea-celular-siha","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=34580","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina provoca la hipometilaci\u00f3n del promotor y una mayor expresi\u00f3n del gen FANCF en la l\u00ednea celular SiHa\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-5s2InFKiC1c\/XfO63SvHELI\/AAAAAAAAZJk\/qqUsaBBMgKQwKrCp6wROxnxMVRSDs0PjgCLcBGAsYHQ\/s1600\/Molecular_Celular_Biochemystre.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-5s2InFKiC1c\/XfO63SvHELI\/AAAAAAAAZJk\/qqUsaBBMgKQwKrCp6wROxnxMVRSDs0PjgCLcBGAsYHQ\/s1600\/Molecular_Celular_Biochemystre.jpg\" border=\"0\" data-original-width=\"192\" data-original-height=\"262\" \/><\/a>Parashar, G., Parashar, N. C., &amp; Capalash, N. (2012).\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11010-012-1240-z\">Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line<\/a>.\u00a0<i>Molecular and cellular biochemistry<\/i>, 365(1-2), 29-35.<\/p>\n<p>La curcumina y el resveratrol se evaluaron por su potencial para causar la reversi\u00f3n de la hipermetilaci\u00f3n del promotor y la expresi\u00f3n g\u00e9nica asociada de FANCF en la l\u00ednea celular SiHa.\u00a0<\/p>\n<p>La PCR espec\u00edfica de metilaci\u00f3n junto con la secuenciaci\u00f3n de bisulfito revel\u00f3 la desmetilaci\u00f3n de 12 sitios CpG de 15 sitios CpG que abarcan la regi\u00f3n? 280 a? 432 del promotor FANCF despu\u00e9s del tratamiento con curcumina y una regulaci\u00f3n cinco veces mayor de la expresi\u00f3n del gen FANCF como se muestra por qRT-PCR.\u00a0<\/p>\n<p>El ensayo de metilaci\u00f3n in vitro tambi\u00e9n mostr\u00f3 que M.SssI, un an\u00e1logo de DNMT1, se inhibi\u00f3 efectivamente a una concentraci\u00f3n de curcumina de 50 lM.\u00a0<\/p>\n<p>No se encontr\u00f3 que el resveratrol sea efectivo para causar la reversi\u00f3n de la hipermetilaci\u00f3n del promotor del gen FANCF cuando se usa a 20 lM durante 4 d\u00edas en la l\u00ednea celular SiHa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Parashar, G., Parashar, N. C., &amp; Capalash, N. (2012).\u00a0Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line.\u00a0Molecular and cellular biochemistry, 365(1-2), 29-35. La curcumina y el resveratrol se evaluaron por su potencial para causar la reversi\u00f3n de la hipermetilaci\u00f3n del promotor y la expresi\u00f3n g\u00e9nica asociada de FANCF en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-34580","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina provoca la hipometilaci\u00f3n del promotor y una mayor expresi\u00f3n del gen FANCF en la l\u00ednea celular SiHa&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=34580\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina provoca la hipometilaci\u00f3n del promotor y una mayor expresi\u00f3n del gen FANCF en la l\u00ednea celular SiHa&quot; -\" \/>\n<meta property=\"og:description\" content=\"Parashar, G., Parashar, N. 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La curcumina y el resveratrol se evaluaron por su potencial para causar la reversi\u00f3n de la hipermetilaci\u00f3n del promotor y la expresi\u00f3n g\u00e9nica asociada de FANCF en la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=34580\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-13T01:30:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-5s2InFKiC1c\/XfO63SvHELI\/AAAAAAAAZJk\/qqUsaBBMgKQwKrCp6wROxnxMVRSDs0PjgCLcBGAsYHQ\/s1600\/Molecular_Celular_Biochemystre.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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